CD3E_CHICK
ID CD3E_CHICK Reviewed; 175 AA.
AC Q98910;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=T-cell surface glycoprotein CD3 epsilon chain;
DE AltName: CD_antigen=CD3e;
DE Flags: Precursor;
GN Name=CD3E;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CB; TISSUE=Blood;
RX PubMed=9022018; DOI=10.1002/eji.1830270129;
RA Gobel T.W.F., Fluri M.;
RT "Identification and analysis of the chicken CD3epsilon gene.";
RL Eur. J. Immunol. 27:194-198(1997).
CC -!- FUNCTION: The CD3 complex mediates signal transduction, resulting in T-
CC cell activation and proliferation. Required for normal immune
CC responses. {ECO:0000250|UniProtKB:P07766}.
CC -!- SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR
CC alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell
CC surface with the invariant subunits of CD3 labeled gamma, delta,
CC epsilon, zeta, and eta. {ECO:0000250|UniProtKB:P07766}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P07766};
CC Single-pass type I membrane protein {ECO:0000250|UniProtKB:P07766}.
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DR EMBL; Y08917; CAA70121.1; -; mRNA.
DR AlphaFoldDB; Q98910; -.
DR SMR; Q98910; -.
DR STRING; 9031.ENSGALP00000011982; -.
DR PaxDb; Q98910; -.
DR VEuPathDB; HostDB:geneid_396062; -.
DR eggNOG; ENOG502S8KB; Eukaryota.
DR InParanoid; Q98910; -.
DR PhylomeDB; Q98910; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0042105; C:alpha-beta T cell receptor complex; IEA:UniProt.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR015484; CD3_esu/gsu/dsu.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
DR PANTHER; PTHR10570; PTHR10570; 1.
DR SMART; SM00077; ITAM; 1.
DR PROSITE; PS51055; ITAM_1; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Immunity; Immunoglobulin domain; Membrane; Receptor;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..175
FT /note="T-cell surface glycoprotein CD3 epsilon chain"
FT /id="PRO_0000014613"
FT TOPO_DOM 22..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..175
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 146..173
FT /note="ITAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00379"
FT REGION 133..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 175 AA; 19062 MW; 5D7F57E890D13B72 CRC64;
MRCEVPLPLL GLLLCVVGAA AQGGQEEFAV EISGTTVTIT CPSSGDDVKW KPDPKMVVNN
KYIIQNHDSS PLTVSCTAGD EEHTMYLNAK VCANCEELDT FTVVGIIAAD LLITLGVLIL
VYYFSKNKKG QSRAAAGSRP RAQKMRRPPP VPNPDYEPIR KGQRDVYAGL EHRGF
