CD302_MOUSE
ID CD302_MOUSE Reviewed; 228 AA.
AC Q9DCG2; A2AW84; A2AW85; Q78KD8; Q9D0X7;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=CD302 antigen;
DE AltName: Full=C-type lectin domain family 13 member A;
DE AltName: Full=Type I transmembrane C-type lectin receptor DCL-1;
DE AltName: CD_antigen=CD302;
DE Flags: Precursor;
GN Name=Cd302; Synonyms=Clec13a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-228 (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Potential multifunctional C-type lectin receptor that may
CC play roles in endocytosis and phagocytosis as well as in cell adhesion
CC and migration. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}. Cell projection, filopodium
CC {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection,
CC microvillus {ECO:0000250}. Note=Colocalizes with F-actin in filopodia,
CC cellular cortex and microvilli of the apical cell surface.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9DCG2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DCG2-2; Sequence=VSP_020910;
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DR EMBL; AK002812; BAB22377.2; -; mRNA.
DR EMBL; AK004267; BAB23242.2; -; mRNA.
DR EMBL; AL935326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466519; EDL26959.1; -; Genomic_DNA.
DR EMBL; CH466519; EDL26960.1; -; Genomic_DNA.
DR EMBL; BC005501; AAH05501.1; -; mRNA.
DR CCDS; CCDS16058.1; -. [Q9DCG2-2]
DR CCDS; CCDS71058.1; -. [Q9DCG2-1]
DR RefSeq; NP_001277589.1; NM_001290660.1. [Q9DCG2-1]
DR RefSeq; NP_079698.2; NM_025422.4. [Q9DCG2-2]
DR AlphaFoldDB; Q9DCG2; -.
DR SMR; Q9DCG2; -.
DR STRING; 10090.ENSMUSP00000028356; -.
DR GlyGen; Q9DCG2; 1 site.
DR PhosphoSitePlus; Q9DCG2; -.
DR SwissPalm; Q9DCG2; -.
DR jPOST; Q9DCG2; -.
DR MaxQB; Q9DCG2; -.
DR PaxDb; Q9DCG2; -.
DR PeptideAtlas; Q9DCG2; -.
DR PRIDE; Q9DCG2; -.
DR ProteomicsDB; 279963; -. [Q9DCG2-1]
DR ProteomicsDB; 279964; -. [Q9DCG2-2]
DR Antibodypedia; 47602; 245 antibodies from 28 providers.
DR DNASU; 66205; -.
DR Ensembl; ENSMUST00000028356; ENSMUSP00000028356; ENSMUSG00000060703. [Q9DCG2-2]
DR Ensembl; ENSMUST00000074606; ENSMUSP00000074188; ENSMUSG00000060703. [Q9DCG2-1]
DR GeneID; 66205; -.
DR KEGG; mmu:66205; -.
DR UCSC; uc008jub.2; mouse. [Q9DCG2-2]
DR UCSC; uc008juc.2; mouse. [Q9DCG2-1]
DR CTD; 9936; -.
DR MGI; MGI:1913455; Cd302.
DR VEuPathDB; HostDB:ENSMUSG00000060703; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT01050000244928; -.
DR HOGENOM; CLU_088281_0_0_1; -.
DR InParanoid; Q9DCG2; -.
DR OMA; RWENVSC; -.
DR OrthoDB; 1071894at2759; -.
DR PhylomeDB; Q9DCG2; -.
DR BioGRID-ORCS; 66205; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Cd302; mouse.
DR PRO; PR:Q9DCG2; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9DCG2; protein.
DR Bgee; ENSMUSG00000060703; Expressed in left lobe of liver and 246 other tissues.
DR Genevisible; Q9DCG2; MM.
DR GO; GO:0005938; C:cell cortex; ISO:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0030175; C:filopodium; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005902; C:microvillus; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0006909; P:phagocytosis; ISO:MGI.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell projection; Cytoplasm; Disulfide bond;
KW Glycoprotein; Lectin; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..228
FT /note="CD302 antigen"
FT /id="PRO_0000252333"
FT TOPO_DOM 21..165
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 187..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 30..149
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT CARBOHYD 107
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 125..140
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT VAR_SEQ 154..163
FT /note="IPYDKKYLSD -> N (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_020910"
SQ SEQUENCE 228 AA; 25423 MW; 7482F9DB7DC9FD10 CRC64;
MPHAALSSLV LLSLATAIVA DCPSSTWVQF QGSCYAFLQV TINVENIEDV RKQCTDHGAD
MVSIHNEEEN AFILDTLQKR WKGPDDLLLG MFYDTDDATF KWYDHSNMTF DKWADQDGED
LVDTCGFLYT KTGEWRKGDC EISSVEGTLC KAAIPYDKKY LSDNHILIST LVIASTVTLA
VLGAIIWFLY RRNARSGFTS FSPAPLSPYS DGCALVVAEE DEYAVQLD