ID   CD53_BOVIN              Reviewed;         219 AA.
AC   Q58DM3;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Leukocyte surface antigen CD53;
DE   AltName: Full=Cell surface glycoprotein CD53;
DE   AltName: CD_antigen=CD53;
GN   Name=CD53;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for efficient formation of myofibers in regenerating
CC       muscle at the level of cell fusion. May be involved in growth
CC       regulation in hematopoietic cells (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SCIMP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cell junction
CC       {ECO:0000250}. Membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Note=Concentrates in localized microdomains along the
CC       plasma membrane at the contact sites between cells of fused myotubes.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR   EMBL; BT021574; AAX46421.1; -; mRNA.
DR   EMBL; BC113322; AAI13323.1; -; mRNA.
DR   RefSeq; NP_001029404.1; NM_001034232.2.
DR   AlphaFoldDB; Q58DM3; -.
DR   SMR; Q58DM3; -.
DR   STRING; 9913.ENSBTAP00000008479; -.
DR   PaxDb; Q58DM3; -.
DR   PRIDE; Q58DM3; -.
DR   Ensembl; ENSBTAT00000008479; ENSBTAP00000008479; ENSBTAG00000006466.
DR   GeneID; 505040; -.
DR   KEGG; bta:505040; -.
DR   CTD; 963; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006466; -.
DR   VGNC; VGNC:27039; CD53.
DR   eggNOG; KOG3882; Eukaryota.
DR   GeneTree; ENSGT00940000159669; -.
DR   HOGENOM; CLU_055524_4_3_1; -.
DR   InParanoid; Q58DM3; -.
DR   OMA; SFLHCCG; -.
DR   OrthoDB; 1224210at2759; -.
DR   TreeFam; TF352892; -.
DR   Reactome; R-BTA-6798695; Neutrophil degranulation.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000006466; Expressed in monocyte and 104 other tissues.
DR   GO; GO:0005911; C:cell-cell junction; ISS:UniProtKB.
DR   GO; GO:0001772; C:immunological synapse; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:1901741; P:positive regulation of myoblast fusion; ISS:UniProtKB.
DR   Gene3D; 1.10.1450.10; -; 1.
DR   InterPro; IPR018499; Tetraspanin/Peripherin.
DR   InterPro; IPR000301; Tetraspanin_animals.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2_sf.
DR   PANTHER; PTHR19282; PTHR19282; 1.
DR   Pfam; PF00335; Tetraspanin; 1.
DR   PIRSF; PIRSF002419; Tetraspanin; 1.
DR   SUPFAM; SSF48652; SSF48652; 1.
DR   PROSITE; PS00421; TM4_1; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..219
FT                   /note="Leukocyte surface antigen CD53"
FT                   /id="PRO_0000237572"
FT   TOPO_DOM        1..11
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        33..54
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        70..80
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        107..181
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..219
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        129
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        148
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   219 AA;  24103 MW;  B3FFEBDB8281946C CRC64;
     MGMSSLKLLK FVLFFFNLIF WFCGCCILGL GIYLLIHSKF GVLFHNLPSL TLGNVLVIVG
     SVIMVVAFLG CMGSIKENKC LLMSFFVLLL IILLAEVTLA ILLFVYEQKL KEYVAEGLTE
     SIQRYNSDNS TKAAWDSIQS FLQCCGVNGT SDWTSGPPAS CPKGSAVKGC YIQAKQWFHS
     NFLYIGITTI CVCVIQVLGM SFALTLNCQI DKTSQVLGL