CD52_MOUSE
ID CD52_MOUSE Reviewed; 74 AA.
AC Q64389;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=CAMPATH-1 antigen;
DE AltName: Full=Lymphocyte differentiation antigen B7;
DE AltName: CD_antigen=CD52;
DE Flags: Precursor;
GN Name=Cd52; Synonyms=Cdw52, Mb7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2147207;
RA Kubota H., Okazaki H., Onuma M., Kano S., Hattori M., Minato N.;
RT "Identification and gene cloning of a new phosphatidylinositol-linked
RT antigen expressed on mature lymphocytes. Down-regulation by lymphocyte
RT activation.";
RL J. Immunol. 145:3924-3931(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Epididymis;
RX PubMed=7515288; DOI=10.1095/biolreprod50.4.896;
RA Kirchhoff C.;
RT "A major messenger ribonucleic acid of the rodent epididymis encodes a
RT small glycosylphosphatidylinositol-anchored lymphocyte surface antigen.";
RL Biol. Reprod. 50:896-902(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in carrying and orienting carbohydrate, as
CC well as having a more specific role.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC -!- TISSUE SPECIFICITY: Expressed on lymphohematopoietic tissues, including
CC thymus, spleen, and bone marrow, but not in liver, kidney, and brain.
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DR EMBL; M55561; AAA39889.1; -; mRNA.
DR EMBL; X76696; CAA54125.1; -; mRNA.
DR EMBL; AK088161; BAC40183.1; -; mRNA.
DR EMBL; BC027495; AAH27495.1; -; mRNA.
DR CCDS; CCDS38909.1; -.
DR PIR; I48263; I48263.
DR RefSeq; NP_038734.1; NM_013706.2.
DR AlphaFoldDB; Q64389; -.
DR IntAct; Q64389; 2.
DR STRING; 10090.ENSMUSP00000000696; -.
DR GlyGen; Q64389; 1 site.
DR PaxDb; Q64389; -.
DR PRIDE; Q64389; -.
DR Antibodypedia; 16066; 771 antibodies from 33 providers.
DR DNASU; 23833; -.
DR Ensembl; ENSMUST00000000696; ENSMUSP00000000696; ENSMUSG00000000682.
DR GeneID; 23833; -.
DR KEGG; mmu:23833; -.
DR UCSC; uc008vea.2; mouse.
DR CTD; 1043; -.
DR MGI; MGI:1346088; Cd52.
DR VEuPathDB; HostDB:ENSMUSG00000000682; -.
DR GeneTree; ENSGT00860000134004; -.
DR HOGENOM; CLU_183901_0_0_1; -.
DR InParanoid; Q64389; -.
DR OMA; FFANTLM; -.
DR OrthoDB; 1646255at2759; -.
DR TreeFam; TF338573; -.
DR Reactome; R-MMU-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR BioGRID-ORCS; 23833; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Cd52; mouse.
DR PRO; PR:Q64389; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q64389; protein.
DR Bgee; ENSMUSG00000000682; Expressed in seminal vesicle and 170 other tissues.
DR Genevisible; Q64389; MM.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097225; C:sperm midpiece; IDA:MGI.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR InterPro; IPR026643; CAMPATH-1.
DR PANTHER; PTHR15029; PTHR15029; 1.
DR Pfam; PF15116; CD52; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PEPTIDE 24..47
FT /note="CAMPATH-1 antigen"
FT /id="PRO_0000020908"
FT PROPEP 48..74
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000020909"
FT REGION 26..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 47
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 74 AA; 7798 MW; E106F479AC481925 CRC64;
MKSFLLFLTI ILLVVIQIQT GSLGQATTAA SGTNKNSTST KKTPLKSGAS SIIDAGACSF
LFFANTLMCL FYLS
