ID   CD59_SHV21              Reviewed;         121 AA.
AC   Q00996;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   23-FEB-2022, entry version 95.
DE   RecName: Full=Surface glycoprotein CD59 homolog;
DE   Flags: Precursor;
GN   Name=15;
OS   Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus.
OX   NCBI_TaxID=10383;
OH   NCBI_TaxID=9521; Saimiri sciureus (Common squirrel monkey).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1321287; DOI=10.1128/jvi.66.8.5047-5058.1992;
RA   Albrecht J.-C., Nicholas J., Biller D., Cameron K.R., Biesinger B.,
RA   Newman C., Wittmann S., Craxton M.A., Coleman H., Fleckenstein B.,
RA   Honess R.W.;
RT   "Primary structure of the herpesvirus saimiri genome.";
RL   J. Virol. 66:5047-5058(1992).
RN   [2]
RP   SIMILARITY TO CD59.
RX   PubMed=1382344; DOI=10.1016/0042-6822(92)91247-r;
RA   Albrecht J.-C., Nicolas J., Cameron K.R., Newman C., Fleckenstein B.,
RA   Honess R.W.;
RT   "Herpesvirus saimiri has a gene specifying a homologue of the cellular
RT   membrane glycoprotein CD59.";
RL   Virology 190:527-530(1992).
CC   -!- SUBCELLULAR LOCATION: Host cell membrane {ECO:0000250}; Lipid-anchor,
CC       GPI-anchor {ECO:0000250}.
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DR   EMBL; X64346; CAA45638.1; -; Genomic_DNA.
DR   EMBL; X64273; CAA45565.1; -; Genomic_DNA.
DR   RefSeq; NP_040217.1; NC_001350.1.
DR   SMR; Q00996; -.
DR   GeneID; 1682506; -.
DR   KEGG; vg:1682506; -.
DR   Proteomes; UP000000587; Genome.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001971; P:negative regulation of activation of membrane attack complex; IEA:InterPro.
DR   CDD; cd00117; LU; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR018363; CD59_antigen_CS.
DR   InterPro; IPR027101; CD59_glyco.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   PANTHER; PTHR10036:SF9; PTHR10036:SF9; 1.
DR   SMART; SM00134; LU; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00983; LY6_UPAR; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; GPI-anchor; Host cell membrane;
KW   Host membrane; Lipoprotein; Membrane; Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..96
FT                   /note="Surface glycoprotein CD59 homolog"
FT                   /id="PRO_0000036128"
FT   PROPEP          97..121
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036129"
FT   DOMAIN          20..104
FT                   /note="UPAR/Ly6"
FT   LIPID           96
FT                   /note="GPI-anchor amidated asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        24
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        22..45
FT                   /evidence="ECO:0000250"
FT   DISULFID        25..32
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..82
FT                   /evidence="ECO:0000250"
FT   DISULFID        83..88
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   121 AA;  13814 MW;  56A8BDC07B953AA3 CRC64;
     MYILFTLVLT FVFCKPIHSL QCYNCSHSTM QCTTSTSCTS NLDSCLIAKA GSGVYYRCWK
     FDDCSFKRIS NQLSETQLKY HCCKKNLCNV NKGIENIKRT ISDKALLLLA LFLVTAWNFP
     L