CD59_MACFA
ID CD59_MACFA Reviewed; 128 AA.
AC Q8SQ46; Q4R5M6; Q8SPI3;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=CD59 glycoprotein;
DE AltName: Full=MAC-inhibitory protein;
DE Short=MAC-IP;
DE AltName: Full=Membrane attack complex inhibition factor;
DE Short=MACIF;
DE AltName: Full=Protectin;
DE AltName: CD_antigen=CD59;
DE Flags: Precursor;
GN Name=CD59; ORFNames=QccE-13278, QmoA-10351, QnpA-17056;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PHE-72 AND LEU-96.
RC TISSUE=Medulla oblongata, and Parietal cortex;
RX PubMed=11991714; DOI=10.1006/geno.2002.6753;
RA Osada N., Kusuda J., Hirata M., Tanuma R., Hida M., Sugano S., Hirai M.,
RA Hashimoto K.;
RT "Search for genes positively selected during primate evolution by 5'-end-
RT sequence screening of cynomolgus monkey cDNAs.";
RL Genomics 79:657-662(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potent inhibitor of the complement membrane attack complex
CC (MAC) action. Acts by binding to the C8 and/or C9 complements of the
CC assembling MAC, thereby preventing incorporation of the multiple copies
CC of C9 required for complete formation of the osmolytic pore (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with T-cell surface antigen CD2. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
CC -!- PTM: N- and O-glycosylated. {ECO:0000250}.
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DR EMBL; AB072017; BAB86806.1; -; mRNA.
DR EMBL; AB072018; BAB86807.1; -; mRNA.
DR EMBL; AB169517; BAE01599.1; -; mRNA.
DR RefSeq; XP_015289596.1; XM_015434110.1.
DR AlphaFoldDB; Q8SQ46; -.
DR SMR; Q8SQ46; -.
DR STRING; 9541.XP_005578297.1; -.
DR GeneID; 101867071; -.
DR CTD; 966; -.
DR eggNOG; ENOG502SA4P; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001971; P:negative regulation of activation of membrane attack complex; IEA:InterPro.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR027101; CD59_glyco.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR PANTHER; PTHR10036:SF9; PTHR10036:SF9; 1.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000250"
FT CHAIN 26..102
FT /note="CD59 glycoprotein"
FT /id="PRO_0000036110"
FT PROPEP 103..128
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000036111"
FT DOMAIN 26..108
FT /note="UPAR/Ly6"
FT LIPID 102
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 28..51
FT /evidence="ECO:0000250"
FT DISULFID 31..38
FT /evidence="ECO:0000250"
FT DISULFID 44..64
FT /evidence="ECO:0000250"
FT DISULFID 70..88
FT /evidence="ECO:0000250"
FT DISULFID 89..94
FT /evidence="ECO:0000250"
FT VARIANT 72
FT /note="Y -> F"
FT /evidence="ECO:0000269|PubMed:11991714"
FT VARIANT 96
FT /note="F -> L"
FT /evidence="ECO:0000269|PubMed:11991714"
SQ SEQUENCE 128 AA; 14008 MW; 8867D956D63F6E52 CRC64;
MGIQGGSVLF GLLLVLAVFC HSGHSLQCYN CPNPTTDCKT AINCSSGFDT CLIARAGLQV
YNQCWKFANC NYNDISTLLK ESELRYFCCK KDLCNFNEQL ESGGTSLSEK TVVLLVTPLL
AAAWCLHP
