CD37_MOUSE
ID CD37_MOUSE Reviewed; 281 AA.
AC Q61470;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Leukocyte antigen CD37;
DE AltName: CD_antigen=CD37;
GN Name=Cd37;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/Sv; TISSUE=Liver;
RX PubMed=8845018; DOI=10.1016/0161-5890(96)84612-8;
RA Tomlinson M.G., Wright M.D.;
RT "Characterisation of mouse CD37: cDNA and genomic cloning.";
RL Mol. Immunol. 33:867-872(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with SCIMP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; U18372; AAB39500.1; -; Genomic_DNA.
DR EMBL; U18367; AAB39500.1; JOINED; Genomic_DNA.
DR EMBL; U18368; AAB39500.1; JOINED; Genomic_DNA.
DR EMBL; U18369; AAB39500.1; JOINED; Genomic_DNA.
DR EMBL; U18370; AAB39500.1; JOINED; Genomic_DNA.
DR EMBL; U18371; AAB39500.1; JOINED; Genomic_DNA.
DR EMBL; BC019402; AAH19402.1; -; mRNA.
DR CCDS; CCDS21237.1; -.
DR RefSeq; NP_031671.1; NM_007645.4.
DR AlphaFoldDB; Q61470; -.
DR SMR; Q61470; -.
DR STRING; 10090.ENSMUSP00000096061; -.
DR GlyGen; Q61470; 3 sites.
DR iPTMnet; Q61470; -.
DR PhosphoSitePlus; Q61470; -.
DR SwissPalm; Q61470; -.
DR EPD; Q61470; -.
DR MaxQB; Q61470; -.
DR PaxDb; Q61470; -.
DR PRIDE; Q61470; -.
DR ProteomicsDB; 283748; -.
DR ABCD; Q61470; 1 sequenced antibody.
DR Antibodypedia; 3735; 669 antibodies from 36 providers.
DR DNASU; 12493; -.
DR Ensembl; ENSMUST00000098461; ENSMUSP00000096061; ENSMUSG00000030798.
DR GeneID; 12493; -.
DR KEGG; mmu:12493; -.
DR UCSC; uc009guh.1; mouse.
DR CTD; 951; -.
DR MGI; MGI:88330; Cd37.
DR VEuPathDB; HostDB:ENSMUSG00000030798; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000161485; -.
DR HOGENOM; CLU_055524_2_0_1; -.
DR InParanoid; Q61470; -.
DR OrthoDB; 1207549at2759; -.
DR PhylomeDB; Q61470; -.
DR TreeFam; TF352892; -.
DR BioGRID-ORCS; 12493; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Cd37; mouse.
DR PRO; PR:Q61470; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q61470; protein.
DR Bgee; ENSMUSG00000030798; Expressed in granulocyte and 83 other tissues.
DR ExpressionAtlas; Q61470; baseline and differential.
DR Genevisible; Q61470; MM.
DR GO; GO:0001772; C:immunological synapse; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0042832; P:defense response to protozoan; IGI:MGI.
DR GO; GO:0030886; P:negative regulation of myeloid dendritic cell activation; IGI:MGI.
DR GO; GO:0042130; P:negative regulation of T cell proliferation; IGI:MGI.
DR GO; GO:0002639; P:positive regulation of immunoglobulin production; IMP:MGI.
DR GO; GO:0050688; P:regulation of defense response to virus; IGI:MGI.
DR GO; GO:0002920; P:regulation of humoral immune response; IMP:MGI.
DR GO; GO:0042098; P:T cell proliferation; IGI:MGI.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..281
FT /note="Leukocyte antigen CD37"
FT /id="PRO_0000219210"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..74
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..241
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 267..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 188
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 281 AA; 31852 MW; 5B0E11B3B9CCA22D CRC64;
MSAQESCLSL IKYFLFVFNL FFFVLGGLIF CFGTWILIDK TSFVSFVGLS FVPLQTWSKV
LAVSGVLTMA LALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRVRLERRVQ
ELVLRTIQSY RTNPDETAAE ESWDYAQFQL RCCGWQSPRD WNKAQMLKAN ESEEPFVPCS
CYNSTATNDS TVFDKLFFSQ LSRLGPRAKL RQTADICALP AKAHIYREGC AQSLQKWLHN
NIISIVGICL GVGLLELGFM TLSIFLCRNL DHVYDRLARY R
