ID   CD52_RAT                Reviewed;          96 AA.
AC   Q63064;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=CAMPATH-1 antigen;
DE   AltName: Full=Lymphocyte differentiation antigen B7;
DE   AltName: CD_antigen=CD52;
DE   Flags: Precursor;
GN   Name=Cd52; Synonyms=Cdw52, Rb7;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Epididymis;
RX   PubMed=7515288; DOI=10.1095/biolreprod50.4.896;
RA   Kirchhoff C.;
RT   "A major messenger ribonucleic acid of the rodent epididymis encodes a
RT   small glycosylphosphatidylinositol-anchored lymphocyte surface antigen.";
RL   Biol. Reprod. 50:896-902(1994).
CC   -!- FUNCTION: May play a role in carrying and orienting carbohydrate, as
CC       well as having a more specific role.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
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DR   EMBL; X76697; CAA54126.1; -; mRNA.
DR   PIR; I84696; S40081.
DR   RefSeq; NP_446435.1; NM_053983.1.
DR   AlphaFoldDB; Q63064; -.
DR   STRING; 10116.ENSRNOP00000020688; -.
DR   GlyGen; Q63064; 1 site.
DR   PaxDb; Q63064; -.
DR   GeneID; 117054; -.
DR   KEGG; rno:117054; -.
DR   UCSC; RGD:620627; rat.
DR   CTD; 1043; -.
DR   RGD; 620627; Cd52.
DR   eggNOG; ENOG502TM88; Eukaryota.
DR   InParanoid; Q63064; -.
DR   OrthoDB; 1646255at2759; -.
DR   Reactome; R-RNO-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR   PRO; PR:Q63064; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0097225; C:sperm midpiece; ISO:RGD.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:RGD.
DR   GO; GO:0009617; P:response to bacterium; ISO:RGD.
DR   InterPro; IPR026643; CAMPATH-1.
DR   PANTHER; PTHR15029; PTHR15029; 1.
DR   Pfam; PF15116; CD52; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         24..70
FT                   /note="CAMPATH-1 antigen"
FT                   /id="PRO_0000020910"
FT   PROPEP          71..96
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000020911"
FT   LIPID           70
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        26
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   96 AA;  9829 MW;  FF195E03287C6FFB CRC64;
     MNTFLLLLTI SLLVVVQIQT GDLGQNSTAV TTPANKAATT AAATTKAAAT TATKTTTAVR
     KTPGKPPKAG ASSITDVGAC TFLFFANTLM CLFYLS