ID   CD37_BOVIN              Reviewed;         280 AA.
AC   Q2KHY8;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Leukocyte antigen CD37;
DE   AltName: CD_antigen=CD37;
GN   Name=CD37;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with SCIMP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; BC112834; AAI12835.1; -; mRNA.
DR   RefSeq; NP_001039476.1; NM_001046011.2.
DR   AlphaFoldDB; Q2KHY8; -.
DR   SMR; Q2KHY8; -.
DR   STRING; 9913.ENSBTAP00000015173; -.
DR   PaxDb; Q2KHY8; -.
DR   PRIDE; Q2KHY8; -.
DR   GeneID; 508751; -.
DR   KEGG; bta:508751; -.
DR   CTD; 951; -.
DR   eggNOG; KOG3882; Eukaryota.
DR   HOGENOM; CLU_055524_2_0_1; -.
DR   InParanoid; Q2KHY8; -.
DR   OrthoDB; 1207549at2759; -.
DR   TreeFam; TF352892; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..280
FT                   /note="Leukocyte antigen CD37"
FT                   /id="PRO_0000284959"
FT   TOPO_DOM        1..17
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..59
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..85
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        112..240
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        266..280
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        170
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        183
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        188
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        232
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   280 AA;  31764 MW;  A52651ED1ADB9773 CRC64;
     MSAHDGCLSL VKYLLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLS FMPLQIWSKV
     LAVSGILTMG LALLGCVGAL KEFRCLLGLY FGTLLLLFAT QITLGILIST QRVQLKKKVK
     DVVQKTIQNY RTHPEETAAE ESWDYVQFQL RCCGWESPQD WFHIPSMRRN ESEGDRVPCS
     CYNSSATNDS TIFDKISPQF SRLGSLAQPR HNVEVCSVPA NSYIYQQGCE RNLSNWLTNN
     LISIVGICLG VGLLELSFMT LSIFLCRNLD HVYDRLARYR