CD302_BOVIN
ID CD302_BOVIN Reviewed; 232 AA.
AC A8WH74; A8YXZ1; F1MF05;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=CD302 antigen {ECO:0000250|UniProtKB:Q8IX05};
DE AltName: Full=Type I transmembrane C-type lectin receptor DCL-1 {ECO:0000303|PubMed:17947679};
DE Flags: Precursor;
GN Name=CD302 {ECO:0000312|EMBL:AAI05309.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1] {ECO:0000312|Ensembl:ENSBTAP00000050116}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000312|Ensembl:ENSBTAP00000050116};
RX PubMed=19390049; DOI=10.1126/science.1169588;
RG The bovine genome sequencing and analysis consortium;
RT "The genome sequence of taurine cattle: a window to ruminant biology and
RT evolution.";
RL Science 324:522-528(2009).
RN [2] {ECO:0000312|EMBL:AAI05309.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus {ECO:0000312|EMBL:AAI05309.1};
RC TISSUE=Ileum {ECO:0000312|EMBL:AAI05309.1};
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA06088.1}
RP IDENTIFICATION.
RX PubMed=17947679; DOI=10.4049/jimmunol.179.9.6052;
RA Kato M., Khan S., d'Aniello E., McDonald K.J., Hart D.N.;
RT "The novel endocytic and phagocytic C-Type lectin receptor DCL-1/CD302 on
RT macrophages is colocalized with F-actin, suggesting a role in cell adhesion
RT and migration.";
RL J. Immunol. 179:6052-6063(2007).
CC -!- FUNCTION: Potential multifunctional C-type lectin receptor that may
CC play roles in endocytosis and phagocytosis as well as in cell adhesion
CC and migration. {ECO:0000250|UniProtKB:Q8IX05}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC membrane protein {ECO:0000255}. Cell projection, filopodium
CC {ECO:0000250|UniProtKB:Q8IX05, ECO:0000255}. Cytoplasm, cell cortex
CC {ECO:0000250|UniProtKB:Q8IX05, ECO:0000255}. Cell projection,
CC microvillus {ECO:0000250|UniProtKB:Q8IX05, ECO:0000255}.
CC Note=Colocalizes with F-actin in filopodia, cellular cortex and
CC microvilli of the apical cell surface. {ECO:0000250|UniProtKB:Q8IX05,
CC ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI05309.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AAFC03027417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC105308; AAI05309.1; ALT_FRAME; mRNA.
DR EMBL; BK006292; DAA06088.1; -; mRNA.
DR RefSeq; NP_001103661.1; NM_001110191.1.
DR AlphaFoldDB; A8WH74; -.
DR SMR; A8WH74; -.
DR STRING; 9913.ENSBTAP00000050116; -.
DR PaxDb; A8WH74; -.
DR Ensembl; ENSBTAT00000056635; ENSBTAP00000050116; ENSBTAG00000038195.
DR GeneID; 100126272; -.
DR KEGG; bta:100126272; -.
DR CTD; 9936; -.
DR VEuPathDB; HostDB:ENSBTAG00000038195; -.
DR VGNC; VGNC:55333; CD302.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT01050000244928; -.
DR HOGENOM; CLU_088281_0_0_1; -.
DR InParanoid; A8WH74; -.
DR OMA; RWENVSC; -.
DR OrthoDB; 1071894at2759; -.
DR Proteomes; UP000009136; Chromosome 2.
DR Bgee; ENSBTAG00000038195; Expressed in liver and 106 other tissues.
DR ExpressionAtlas; A8WH74; baseline and differential.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0006909; P:phagocytosis; IEA:Ensembl.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cytoplasm; Disulfide bond; Glycoprotein; Lectin; Membrane;
KW Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..232
FT /note="CD302 antigen"
FT /evidence="ECO:0000255"
FT /id="PRO_0000413655"
FT TOPO_DOM 23..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..152
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 128..143
FT /evidence="ECO:0000250|UniProtKB:Q5KU26,
FT ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 232 AA; 25972 MW; 4F4B39E128D94B7D CRC64;
MPRAAPPALL LPLLGLAAAA AADCPSSTWV QFQDSCYIFL QEAIKVESIE DVRNQCTNHG
ADMISIHNEE ENAFILDTLK KQWKDPADIL LGMFFDTDDA SFKWFDNSNM TFNKWSDQED
DEELVDTCAF LHTKTGDWKK GNCEVSSVEG TLCKAAIPYE KKYLSDNRIL ISALVIASTV
ILTVLGAVVW FLYKRSLDSG FTTVFSAAHQ SPYNDDCVLV VAEENEYDIQ FN
