CD37_HUMAN
ID CD37_HUMAN Reviewed; 281 AA.
AC P11049; B4DVC1; Q3KPF9;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 2.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Leukocyte antigen CD37;
DE AltName: Full=Tetraspanin-26;
DE Short=Tspan-26;
DE AltName: CD_antigen=CD37;
GN Name=CD37; Synonyms=TSPAN26;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=2466944; DOI=10.1084/jem.169.4.1497;
RA Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.;
RT "The primary structure of the human leukocyte antigen CD37, a species
RT homologue of the rat MRC OX-44 antigen.";
RL J. Exp. Med. 169:1497-1502(1989).
RN [2]
RP ERRATUM OF PUBMED:2466944, AND SEQUENCE REVISION.
RX PubMed=2388030; DOI=10.1084/jem.172.3.1007;
RA Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.;
RL J. Exp. Med. 172:1007-1007(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
RA Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
RA LaBaer J.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP INTERACTION WITH SCIMP.
RX PubMed=21930792; DOI=10.1128/mcb.05817-11;
RA Draber P., Vonkova I., Stepanek O., Hrdinka M., Kucova M., Skopcova T.,
RA Otahal P., Angelisova P., Horejsi V., Yeung M., Weiss A., Brdicka T.;
RT "SCIMP, a transmembrane adapter protein involved in major
RT histocompatibility complex class II signaling.";
RL Mol. Cell. Biol. 31:4550-4562(2011).
CC -!- SUBUNIT: Interacts with SCIMP. {ECO:0000269|PubMed:21930792}.
CC -!- INTERACTION:
CC P11049; P19397: CD53; NbExp=3; IntAct=EBI-6139068, EBI-6657396;
CC P11049; P54849: EMP1; NbExp=3; IntAct=EBI-6139068, EBI-4319440;
CC P11049; P08034: GJB1; NbExp=3; IntAct=EBI-6139068, EBI-17565645;
CC P11049; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-6139068, EBI-2820517;
CC P11049; Q96PB8: LRRC3B; NbExp=3; IntAct=EBI-6139068, EBI-17775622;
CC P11049; P07948: LYN; NbExp=5; IntAct=EBI-6139068, EBI-79452;
CC P11049; P29350: PTPN6; NbExp=4; IntAct=EBI-6139068, EBI-78260;
CC P11049; P43405: SYK; NbExp=3; IntAct=EBI-6139068, EBI-78302;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=P11049-1; Sequence=Displayed;
CC Name=2;
CC IsoId=P11049-2; Sequence=VSP_047228;
CC Name=3;
CC IsoId=P11049-3; Sequence=VSP_047228, VSP_047229;
CC -!- TISSUE SPECIFICITY: B-lymphocytes.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; X14046; CAA32204.1; -; mRNA.
DR EMBL; AK301016; BAG62633.1; -; mRNA.
DR EMBL; CR541877; CAG46675.1; -; mRNA.
DR EMBL; BT019851; AAV38654.1; -; mRNA.
DR EMBL; AC010524; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC011450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC106752; AAI06753.1; -; mRNA.
DR EMBL; BC110379; AAI10380.1; -; mRNA.
DR CCDS; CCDS12760.1; -. [P11049-1]
DR CCDS; CCDS46139.1; -. [P11049-2]
DR PIR; A47629; A47629.
DR RefSeq; NP_001035120.1; NM_001040031.1. [P11049-2]
DR RefSeq; NP_001765.1; NM_001774.2. [P11049-1]
DR RefSeq; XP_011525846.1; XM_011527544.2. [P11049-2]
DR RefSeq; XP_016883002.1; XM_017027513.1. [P11049-2]
DR AlphaFoldDB; P11049; -.
DR SMR; P11049; -.
DR BioGRID; 107389; 8.
DR IntAct; P11049; 14.
DR MINT; P11049; -.
DR STRING; 9606.ENSP00000325708; -.
DR ChEMBL; CHEMBL3712880; -.
DR GuidetoPHARMACOLOGY; 3010; -.
DR GlyGen; P11049; 3 sites.
DR iPTMnet; P11049; -.
DR PhosphoSitePlus; P11049; -.
DR SwissPalm; P11049; -.
DR BioMuta; CD37; -.
DR DMDM; 115983; -.
DR jPOST; P11049; -.
DR MassIVE; P11049; -.
DR MaxQB; P11049; -.
DR PaxDb; P11049; -.
DR PeptideAtlas; P11049; -.
DR PRIDE; P11049; -.
DR ProteomicsDB; 52690; -. [P11049-1]
DR ABCD; P11049; 26 sequenced antibodies.
DR Antibodypedia; 3735; 669 antibodies from 36 providers.
DR DNASU; 951; -.
DR Ensembl; ENST00000323906.9; ENSP00000325708.3; ENSG00000104894.12. [P11049-1]
DR Ensembl; ENST00000426897.6; ENSP00000413151.1; ENSG00000104894.12. [P11049-2]
DR Ensembl; ENST00000598095.5; ENSP00000470394.1; ENSG00000104894.12. [P11049-3]
DR GeneID; 951; -.
DR KEGG; hsa:951; -.
DR MANE-Select; ENST00000323906.9; ENSP00000325708.3; NM_001774.3; NP_001765.1.
DR UCSC; uc002pnd.4; human. [P11049-1]
DR CTD; 951; -.
DR DisGeNET; 951; -.
DR GeneCards; CD37; -.
DR HGNC; HGNC:1666; CD37.
DR HPA; ENSG00000104894; Tissue enhanced (bone marrow, intestine, lymphoid tissue).
DR MIM; 151523; gene.
DR neXtProt; NX_P11049; -.
DR OpenTargets; ENSG00000104894; -.
DR PharmGKB; PA26213; -.
DR VEuPathDB; HostDB:ENSG00000104894; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000161485; -.
DR HOGENOM; CLU_055524_10_1_1; -.
DR InParanoid; P11049; -.
DR OMA; LSIFMCR; -.
DR OrthoDB; 1207549at2759; -.
DR PhylomeDB; P11049; -.
DR TreeFam; TF352892; -.
DR PathwayCommons; P11049; -.
DR SignaLink; P11049; -.
DR BioGRID-ORCS; 951; 11 hits in 1078 CRISPR screens.
DR ChiTaRS; CD37; human.
DR GeneWiki; CD37; -.
DR GenomeRNAi; 951; -.
DR Pharos; P11049; Tbio.
DR PRO; PR:P11049; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P11049; protein.
DR Bgee; ENSG00000104894; Expressed in granulocyte and 117 other tissues.
DR ExpressionAtlas; P11049; baseline and differential.
DR Genevisible; P11049; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0001772; C:immunological synapse; IDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..281
FT /note="Leukocyte antigen CD37"
FT /id="PRO_0000219209"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..241
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..68
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047228"
FT VAR_SEQ 257..281
FT /note="LGFMTLSIFLCRNLDHVYNRLARYR -> VIWPRPHPRSALNP (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047229"
SQ SEQUENCE 281 AA; 31703 MW; 4342C5FB4479FDC8 CRC64;
MSAQESCLSL IKYFLFVFNL FFFVLGSLIF CFGIWILIDK TSFVSFVGLA FVPLQIWSKV
LAISGIFTMG IALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRAQLERSLR
DVVEKTIQKY GTNPEETAAE ESWDYVQFQL RCCGWHYPQD WFQVLILRGN GSEAHRVPCS
CYNLSATNDS TILDKVILPQ LSRLGHLARS RHSADICAVP AESHIYREGC AQGLQKWLHN
NLISIVGICL GVGLLELGFM TLSIFLCRNL DHVYNRLARY R
