CD5R2_MOUSE
ID CD5R2_MOUSE Reviewed; 369 AA.
AC O35926; O35277; Q9QYD1;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Cyclin-dependent kinase 5 activator 2;
DE Short=CDK5 activator 2;
DE AltName: Full=Cyclin-dependent kinase 5 regulatory subunit 2;
DE AltName: Full=p39;
DE AltName: Full=p39I;
DE Flags: Precursor;
GN Name=Cdk5r2; Synonyms=Nck5ai;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9655938; DOI=10.1016/s0167-4781(98)00073-6;
RA Nilden F., Baeckstroem A., Bark C.;
RT "Molecular cloning and characterisation of a mouse gene encoding an isoform
RT of the neuronal cyclin-dependent kinase 5 (CDK5) activator.";
RL Biochim. Biophys. Acta 1398:371-376(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RA Zheng M., Leung C.L., Liem R.K.H.;
RT "Comparative analysis of gene expression of the cyclin-dependent kinase 5
RT (cdk5) activators p35 and p39 in the rat CNS and embryonic development
RT revealed distinctive overlap with cdk5.";
RL Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ;
RA Treuner M., Qi Z., Zhu X., Wang J.H.;
RT "Characterization of the mouse gene encoding p39, an isoform of neuronal
RT cdk5 activator.";
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-84, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Activator of CDK5/TPKII.
CC -!- SUBUNIT: Heterodimer of a catalytic subunit and a regulatory subunit.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor
CC {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC -!- PTM: Myristoylated. The Gly-2-Ala mutant is absent of the cell
CC periphery, suggesting that a proper myristoylation signal is essential
CC for the proper distribution of CDK5R2 (p39) (By similarity).
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cyclin-dependent kinase 5 activator family.
CC {ECO:0000305}.
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DR EMBL; U90267; AAC53595.1; -; Genomic_DNA.
DR EMBL; AF016393; AAB69709.1; -; Genomic_DNA.
DR EMBL; AF071086; AAF14854.1; -; Genomic_DNA.
DR EMBL; CH466548; EDL00353.1; -; Genomic_DNA.
DR CCDS; CCDS48290.1; -.
DR RefSeq; NP_034002.2; NM_009872.3.
DR AlphaFoldDB; O35926; -.
DR SMR; O35926; -.
DR ComplexPortal; CPX-3145; Cyclin-dependent protein kinase 5 holoenzyme complex, p39 variant.
DR MINT; O35926; -.
DR STRING; 10090.ENSMUSP00000125322; -.
DR iPTMnet; O35926; -.
DR PhosphoSitePlus; O35926; -.
DR MaxQB; O35926; -.
DR PaxDb; O35926; -.
DR PeptideAtlas; O35926; -.
DR PRIDE; O35926; -.
DR ProteomicsDB; 279986; -.
DR Antibodypedia; 34293; 163 antibodies from 26 providers.
DR DNASU; 12570; -.
DR Ensembl; ENSMUST00000160379; ENSMUSP00000125322; ENSMUSG00000090071.
DR GeneID; 12570; -.
DR KEGG; mmu:12570; -.
DR UCSC; uc007bng.2; mouse.
DR CTD; 8941; -.
DR MGI; MGI:1330828; Cdk5r2.
DR VEuPathDB; HostDB:ENSMUSG00000090071; -.
DR eggNOG; KOG3932; Eukaryota.
DR GeneTree; ENSGT00390000008812; -.
DR HOGENOM; CLU_034132_2_1_1; -.
DR InParanoid; O35926; -.
DR OMA; FVYLLCQ; -.
DR OrthoDB; 1492547at2759; -.
DR PhylomeDB; O35926; -.
DR TreeFam; TF101036; -.
DR BioGRID-ORCS; 12570; 6 hits in 76 CRISPR screens.
DR PRO; PR:O35926; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; O35926; protein.
DR Bgee; ENSMUSG00000090071; Expressed in superior frontal gyrus and 72 other tissues.
DR Genevisible; O35926; MM.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IC:ComplexPortal.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR GO; GO:0030426; C:growth cone; ISO:MGI.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0043005; C:neuron projection; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016533; C:protein kinase 5 complex; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IPI:ARUK-UCL.
DR GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IDA:ARUK-UCL.
DR GO; GO:0008092; F:cytoskeletal protein binding; TAS:MGI.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0021549; P:cerebellum development; IGI:MGI.
DR GO; GO:0021766; P:hippocampus development; IGI:MGI.
DR GO; GO:0021819; P:layer formation in cerebral cortex; IGI:MGI.
DR GO; GO:0001764; P:neuron migration; IGI:MGI.
DR GO; GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IDA:MGI.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; IGI:MGI.
DR GO; GO:0021722; P:superior olivary nucleus maturation; IGI:MGI.
DR InterPro; IPR004944; CDK5_activator.
DR InterPro; IPR036915; Cyclin-like_sf.
DR PANTHER; PTHR23401; PTHR23401; 1.
DR Pfam; PF03261; CDK5_activator; 1.
DR PIRSF; PIRSF009324; Cdk5_activator; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Lipid-binding; Lipoprotein; Membrane; Myristate;
KW Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT PROPEP 2..?
FT /evidence="ECO:0000255"
FT /id="PRO_0000004802"
FT CHAIN ?..369
FT /note="Cyclin-dependent kinase 5 activator 2"
FT /id="PRO_0000004803"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..170
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 84
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000250"
FT CONFLICT 91
FT /note="G -> V (in Ref. 2; AAB69709)"
FT /evidence="ECO:0000305"
FT CONFLICT 172
FT /note="G -> S (in Ref. 1; AAC53595)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="G -> R (in Ref. 1; AAC53595)"
FT /evidence="ECO:0000305"
FT CONFLICT 197
FT /note="R -> S (in Ref. 1; AAC53595)"
FT /evidence="ECO:0000305"
FT CONFLICT 220
FT /note="L -> W (in Ref. 2; AAB69709)"
FT /evidence="ECO:0000305"
FT CONFLICT 248
FT /note="R -> S (in Ref. 1; AAC53595)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="A -> G (in Ref. 2; AAB69709)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 369 AA; 38924 MW; D426300E88441D99 CRC64;
MGTVLSLSPA SSAKGRRPGG LPEEKKKAPP AGDEALGGYG APPAGKGGKG ESRLKRPSVL
ISALTWKRLV AASAKKKKGS KKVTPKPAST GPDPLVQQRN RENLLRKGRD GPDGGGTAKP
LAVPVPTVPT TAATCEPPSG GSAAAPPPGS GGGKPPPPPP PAPQAAPPAP GGSPRRVIVQ
ASTGELLRCL GDFVCRRCYR LKELSPGELV GWFRGVDRSL LLQGWQDQAF ITPANLVFVY
LLCRESLRGD ELASAAELQA AFLTCLYLAY SYMGNEISYP LKPFLVEPDK ERFWQRCLRL
IQRLSPQMLR LNADPHFFTQ VFQDLKNEGE AAASTGGPPS GSSASTTSSS SARDSCATGA
KHWTMNLDR
