ID   CD37L_XENTR             Reviewed;         285 AA.
AC   Q28HY7;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Hsp90 co-chaperone Cdc37-like 1;
GN   Name=cdc37l1; ORFNames=TEgg077n10.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Co-chaperone that binds to numerous proteins and promotes
CC       their interaction with Hsp70 and Hsp90. {ECO:0000250}.
CC   -!- SUBUNIT: Forms complexes with Hsp70 and Hsp90. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC37 family. {ECO:0000305}.
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DR   EMBL; CR760680; CAJ82202.1; -; mRNA.
DR   RefSeq; NP_001037905.1; NM_001044440.1.
DR   AlphaFoldDB; Q28HY7; -.
DR   SMR; Q28HY7; -.
DR   PaxDb; Q28HY7; -.
DR   GeneID; 733511; -.
DR   KEGG; xtr:733511; -.
DR   CTD; 55664; -.
DR   Xenbase; XB-GENE-984706; cdc37l1.
DR   eggNOG; KOG2260; Eukaryota.
DR   InParanoid; Q28HY7; -.
DR   OrthoDB; 786744at2759; -.
DR   Reactome; R-XTR-114608; Platelet degranulation.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0051087; F:chaperone binding; IBA:GO_Central.
DR   GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   GO; GO:0050821; P:protein stabilization; IBA:GO_Central.
DR   Gene3D; 1.20.58.610; -; 1.
DR   InterPro; IPR004918; Cdc37.
DR   InterPro; IPR013874; Cdc37_Hsp90-bd.
DR   InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR   PANTHER; PTHR12800; PTHR12800; 1.
DR   Pfam; PF08565; CDC37_M; 1.
DR   SMART; SM01070; CDC37_M; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..285
FT                   /note="Hsp90 co-chaperone Cdc37-like 1"
FT                   /id="PRO_0000318526"
FT   REGION          34..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          35..73
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        34..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   285 AA;  32880 MW;  D72A0B3CFC261AA5 CRC64;
     MDFSHSQQNE CARSSVACKW SLAEAQQKLN SLALHNSESM DQEQAMAQAE LSELQRSEEE
     WRRKEAALSQ GENWGLPTTD GLNQDVFNKS FINQVKKSID GEDQSISFIQ KYEAKIRHFG
     MLSRWNDSQH FLSEYPDLVS EETAKYLLLW CSHLESEQKT ALMEQVAHQA VVMQFIIEMA
     KSCNMDPRGC FRLFFQKAKE EKEGYFEAFK SELEILKSKV RQHAECQRYE AAILRKPAFP
     PDLGHMGTQQ CHQKDVLQSH PNAAVCHLNP MEHAEDEDLK MMDTL