ID   CD59_SHEEP              Reviewed;          27 AA.
AC   P58020; Q9TRH4;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 1.
DT   23-FEB-2022, entry version 55.
DE   RecName: Full=CD59 glycoprotein;
DE   AltName: Full=Complement inhibitory protein;
DE            Short=CIP;
DE   AltName: Full=MAC-inhibitory protein;
DE            Short=MAC-IP;
DE   AltName: Full=Membrane attack complex inhibition factor;
DE            Short=MACIF;
DE   AltName: Full=Protectin;
DE   AltName: CD_antigen=CD59;
DE   Flags: Fragment;
GN   Name=CD59;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Erythrocyte;
RX   PubMed=7682985;
RA   van den Berg C.W., Harrison R.A., Morgan B.P.;
RT   "The sheep analogue of human CD59: purification and characterization of its
RT   complement inhibitory activity.";
RL   Immunology 78:349-357(1993).
CC   -!- FUNCTION: Potent inhibitor of the complement membrane attack complex
CC       (MAC) action. Acts by binding, in a species specific manner, to the C8
CC       and/or C9 complements of the assembling MAC, thereby preventing
CC       incorporation of the multiple copies of C9 required for complete
CC       formation of the osmolytic pore.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC   -!- TISSUE SPECIFICITY: Expressed in erythrocytes and lymphocytes. Not
CC       detected in platelets.
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DR   STRING; 9940.ENSOARP00000019219; -.
DR   eggNOG; ENOG502SA4P; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   GPI-anchor; Lipoprotein; Membrane; Reference proteome.
FT   CHAIN           <1..>27
FT                   /note="CD59 glycoprotein"
FT                   /id="PRO_0000187085"
FT   CARBOHYD        17
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   DISULFID        3..25
FT                   /evidence="ECO:0000305"
FT   DISULFID        6..12
FT                   /evidence="ECO:0000305"
FT   UNSURE          3
FT                   /note="Assigned by comparison with orthologs"
FT   UNSURE          6
FT                   /note="Assigned by comparison with orthologs"
FT   UNSURE          17
FT                   /note="Assigned by comparison with orthologs"
FT   UNSURE          18
FT                   /note="Assigned by comparison with orthologs"
FT   UNSURE          25
FT                   /note="Assigned by comparison with orthologs"
FT   NON_TER         1
FT   NON_TER         27
SQ   SEQUENCE   27 AA;  3027 MW;  92E6C978EC7663FE CRC64;
     LQCYSCINQV DCTSVINCTX NQDACLY