CD53_MOUSE
ID CD53_MOUSE Reviewed; 219 AA.
AC Q61451; Q61721;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Leukocyte surface antigen CD53;
DE AltName: Full=Cell surface glycoprotein CD53;
DE AltName: CD_antigen=CD53;
GN Name=Cd53;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Sv;
RX PubMed=8452817; DOI=10.1093/intimm/5.2.209;
RA Wright M.D., Rochelle J.M., Tomlinson M.G., Seldin M.F., Williams A.F.;
RT "Gene structure, chromosomal localization, and protein sequence of mouse
RT CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene
RT duplication.";
RL Int. Immunol. 5:209-216(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hematopoietic, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=22847234; DOI=10.1093/jmcb/mjs045;
RA Liu Q.C., Zha X.H., Faralli H., Yin H., Louis-Jeune C., Perdiguero E.,
RA Pranckeviciene E., Munoz-Canoves P., Rudnicki M.A., Brand M.,
RA Perez-Iratxeta C., Dilworth F.J.;
RT "Comparative expression profiling identifies differential roles for
RT Myogenin and p38alpha MAPK signaling in myogenesis.";
RL J. Mol. Cell Biol. 4:386-397(2012).
CC -!- FUNCTION: Required for efficient formation of myofibers in regenerating
CC muscle at the level of cell fusion. May be involved in growth
CC regulation in hematopoietic cells. {ECO:0000269|PubMed:22847234}.
CC -!- SUBUNIT: Interacts with SCIMP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22847234}. Cell
CC junction {ECO:0000269|PubMed:22847234}. Membrane
CC {ECO:0000269|PubMed:22847234}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:22847234}. Note=Concentrates in localized
CC microdomains along the plasma membrane at the contact sites between
CC cells of fused myotubes.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; X97227; CAA65864.1; -; mRNA.
DR EMBL; Z16078; CAA78892.1; -; Genomic_DNA.
DR EMBL; BC021310; AAH21310.1; -; mRNA.
DR EMBL; BC052905; AAH52905.1; -; mRNA.
DR CCDS; CCDS17728.1; -.
DR RefSeq; NP_031677.1; NM_007651.3.
DR AlphaFoldDB; Q61451; -.
DR SMR; Q61451; -.
DR STRING; 10090.ENSMUSP00000035781; -.
DR GlyGen; Q61451; 3 sites.
DR PhosphoSitePlus; Q61451; -.
DR PaxDb; Q61451; -.
DR PRIDE; Q61451; -.
DR Antibodypedia; 20101; 720 antibodies from 34 providers.
DR DNASU; 12508; -.
DR Ensembl; ENSMUST00000038845; ENSMUSP00000035781; ENSMUSG00000040747.
DR GeneID; 12508; -.
DR KEGG; mmu:12508; -.
DR UCSC; uc008qwm.2; mouse.
DR CTD; 963; -.
DR MGI; MGI:88341; Cd53.
DR VEuPathDB; HostDB:ENSMUSG00000040747; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000159669; -.
DR HOGENOM; CLU_055524_4_3_1; -.
DR InParanoid; Q61451; -.
DR OMA; SFLHCCG; -.
DR OrthoDB; 1224210at2759; -.
DR PhylomeDB; Q61451; -.
DR TreeFam; TF352892; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 12508; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Cd53; mouse.
DR PRO; PR:Q61451; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q61451; protein.
DR Bgee; ENSMUSG00000040747; Expressed in granulocyte and 207 other tissues.
DR ExpressionAtlas; Q61451; baseline and differential.
DR Genevisible; Q61451; MM.
DR GO; GO:0009986; C:cell surface; ISO:MGI.
DR GO; GO:0005911; C:cell-cell junction; IDA:UniProtKB.
DR GO; GO:0001772; C:immunological synapse; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; IDA:UniProtKB.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 2: Evidence at transcript level;
KW Cell junction; Cell membrane; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..219
FT /note="Leukocyte surface antigen CD53"
FT /id="PRO_0000219213"
FT TOPO_DOM 1..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 119
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 219 AA; 24164 MW; 7995D2E745A17AC0 CRC64;
MGMSSLKLLK YVLFIFNLLF WVCGCCILGF GIYFLVQNTY GVLFRNLPFL TLGNILVIVG
SIIMVVAFLG CMGSIKENKC LLMSFFVLLL IILLAEVTIA ILLFVYEQKL NTLVAEGLND
SIQHYHSDNS TMKAWDFIQT QLQCCGVNGS SDWTSGPPSS CPSGADVQGC YNKAKSWFHS
NFLYIGIITI CVCVIQVLGM SFALTLNCQI DKTSQALGL
