CD48C_ARATH
ID CD48C_ARATH Reviewed; 820 AA.
AC Q9SS94; Q8L769;
DT 01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2003, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Cell division control protein 48 homolog C;
DE Short=AtCDC48c;
DE AltName: Full=Protein EMBRYO DEFECTIVE 1354;
GN Name=CDC48C; Synonyms=EMB1354; OrderedLocusNames=At3g01610;
GN ORFNames=F4P13.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: Probably functions in cell division and growth processes.
CC Interacts with certain SNAREs as part of specialized membrane fusion
CC events where vesicles from the same organelle fuse (homotypic fusion)
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC phragmoplast {ECO:0000250}. Note=Primarily localized to the nucleus
CC and, during cytokinesis, to the phragmoplast, a site where membrane
CC vesicles are targeted in the deposition of new cell wall materials.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR EMBL; AC009325; AAF01545.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE73695.1; -; Genomic_DNA.
DR EMBL; AY136443; AAM97108.1; -; mRNA.
DR EMBL; BT002135; AAN72146.1; -; mRNA.
DR RefSeq; NP_186810.2; NM_111027.4.
DR AlphaFoldDB; Q9SS94; -.
DR SMR; Q9SS94; -.
DR BioGRID; 6438; 3.
DR IntAct; Q9SS94; 1.
DR STRING; 3702.AT3G01610.1; -.
DR TCDB; 3.A.16.1.5; the endoplasmic reticular retrotranslocon (er-rt) family.
DR iPTMnet; Q9SS94; -.
DR PaxDb; Q9SS94; -.
DR PRIDE; Q9SS94; -.
DR ProteomicsDB; 223920; -.
DR EnsemblPlants; AT3G01610.1; AT3G01610.1; AT3G01610.
DR GeneID; 821105; -.
DR Gramene; AT3G01610.1; AT3G01610.1; AT3G01610.
DR KEGG; ath:AT3G01610; -.
DR Araport; AT3G01610; -.
DR TAIR; locus:2084163; AT3G01610.
DR eggNOG; KOG0733; Eukaryota.
DR HOGENOM; CLU_000688_8_3_1; -.
DR InParanoid; Q9SS94; -.
DR OMA; XILQTLC; -.
DR PhylomeDB; Q9SS94; -.
DR PRO; PR:Q9SS94; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SS94; baseline and differential.
DR Genevisible; Q9SS94; AT.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0009524; C:phragmoplast; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:1990275; F:preribosome binding; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051973; P:positive regulation of telomerase activity; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042254; P:ribosome biogenesis; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00674; AAA; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW Cytoskeleton; Nucleotide-binding; Nucleus; Protein transport;
KW Reference proteome; Repeat; Transport.
FT CHAIN 1..820
FT /note="Cell division control protein 48 homolog C"
FT /id="PRO_0000084581"
FT REGION 72..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 85..122
FT /evidence="ECO:0000255"
FT COMPBIAS 85..119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 274..281
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 569..576
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 7
FT /note="Missing (in Ref. 3; AAN72146)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 820 AA; 90005 MW; A9B46C26779DA8C9 CRC64;
MGRRGRGGGG GMGGGINRRY LSQVMDTCGK DLSTAEDIVD DLRSRYGNFA RLTRQVLLLN
VRQVLNVRNN KRVKDEDEDD NIGDEEGSAS QRKKQRRVDE KEEKLQRAEQ SHLRKRNMER
SVSSSPSSSS SSEDSGDVST SEDAVYGEKL SPPRFDLIND SLRDNYAKLN SSSKKPIGSP
AEKNVEVETV SNKGRSKLAT MGARKEAKVS LSLSGATGNG DLEVEGTKGP TFKDFGGIKK
ILDELEMNVL FPILNPEPFK KIGVKPPSGI LFHGPPGCGK TKLANAIANE AGVPFYKISA
TEVISGVSGA SEENIRELFS KAYRTAPSIV FIDEIDAIGS KRENQQREME KRIVTQLLTC
MDGPGNKGDK NAPDSSAGFV LVIGATNRPD ALDPALRRSG RFETEIALTA PDEDARAEIL
SVVAQKLRLE GPFDKKRIAR LTPGFVGADL ESVAYLAGRK AIKRILDSRK SEQSGDGEDD
KSWLRMPWPE EELEKLFVKM SDFEEAVNLV QASLTREGFS IVPDVKWDDV GGLDHLRLQF
NRYIVRPIKK PDIYKAFGVD LETGFLLYGP PGCGKTLIAK AAANEAGANF MHIKGAELLN
KYVGESELAI RTLFQRARTC APCVIFFDEV DALTTSRGKE GAWVVERLLN QFLVELDGGE
RRNVYVIGAT NRPDVVDPAF LRPGRFGNLL YVPLPNADER ASILKAIARK KPIDPSVDLD
GIAKNNCEGF SGADLAHLVQ KATFQAVEEM IGSSESSEDD VTDITQCTIK TRHFEQALSL
VSPSVNKQQR RHYDALSTKL QESVGRNTEQ VTIGPSFTLE
