CD5R2_HUMAN
ID CD5R2_HUMAN Reviewed; 367 AA.
AC Q13319; Q4ZFW6;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Cyclin-dependent kinase 5 activator 2;
DE Short=CDK5 activator 2;
DE AltName: Full=Cyclin-dependent kinase 5 regulatory subunit 2;
DE AltName: Full=p39;
DE AltName: Full=p39I;
DE Flags: Precursor;
GN Name=CDK5R2; Synonyms=NCK5AI;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hippocampus;
RX PubMed=7592934; DOI=10.1074/jbc.270.45.26897;
RA Tang D., Yeung J., Lee K.-Y., Matsushita M., Matsui H., Tomizawa K.,
RA Hatase O., Wang J.H.;
RT "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator.";
RL J. Biol. Chem. 270:26897-26903(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NIEHS SNPs program;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP SUBCELLULAR LOCATION, MYRISTOYLATION AT GLY-2, AND MUTAGENESIS OF GLY-2.
RX PubMed=18507738; DOI=10.1111/j.1471-4159.2008.05500.x;
RA Asada A., Yamamoto N., Gohda M., Saito T., Hayashi N., Hisanaga S.;
RT "Myristoylation of p39 and p35 is a determinant of cytoplasmic or nuclear
RT localization of active cyclin-dependent kinase 5 complexes.";
RL J. Neurochem. 106:1325-1336(2008).
CC -!- FUNCTION: Activator of CDK5/TPKII.
CC -!- SUBUNIT: Heterodimer of a catalytic subunit and a regulatory subunit.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18507738};
CC Lipid-anchor {ECO:0000269|PubMed:18507738}; Cytoplasmic side
CC {ECO:0000269|PubMed:18507738}.
CC -!- TISSUE SPECIFICITY: Brain and neuron specific.
CC -!- PTM: Myristoylated. The Gly-2-Ala mutant is absent of the cell
CC periphery, suggesting that a proper myristoylation signal is essential
CC for the proper distribution of CDK5R2 (p39).
CC {ECO:0000269|PubMed:18507738}.
CC -!- SIMILARITY: Belongs to the cyclin-dependent kinase 5 activator family.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=NIEHS-SNPs;
CC URL="http://egp.gs.washington.edu/data/cdk5r2/";
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DR EMBL; U34051; AAC50278.1; -; mRNA.
DR EMBL; DQ307839; ABB96255.1; -; Genomic_DNA.
DR EMBL; AC097468; AAX88916.1; -; Genomic_DNA.
DR CCDS; CCDS2427.1; -.
DR PIR; I39172; I39172.
DR RefSeq; NP_003927.1; NM_003936.4.
DR AlphaFoldDB; Q13319; -.
DR SMR; Q13319; -.
DR BioGRID; 114453; 2.
DR ComplexPortal; CPX-3141; Cyclin-dependent protein kinase 5 holoenzyme complex, p39 variant.
DR MINT; Q13319; -.
DR STRING; 9606.ENSP00000304250; -.
DR iPTMnet; Q13319; -.
DR PhosphoSitePlus; Q13319; -.
DR BioMuta; CDK5R2; -.
DR MassIVE; Q13319; -.
DR PaxDb; Q13319; -.
DR PeptideAtlas; Q13319; -.
DR PRIDE; Q13319; -.
DR ProteomicsDB; 59306; -.
DR Antibodypedia; 34293; 163 antibodies from 26 providers.
DR DNASU; 8941; -.
DR Ensembl; ENST00000302625.6; ENSP00000304250.4; ENSG00000171450.6.
DR GeneID; 8941; -.
DR KEGG; hsa:8941; -.
DR MANE-Select; ENST00000302625.6; ENSP00000304250.4; NM_003936.5; NP_003927.1.
DR UCSC; uc002vjf.5; human.
DR CTD; 8941; -.
DR DisGeNET; 8941; -.
DR GeneCards; CDK5R2; -.
DR HGNC; HGNC:1776; CDK5R2.
DR HPA; ENSG00000171450; Group enriched (brain, pituitary gland, retina).
DR MIM; 603764; gene.
DR neXtProt; NX_Q13319; -.
DR OpenTargets; ENSG00000171450; -.
DR PharmGKB; PA26312; -.
DR VEuPathDB; HostDB:ENSG00000171450; -.
DR eggNOG; KOG3932; Eukaryota.
DR GeneTree; ENSGT00390000008812; -.
DR HOGENOM; CLU_034132_2_1_1; -.
DR InParanoid; Q13319; -.
DR OMA; FVYLLCQ; -.
DR OrthoDB; 1492547at2759; -.
DR PhylomeDB; Q13319; -.
DR TreeFam; TF101036; -.
DR PathwayCommons; Q13319; -.
DR Reactome; R-HSA-9031628; NGF-stimulated transcription.
DR SignaLink; Q13319; -.
DR BioGRID-ORCS; 8941; 9 hits in 1078 CRISPR screens.
DR ChiTaRS; CDK5R2; human.
DR GeneWiki; CDK5R2; -.
DR GenomeRNAi; 8941; -.
DR Pharos; Q13319; Tbio.
DR PRO; PR:Q13319; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q13319; protein.
DR Bgee; ENSG00000171450; Expressed in prefrontal cortex and 102 other tissues.
DR Genevisible; Q13319; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:ARUK-UCL.
DR GO; GO:0030426; C:growth cone; ISS:ARUK-UCL.
DR GO; GO:0016020; C:membrane; ISS:ARUK-UCL.
DR GO; GO:0043005; C:neuron projection; ISS:ARUK-UCL.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016533; C:protein kinase 5 complex; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; ISS:ARUK-UCL.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; ISS:ARUK-UCL.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0021549; P:cerebellum development; IEA:Ensembl.
DR GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR GO; GO:0021819; P:layer formation in cerebral cortex; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; TAS:ProtInc.
DR GO; GO:0021722; P:superior olivary nucleus maturation; IEA:Ensembl.
DR InterPro; IPR004944; CDK5_activator.
DR InterPro; IPR036915; Cyclin-like_sf.
DR PANTHER; PTHR23401; PTHR23401; 1.
DR Pfam; PF03261; CDK5_activator; 1.
DR PIRSF; PIRSF009324; Cdk5_activator; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Lipid-binding; Lipoprotein; Membrane; Myristate;
KW Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:18507738"
FT PROPEP 2..?
FT /evidence="ECO:0000255"
FT /id="PRO_0000004800"
FT CHAIN ?..367
FT /note="Cyclin-dependent kinase 5 activator 2"
FT /id="PRO_0000004801"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..170
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 84
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:O35926"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000269|PubMed:18507738"
FT MUTAGEN 2
FT /note="G->A: Absent from the cell periphery."
FT /evidence="ECO:0000269|PubMed:18507738"
SQ SEQUENCE 367 AA; 38705 MW; D8CBB7C8E0AA8200 CRC64;
MGTVLSLSPA SSAKGRRPGG LPEEKKKAPP AGDEALGGYG APPVGKGGKG ESRLKRPSVL
ISALTWKRLV AASAKKKKGS KKVTPKPAST GPDPLVQQRN RENLLRKGRD PPDGGGTAKP
LAVPVPTVPA AAATCEPPSG GSAAAQPPGS GGGKPPPPPP PAPQVAPPVP GGSPRRVIVQ
ASTGELLRCL GDFVCRRCYR LKELSPGELV GWFRGVDRSL LLQGWQDQAF ITPANLVFVY
LLCRESLRGD ELASAAELQA AFLTCLYLAY SYMGNEISYP LKPFLVEPDK ERFWQRCLRL
IQRLSPQMLR LNADPHFFTQ VFQDLKNEGE AAASGGGPPS GGAPAASSAA RDSCAAGTKH
WTMNLDR
