CD52_HUMAN
ID CD52_HUMAN Reviewed; 61 AA.
AC P31358; Q5T138; Q9BW46;
DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1993, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=CAMPATH-1 antigen;
DE AltName: Full=CDw52;
DE AltName: Full=Cambridge pathology 1 antigen;
DE AltName: Full=Epididymal secretory protein E5;
DE AltName: Full=Human epididymis-specific protein 5;
DE Short=He5;
DE AltName: CD_antigen=CD52;
DE Flags: Precursor;
GN Name=CD52; Synonyms=CDW52, HE5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 25-35.
RC TISSUE=Spleen;
RX PubMed=1711975; DOI=10.1002/eji.1830210714;
RA Xia M.-Q., Tone M., Packman L., Hale G., Waldmann H.;
RT "Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis
RT and cDNA cloning reveal an unusually small peptide backbone.";
RL Eur. J. Immunol. 21:1677-1684(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Epididymis;
RX PubMed=8418821; DOI=10.1002/mrd.1080340103;
RA Kirchhoff C., Krull N., Pera I., Ivell R.;
RT "A major mRNA of the human epididymal principal cells, HE5, encodes the
RT leucocyte differentiation CDw52 antigen peptide backbone.";
RL Mol. Reprod. Dev. 34:8-15(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP GPI-ANCHOR AT SER-36.
RX PubMed=7688956; DOI=10.1042/bj2930633;
RA Xia M.Q., Hale G., Lifely M.R., Ferguson M.A., Campbell D., Packman L.,
RA Waldmann H.;
RT "Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-
RT anchored glycoprotein which is an exceptionally good target for complement
RT lysis.";
RL Biochem. J. 293:633-640(1993).
CC -!- FUNCTION: May play a role in carrying and orienting carbohydrate, as
CC well as having a more specific role.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
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DR EMBL; X62466; CAA44323.1; -; mRNA.
DR EMBL; X67699; CAA47929.1; -; mRNA.
DR EMBL; AL451139; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC000644; AAH00644.1; -; mRNA.
DR CCDS; CCDS30647.1; -.
DR PIR; S18766; S18766.
DR RefSeq; NP_001794.2; NM_001803.2.
DR PDB; 6OBD; X-ray; 2.20 A; E/F=27-36.
DR PDBsum; 6OBD; -.
DR AlphaFoldDB; P31358; -.
DR SMR; P31358; -.
DR BioGRID; 107473; 6.
DR STRING; 9606.ENSP00000363330; -.
DR ChEMBL; CHEMBL1912; -.
DR DrugBank; DB00087; Alemtuzumab.
DR DrugCentral; P31358; -.
DR GlyGen; P31358; 2 sites.
DR BioMuta; CD52; -.
DR PaxDb; P31358; -.
DR PRIDE; P31358; -.
DR ABCD; P31358; 53 sequenced antibodies.
DR Antibodypedia; 16066; 771 antibodies from 33 providers.
DR DNASU; 1043; -.
DR Ensembl; ENST00000374213.3; ENSP00000363330.2; ENSG00000169442.9.
DR GeneID; 1043; -.
DR KEGG; hsa:1043; -.
DR MANE-Select; ENST00000374213.3; ENSP00000363330.2; NM_001803.3; NP_001794.2.
DR CTD; 1043; -.
DR DisGeNET; 1043; -.
DR GeneCards; CD52; -.
DR HGNC; HGNC:1804; CD52.
DR HPA; ENSG00000169442; Tissue enriched (epididymis).
DR MIM; 114280; gene.
DR neXtProt; NX_P31358; -.
DR OpenTargets; ENSG00000169442; -.
DR PharmGKB; PA26350; -.
DR VEuPathDB; HostDB:ENSG00000169442; -.
DR eggNOG; ENOG502RR9C; Eukaryota.
DR GeneTree; ENSGT00860000134004; -.
DR HOGENOM; CLU_205433_0_0_1; -.
DR InParanoid; P31358; -.
DR OMA; FFANTLM; -.
DR PhylomeDB; P31358; -.
DR TreeFam; TF338573; -.
DR PathwayCommons; P31358; -.
DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR SignaLink; P31358; -.
DR SIGNOR; P31358; -.
DR BioGRID-ORCS; 1043; 15 hits in 1073 CRISPR screens.
DR ChiTaRS; CD52; human.
DR GeneWiki; CD52; -.
DR GenomeRNAi; 1043; -.
DR Pharos; P31358; Tclin.
DR PRO; PR:P31358; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; P31358; protein.
DR Bgee; ENSG00000169442; Expressed in corpus epididymis and 164 other tissues.
DR ExpressionAtlas; P31358; baseline and differential.
DR Genevisible; P31358; HS.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0031226; C:intrinsic component of plasma membrane; TAS:UniProtKB.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0097225; C:sperm midpiece; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:UniProtKB.
DR GO; GO:0045730; P:respiratory burst; NAS:UniProtKB.
DR InterPro; IPR026643; CAMPATH-1.
DR PANTHER; PTHR15029; PTHR15029; 1.
DR Pfam; PF15116; CD52; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Direct protein sequencing; Glycoprotein;
KW GPI-anchor; Lipoprotein; Membrane; Reference proteome; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000269|PubMed:1711975"
FT PEPTIDE 25..36
FT /note="CAMPATH-1 antigen"
FT /id="PRO_0000020904"
FT PROPEP 37..61
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000020905"
FT LIPID 36
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000269|PubMed:7688956"
FT CARBOHYD 27
FT /note="N-linked (GlcNAc...) asparagine"
FT CARBOHYD 40
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 40
FT /note="N -> S (in dbSNP:rs1071849)"
FT /id="VAR_050775"
FT VARIANT 41
FT /note="I -> M (in dbSNP:rs17645)"
FT /id="VAR_014838"
SQ SEQUENCE 61 AA; 6614 MW; 4AE2A056682BEEA6 CRC64;
MKRFLFLLLT ISLLVMVQIQ TGLSGQNDTS QTSSPSASSN ISGGIFLFFV ANAIIHLFCF
S
