CD53_HUMAN
ID CD53_HUMAN Reviewed; 219 AA.
AC P19397; B2R905; Q5U0D6;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Leukocyte surface antigen CD53;
DE AltName: Full=Cell surface glycoprotein CD53;
DE AltName: Full=Tetraspanin-25;
DE Short=Tspan-25;
DE AltName: CD_antigen=CD53;
GN Name=CD53; Synonyms=MOX44, TSPAN25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1700763; DOI=10.1007/bf00187099;
RA Angelisova P., Vlcek C., Stefanova I., Lipoldova M., Horejsi V.;
RT "The human leucocyte surface antigen CD53 is a protein structurally similar
RT to the CD37 and MRC OX-44 antigens.";
RL Immunogenetics 32:281-285(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2258620;
RA Amiot M.;
RT "Identification and analysis of cDNA clones encoding CD53. A pan-leukocyte
RT antigen related to membrane transport proteins.";
RL J. Immunol. 145:4322-4325(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP INTERACTION WITH SCIMP.
RX PubMed=21930792; DOI=10.1128/mcb.05817-11;
RA Draber P., Vonkova I., Stepanek O., Hrdinka M., Kucova M., Skopcova T.,
RA Otahal P., Angelisova P., Horejsi V., Yeung M., Weiss A., Brdicka T.;
RT "SCIMP, a transmembrane adapter protein involved in major
RT histocompatibility complex class II signaling.";
RL Mol. Cell. Biol. 31:4550-4562(2011).
CC -!- FUNCTION: Required for efficient formation of myofibers in regenerating
CC muscle at the level of cell fusion. May be involved in growth
CC regulation in hematopoietic cells (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SCIMP. {ECO:0000269|PubMed:21930792}.
CC -!- INTERACTION:
CC P19397; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-6657396, EBI-11957045;
CC P19397; P05090: APOD; NbExp=3; IntAct=EBI-6657396, EBI-715495;
CC P19397; Q3SXY8: ARL13B; NbExp=3; IntAct=EBI-6657396, EBI-11343438;
CC P19397; P07307-3: ASGR2; NbExp=3; IntAct=EBI-6657396, EBI-12808270;
CC P19397; P27449: ATP6V0C; NbExp=3; IntAct=EBI-6657396, EBI-721179;
CC P19397; Q9BXK5: BCL2L13; NbExp=3; IntAct=EBI-6657396, EBI-747430;
CC P19397; Q13323: BIK; NbExp=3; IntAct=EBI-6657396, EBI-700794;
CC P19397; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-6657396, EBI-8648738;
CC P19397; Q86Z23: C1QL4; NbExp=3; IntAct=EBI-6657396, EBI-12062109;
CC P19397; Q8IX05: CD302; NbExp=3; IntAct=EBI-6657396, EBI-14259393;
CC P19397; P11049: CD37; NbExp=3; IntAct=EBI-6657396, EBI-6139068;
CC P19397; P19397: CD53; NbExp=3; IntAct=EBI-6657396, EBI-6657396;
CC P19397; P51798: CLCN7; NbExp=3; IntAct=EBI-6657396, EBI-4402346;
CC P19397; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-6657396, EBI-12256978;
CC P19397; O95471: CLDN7; NbExp=3; IntAct=EBI-6657396, EBI-740744;
CC P19397; Q9BXN2-6: CLEC7A; NbExp=3; IntAct=EBI-6657396, EBI-11989440;
CC P19397; O95406: CNIH1; NbExp=3; IntAct=EBI-6657396, EBI-12172273;
CC P19397; Q6PI25: CNIH2; NbExp=3; IntAct=EBI-6657396, EBI-12815321;
CC P19397; P29400-2: COL4A5; NbExp=3; IntAct=EBI-6657396, EBI-12211159;
CC P19397; Q96BA8: CREB3L1; NbExp=5; IntAct=EBI-6657396, EBI-6942903;
CC P19397; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-6657396, EBI-12019274;
CC P19397; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-6657396, EBI-2680384;
CC P19397; P0DPD6-3: ECE2; NbExp=3; IntAct=EBI-6657396, EBI-19128181;
CC P19397; P52803: EFNA5; NbExp=3; IntAct=EBI-6657396, EBI-1753674;
CC P19397; P54849: EMP1; NbExp=3; IntAct=EBI-6657396, EBI-4319440;
CC P19397; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-6657396, EBI-711490;
CC P19397; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-6657396, EBI-18304435;
CC P19397; O00258: GET1; NbExp=3; IntAct=EBI-6657396, EBI-18908258;
CC P19397; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-6657396, EBI-6166686;
CC P19397; P48165: GJA8; NbExp=3; IntAct=EBI-6657396, EBI-17458373;
CC P19397; Q9NPR9: GPR108; NbExp=3; IntAct=EBI-6657396, EBI-11343451;
CC P19397; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-6657396, EBI-13345167;
CC P19397; Q8TED1: GPX8; NbExp=3; IntAct=EBI-6657396, EBI-11721746;
CC P19397; Q01628: IFITM3; NbExp=3; IntAct=EBI-6657396, EBI-7932862;
CC P19397; P24593: IGFBP5; NbExp=3; IntAct=EBI-6657396, EBI-720480;
CC P19397; Q8N743: KIR3DL3; NbExp=3; IntAct=EBI-6657396, EBI-17272405;
CC P19397; O43561-2: LAT; NbExp=3; IntAct=EBI-6657396, EBI-8070286;
CC P19397; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-6657396, EBI-2820517;
CC P19397; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-6657396, EBI-12033434;
CC P19397; Q8N8F7: LSMEM1; NbExp=3; IntAct=EBI-6657396, EBI-10200825;
CC P19397; P21145: MAL; NbExp=3; IntAct=EBI-6657396, EBI-3932027;
CC P19397; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-6657396, EBI-12806656;
CC P19397; P15941-11: MUC1; NbExp=3; IntAct=EBI-6657396, EBI-17263240;
CC P19397; Q16617: NKG7; NbExp=3; IntAct=EBI-6657396, EBI-3919611;
CC P19397; P26678: PLN; NbExp=3; IntAct=EBI-6657396, EBI-692836;
CC P19397; Q04941: PLP2; NbExp=3; IntAct=EBI-6657396, EBI-608347;
CC P19397; Q01453: PMP22; NbExp=3; IntAct=EBI-6657396, EBI-2845982;
CC P19397; Q9NS64: RPRM; NbExp=3; IntAct=EBI-6657396, EBI-1052363;
CC P19397; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-6657396, EBI-3920694;
CC P19397; A2A2V5: SERTM1; NbExp=3; IntAct=EBI-6657396, EBI-17284533;
CC P19397; P78382: SLC35A1; NbExp=3; IntAct=EBI-6657396, EBI-12870360;
CC P19397; Q8TBB6: SLC7A14; NbExp=3; IntAct=EBI-6657396, EBI-5235586;
CC P19397; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-6657396, EBI-10226799;
CC P19397; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-6657396, EBI-741850;
CC P19397; Q6UX34: SNORC; NbExp=3; IntAct=EBI-6657396, EBI-11957067;
CC P19397; Q96JF0-2: ST6GAL2; NbExp=3; IntAct=EBI-6657396, EBI-12908338;
CC P19397; P0DN84: STRIT1; NbExp=3; IntAct=EBI-6657396, EBI-12200293;
CC P19397; P32856-2: STX2; NbExp=3; IntAct=EBI-6657396, EBI-11956649;
CC P19397; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-6657396, EBI-10694905;
CC P19397; Q9NV12: TMEM140; NbExp=3; IntAct=EBI-6657396, EBI-2844246;
CC P19397; A2RU14: TMEM218; NbExp=3; IntAct=EBI-6657396, EBI-10173151;
CC P19397; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-6657396, EBI-12195227;
CC P19397; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-6657396, EBI-10982110;
CC P19397; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-6657396, EBI-2852148;
CC P19397; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-6657396, EBI-2548832;
CC P19397; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-6657396, EBI-12111910;
CC P19397; Q8N609: TRAM1L1; NbExp=3; IntAct=EBI-6657396, EBI-11996766;
CC P19397; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-6657396, EBI-12195249;
CC P19397; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-6657396, EBI-11988865;
CC P19397; Q9Y5Z9: UBIAD1; NbExp=3; IntAct=EBI-6657396, EBI-2819725;
CC P19397; O75841: UPK1B; NbExp=3; IntAct=EBI-6657396, EBI-12237619;
CC P19397; O95183: VAMP5; NbExp=3; IntAct=EBI-6657396, EBI-10191195;
CC P19397; Q6UX27-3: VSTM1; NbExp=3; IntAct=EBI-6657396, EBI-12190699;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cell junction
CC {ECO:0000250}. Membrane; Multi-pass membrane protein. Note=Concentrates
CC in localized microdomains along the plasma membrane at the contact
CC sites between cells of fused myotubes. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: B-cells, monocytes, macrophages, neutrophils,
CC single (CD4 or CD8) positive thymocytes and peripheral T-cells.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/CD53ID983ch1p13.html";
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DR EMBL; M37033; AAA35663.1; -; mRNA.
DR EMBL; M60871; AAA51951.1; -; mRNA.
DR EMBL; BT019643; AAV38449.1; -; mRNA.
DR EMBL; AK313582; BAG36352.1; -; mRNA.
DR EMBL; AL391064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471122; EAW56459.1; -; Genomic_DNA.
DR EMBL; BC040693; AAH40693.1; -; mRNA.
DR CCDS; CCDS829.1; -.
DR PIR; A37243; A37243.
DR RefSeq; NP_000551.1; NM_000560.3.
DR RefSeq; NP_001035122.1; NM_001040033.1.
DR PDB; 6WVG; X-ray; 2.90 A; A/B=1-219.
DR PDBsum; 6WVG; -.
DR AlphaFoldDB; P19397; -.
DR SMR; P19397; -.
DR BioGRID; 107401; 108.
DR CORUM; P19397; -.
DR IntAct; P19397; 75.
DR STRING; 9606.ENSP00000271324; -.
DR TCDB; 8.A.40.1.18; the tetraspanin (tetraspanin) family.
DR GlyGen; P19397; 2 sites.
DR iPTMnet; P19397; -.
DR PhosphoSitePlus; P19397; -.
DR SwissPalm; P19397; -.
DR BioMuta; CD53; -.
DR DMDM; 116019; -.
DR jPOST; P19397; -.
DR MassIVE; P19397; -.
DR MaxQB; P19397; -.
DR PaxDb; P19397; -.
DR PeptideAtlas; P19397; -.
DR PRIDE; P19397; -.
DR ProteomicsDB; 53654; -.
DR Antibodypedia; 20101; 720 antibodies from 34 providers.
DR DNASU; 963; -.
DR Ensembl; ENST00000271324.6; ENSP00000271324.5; ENSG00000143119.14.
DR Ensembl; ENST00000648608.1; ENSP00000497382.1; ENSG00000143119.14.
DR GeneID; 963; -.
DR KEGG; hsa:963; -.
DR MANE-Select; ENST00000271324.6; ENSP00000271324.5; NM_000560.4; NP_000551.1.
DR UCSC; uc001dzx.4; human.
DR CTD; 963; -.
DR DisGeNET; 963; -.
DR GeneCards; CD53; -.
DR HGNC; HGNC:1686; CD53.
DR HPA; ENSG00000143119; Tissue enhanced (lymphoid).
DR MIM; 151525; gene.
DR neXtProt; NX_P19397; -.
DR OpenTargets; ENSG00000143119; -.
DR PharmGKB; PA26225; -.
DR VEuPathDB; HostDB:ENSG00000143119; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000159669; -.
DR HOGENOM; CLU_055524_4_3_1; -.
DR InParanoid; P19397; -.
DR OMA; SFLHCCG; -.
DR PhylomeDB; P19397; -.
DR TreeFam; TF352892; -.
DR PathwayCommons; P19397; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; P19397; -.
DR BioGRID-ORCS; 963; 12 hits in 1078 CRISPR screens.
DR ChiTaRS; CD53; human.
DR GeneWiki; CD53; -.
DR GenomeRNAi; 963; -.
DR Pharos; P19397; Tbio.
DR PRO; PR:P19397; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; P19397; protein.
DR Bgee; ENSG00000143119; Expressed in blood and 194 other tissues.
DR Genevisible; P19397; HS.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005911; C:cell-cell junction; ISS:UniProtKB.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0001772; C:immunological synapse; IDA:UniProtKB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0035579; C:specific granule membrane; TAS:Reactome.
DR GO; GO:0070821; C:tertiary granule membrane; TAS:Reactome.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; NAS:ProtInc.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell junction; Cell membrane; Glycoprotein; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..219
FT /note="Leukocyte surface antigen CD53"
FT /id="PRO_0000219212"
FT TOPO_DOM 1..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT HELIX 9..37
FT /evidence="ECO:0007829|PDB:6WVG"
FT HELIX 52..76
FT /evidence="ECO:0007829|PDB:6WVG"
FT HELIX 79..105
FT /evidence="ECO:0007829|PDB:6WVG"
FT HELIX 107..123
FT /evidence="ECO:0007829|PDB:6WVG"
FT TURN 124..127
FT /evidence="ECO:0007829|PDB:6WVG"
FT HELIX 129..142
FT /evidence="ECO:0007829|PDB:6WVG"
FT STRAND 146..149
FT /evidence="ECO:0007829|PDB:6WVG"
FT HELIX 150..152
FT /evidence="ECO:0007829|PDB:6WVG"
FT STRAND 159..161
FT /evidence="ECO:0007829|PDB:6WVG"
FT HELIX 170..180
FT /evidence="ECO:0007829|PDB:6WVG"
FT HELIX 182..208
FT /evidence="ECO:0007829|PDB:6WVG"
SQ SEQUENCE 219 AA; 24341 MW; 48D4633DBC9110B6 CRC64;
MGMSSLKLLK YVLFFFNLLF WICGCCILGF GIYLLIHNNF GVLFHNLPSL TLGNVFVIVG
SIIMVVAFLG CMGSIKENKC LLMSFFILLL IILLAEVTLA ILLFVYEQKL NEYVAKGLTD
SIHRYHSDNS TKAAWDSIQS FLQCCGINGT SDWTSGPPAS CPSDRKVEGC YAKARLWFHS
NFLYIGIITI CVCVIEVLGM SFALTLNCQI DKTSQTIGL
