ID   CD52_MACFA              Reviewed;          60 AA.
AC   P32763;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=CAMPATH-1 antigen;
DE   AltName: Full=Cambridge pathology 1 antigen;
DE   AltName: CD_antigen=CD52;
DE   Flags: Precursor;
GN   Name=CD52; Synonyms=CDW52;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Epididymis;
RX   PubMed=1384718; DOI=10.1016/0167-4781(92)90152-p;
RA   Perry A.C.F., Jones R., Hall L.;
RT   "Identification of an abundant monkey epididymal transcript encoding a
RT   homologue of human CAMPATH-1 antigen precursor.";
RL   Biochim. Biophys. Acta 1171:122-124(1992).
CC   -!- FUNCTION: May play a role in carrying and orienting carbohydrate, as
CC       well as having a more specific role.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
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DR   EMBL; X67495; CAA47833.1; -; mRNA.
DR   PIR; S27152; S27152.
DR   RefSeq; XP_005544396.1; XM_005544339.1.
DR   AlphaFoldDB; P32763; -.
DR   SMR; P32763; -.
DR   STRING; 9541.XP_005544396.1; -.
DR   Ensembl; ENSMFAT00000002889; ENSMFAP00000028698; ENSMFAG00000041646.
DR   GeneID; 102144354; -.
DR   KEGG; mcf:102144354; -.
DR   CTD; 1043; -.
DR   VEuPathDB; HostDB:ENSMFAG00000041646; -.
DR   eggNOG; ENOG502RR9C; Eukaryota.
DR   GeneTree; ENSGT00860000134004; -.
DR   OMA; FFANTLM; -.
DR   Proteomes; UP000233100; Chromosome 1.
DR   Bgee; ENSMFAG00000041646; Expressed in bone marrow and 13 other tissues.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   InterPro; IPR026643; CAMPATH-1.
DR   PANTHER; PTHR15029; PTHR15029; 1.
DR   Pfam; PF15116; CD52; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         25..35
FT                   /note="CAMPATH-1 antigen"
FT                   /id="PRO_0000020906"
FT   PROPEP          36..60
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000020907"
FT   LIPID           35
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        27
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   60 AA;  6503 MW;  66EFBECCA910CBF9 CRC64;
     MKRFLFLLLT ISLLVMVQIQ TGVTSQNATS QSSPSASSNL SGGGFLFFVA NAIIHLFYFS