ID   CD52_CANLF              Reviewed;          67 AA.
AC   Q28896;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=CAMPATH-1 antigen;
DE   AltName: Full=Epididymal secretory protein E5;
DE   AltName: CD_antigen=CD52;
DE   Flags: Precursor;
GN   Name=CD52; Synonyms=CDW52, CE5;
OS   Canis lupus familiaris (Dog) (Canis familiaris).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX   NCBI_TaxID=9615;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Epididymis;
RX   PubMed=7744511; DOI=10.1111/j.1365-2605.1994.tb01262.x;
RA   Ellerbrock K., Pera I., Hartung S., Ivell R.;
RT   "Gene expression in the dog epididymis: a model for human epididymal
RT   function.";
RL   Int. J. Androl. 17:314-323(1994).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=7744512; DOI=10.1111/j.1365-2605.1994.tb01263.x;
RA   Pera I., Ivell R., Kirchhoff C.;
RT   "Regional variation of specific gene expression in the dog epididymis as
RT   revealed by in-situ transcript hybridization.";
RL   Int. J. Androl. 17:324-330(1994).
CC   -!- FUNCTION: May play a role in carrying and orienting carbohydrate, as
CC       well as having a more specific role.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC   -!- TISSUE SPECIFICITY: Epididymis. Highest levels are found in the distal
CC       corpus and cauda. Little or no expression in the caput and proximal
CC       cauda regions. {ECO:0000269|PubMed:7744512}.
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DR   EMBL; S77412; AAB34265.1; -; mRNA.
DR   PIR; I69230; I69230.
DR   RefSeq; NP_001003240.1; NM_001003240.1.
DR   AlphaFoldDB; Q28896; -.
DR   STRING; 9612.ENSCAFP00000018435; -.
DR   PaxDb; Q28896; -.
DR   ABCD; Q28896; 1 sequenced antibody.
DR   Ensembl; ENSCAFT00030027530; ENSCAFP00030024023; ENSCAFG00030014935.
DR   Ensembl; ENSCAFT00040007980; ENSCAFP00040006951; ENSCAFG00040004179.
DR   Ensembl; ENSCAFT00845022339; ENSCAFP00845017564; ENSCAFG00845012550.
DR   GeneID; 403918; -.
DR   KEGG; cfa:403918; -.
DR   CTD; 1043; -.
DR   VEuPathDB; HostDB:ENSCAFG00845012550; -.
DR   eggNOG; ENOG502RR9C; Eukaryota.
DR   GeneTree; ENSGT00860000134004; -.
DR   HOGENOM; CLU_205433_0_0_1; -.
DR   InParanoid; Q28896; -.
DR   OMA; FFANTLM; -.
DR   Reactome; R-CFA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR   Proteomes; UP000002254; Chromosome 2.
DR   Bgee; ENSCAFG00000012520; Expressed in thymus and 30 other tissues.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0097225; C:sperm midpiece; IBA:GO_Central.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR   GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR   InterPro; IPR026643; CAMPATH-1.
DR   PANTHER; PTHR15029; PTHR15029; 1.
DR   Pfam; PF15116; CD52; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         26..45
FT                   /note="CAMPATH-1 antigen"
FT                   /id="PRO_0000020902"
FT   PROPEP          46..67
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000020903"
FT   LIPID           45
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        26
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   67 AA;  7160 MW;  3BD19E9C2143C4CA CRC64;
     MKGFLFLLLT ISLLVMIQIQ TGVLGNSTTP RMTTKKVKSA TPALSSLGGG SVLLFLANTL
     IQLFYLS