ID   CD37_RAT                Reviewed;         281 AA.
AC   P31053;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 134.
DE   RecName: Full=Leukocyte antigen CD37;
DE   AltName: CD_antigen=CD37;
GN   Name=Cd37;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=PVG X DA;
RX   PubMed=2466944; DOI=10.1084/jem.169.4.1497;
RA   Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.;
RT   "The primary structure of the human leukocyte antigen CD37, a species
RT   homologue of the rat MRC OX-44 antigen.";
RL   J. Exp. Med. 169:1497-1502(1989).
RN   [2]
RP   ERRATUM OF PUBMED:2466944.
RX   PubMed=2388030; DOI=10.1084/jem.172.3.1007;
RA   Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.;
RL   J. Exp. Med. 172:1007-1007(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pituitary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Interacts with SCIMP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: B-lymphocytes.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X53517; CAA37596.1; -; mRNA.
DR   EMBL; BC059144; AAH59144.1; -; mRNA.
DR   PIR; B47629; B47629.
DR   RefSeq; NP_058820.1; NM_017124.1.
DR   AlphaFoldDB; P31053; -.
DR   SMR; P31053; -.
DR   STRING; 10116.ENSRNOP00000059092; -.
DR   GlyGen; P31053; 3 sites.
DR   PhosphoSitePlus; P31053; -.
DR   PaxDb; P31053; -.
DR   GeneID; 29185; -.
DR   KEGG; rno:29185; -.
DR   UCSC; RGD:62035; rat.
DR   CTD; 951; -.
DR   RGD; 62035; Cd37.
DR   eggNOG; KOG3882; Eukaryota.
DR   HOGENOM; CLU_055524_2_0_1; -.
DR   InParanoid; P31053; -.
DR   OrthoDB; 1207549at2759; -.
DR   PhylomeDB; P31053; -.
DR   PRO; PR:P31053; -.
DR   Proteomes; UP000002494; Unplaced.
DR   Genevisible; P31053; RN.
DR   GO; GO:0001772; C:immunological synapse; ISO:RGD.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042832; P:defense response to protozoan; ISO:RGD.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0030886; P:negative regulation of myeloid dendritic cell activation; ISO:RGD.
DR   GO; GO:0002639; P:positive regulation of immunoglobulin production; ISO:RGD.
DR   GO; GO:0050688; P:regulation of defense response to virus; ISO:RGD.
DR   GO; GO:0002920; P:regulation of humoral immune response; ISO:RGD.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..281
FT                   /note="Leukocyte antigen CD37"
FT                   /id="PRO_0000219211"
FT   TOPO_DOM        1..17
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        39..59
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..74
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        75..85
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        86..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        112..241
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        267..281
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        170
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        183
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        188
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   281 AA;  31750 MW;  A3462D23E824AA1C CRC64;
     MSAQESCLSL IKYFLFVFNL FFFVLGGLIF CFGTWILIDK TSFVSFVGLS FVPLQTWSKV
     LSVSGVLTMA LALLGCVGAL KELRCLLGLY FGMLLLLFAT QITLGILIST QRVRLERRVQ
     ELVLRTIQSY RTNPDETAAE ESWDYAQFQL RCCGWQSPRD WNKAQMLKAN GSEELFVPCS
     CYNSTATNDS SGFDKLFLSQ LSRLGPRAKL RQTADICALP AKAHIYREGC ARSLQKWLHN
     NIISIVGICL GVGLLELGFM TLSIFLCRNL DHVYDRLARY R