CD53_RAT
ID CD53_RAT Reviewed; 219 AA.
AC P24485;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Leukocyte surface antigen CD53;
DE AltName: Full=Cell surface glycoprotein CD53;
DE AltName: Full=Leukocyte antigen MRC OX-44;
DE AltName: CD_antigen=CD53;
GN Name=Cd53; Synonyms=Ox-44;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2017181; DOI=10.1128/mcb.11.5.2864-2872.1991;
RA Bellacosa A., Lazo P.A., Bear S.E., Tsichlis P.N.;
RT "The rat leukocyte antigen MRC OX-44 is a member of a new family of cell
RT surface proteins which appear to be involved in growth regulation.";
RL Mol. Cell. Biol. 11:2864-2872(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PRELIMINARY PROTEIN SEQUENCE OF 2-30.
RX PubMed=2466944; DOI=10.1084/jem.169.4.1497;
RA Classon B.J., Williams A.F., Willis A.C., Seed B., Stamenkovic I.;
RT "The primary structure of the human leukocyte antigen CD37, a species
RT homologue of the rat MRC OX-44 antigen.";
RL J. Exp. Med. 169:1497-1502(1989).
CC -!- FUNCTION: Required for efficient formation of myofibers in regenerating
CC muscle at the level of cell fusion. May be involved in growth
CC regulation in hematopoietic cells (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SCIMP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cell junction
CC {ECO:0000250}. Membrane; Multi-pass membrane protein. Note=Concentrates
CC in localized microdomains along the plasma membrane at the contact
CC sites between cells of fused myotubes. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Spleen and thymus, B-cells, monocytes, macrophages,
CC neutrophils, single (CD4 or CD8) positive thymocytes, peripheral T-
CC cells.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M57276; AAA41775.1; -; mRNA.
DR EMBL; BC078900; AAH78900.1; -; mRNA.
DR PIR; A39574; A39574.
DR RefSeq; NP_036655.1; NM_012523.2.
DR AlphaFoldDB; P24485; -.
DR SMR; P24485; -.
DR STRING; 10116.ENSRNOP00000024344; -.
DR GlyGen; P24485; 3 sites.
DR PaxDb; P24485; -.
DR Ensembl; ENSRNOT00000024344; ENSRNOP00000024344; ENSRNOG00000017874.
DR GeneID; 24251; -.
DR KEGG; rno:24251; -.
DR UCSC; RGD:2310; rat.
DR CTD; 963; -.
DR RGD; 2310; Cd53.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000159669; -.
DR HOGENOM; CLU_055524_4_3_1; -.
DR InParanoid; P24485; -.
DR OMA; SFLHCCG; -.
DR OrthoDB; 1224210at2759; -.
DR PhylomeDB; P24485; -.
DR TreeFam; TF352892; -.
DR Reactome; R-RNO-6798695; Neutrophil degranulation.
DR PRO; PR:P24485; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000017874; Expressed in spleen and 19 other tissues.
DR Genevisible; P24485; RN.
DR GO; GO:0009986; C:cell surface; IDA:RGD.
DR GO; GO:0005911; C:cell-cell junction; ISS:UniProtKB.
DR GO; GO:0001772; C:immunological synapse; ISO:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:1901741; P:positive regulation of myoblast fusion; ISS:UniProtKB.
DR GO; GO:0040008; P:regulation of growth; NAS:RGD.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Cell junction; Cell membrane; Direct protein sequencing; Glycoprotein;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..219
FT /note="Leukocyte surface antigen CD53"
FT /id="PRO_0000219214"
FT TOPO_DOM 2..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..54
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..219
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 119
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 148
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 219 AA; 24168 MW; C73FC368311F172D CRC64;
MGMSSLKLLK YVLFFFNFLF WVCGCCILGF GIHLLVQNTY GILFRNLPFL TLGNVLVIVG
SIIMVVAFLG CMGSIKENKC LLMSFFVLLL LILLAEVTLA ILLFVYEKKI NTLVAEGLND
SIQHYHSDNS TRMAWDFIQS QLQCCGVNGS SDWISGPPSS CPSGADVQGC YKKGQAWFHS
NFLYIGIVTI CVCVIQVLGM SFALTLNCQI DKTSQALGL
