CD68_HUMAN
ID CD68_HUMAN Reviewed; 354 AA.
AC P34810; B4DVT4; Q53HR6; Q53XI3; Q96BI7;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 15-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 184.
DE RecName: Full=Macrosialin;
DE AltName: Full=Gp110;
DE AltName: CD_antigen=CD68;
DE Flags: Precursor;
GN Name=CD68;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT), AND VARIANT LYS-254.
RX PubMed=7680921;
RA Holness C.L., Simmons D.L.;
RT "Molecular cloning of CD68, a human macrophage marker related to lysosomal
RT glycoproteins.";
RL Blood 81:1607-1613(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND 3).
RC TISSUE=Spleen, and Umbilical cord blood;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
RC TISSUE=Adipose tissue;
RA Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y.,
RA Tanaka A., Yokoyama S.;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28.
RX PubMed=9790779; DOI=10.1006/geno.1998.5515;
RA Jones E., Quinn C.M., See C.G., Montgomery D.S., Ford M.J., Koelble K.,
RA Gordon S., Greaves D.R.;
RT "The linked human elongation initiation factor 4A1 (EIF4A1) and CD68 genes
RT map to chromosome 17p13.";
RL Genomics 53:248-250(1998).
RN [9]
RP USE AS A MACROPHAGE MARKER.
RX PubMed=15194571; DOI=10.1136/ard.2003.013029;
RA Kunisch E., Fuhrmann R., Roth A., Winter R., Lungershausen W., Kinne R.W.;
RT "Macrophage specificity of three anti-CD68 monoclonal antibodies (KP1,
RT EBM11, and PGM1) widely used for immunohistochemistry and flow cytometry.";
RL Ann. Rheum. Dis. 63:774-784(2004).
RN [10]
RP USE AS A MACROPHAGE MARKER.
RX PubMed=15647451;
RA Beranek J.T.;
RT "CD68 is not a macrophage-specific antigen.";
RL Ann. Rheum. Dis. 64:342-343(2005).
RN [11]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-261.
RC TISSUE=Platelet;
RX PubMed=16263699; DOI=10.1074/mcp.m500324-mcp200;
RA Lewandrowski U., Moebius J., Walter U., Sickmann A.;
RT "Elucidation of N-glycosylation sites on human platelet proteins: a
RT glycoproteomic approach.";
RL Mol. Cell. Proteomics 5:226-233(2006).
RN [12]
RP TISSUE SPECIFICITY.
RX PubMed=18405323; DOI=10.1111/j.1365-3083.2008.02091.x;
RA Gottfried E., Kunz-Schughart L.A., Weber A., Rehli M., Peuker A.,
RA Muller A., Kastenberger M., Brockhoff G., Andreesen R., Kreutz M.;
RT "Expression of CD68 in non-myeloid cell types.";
RL Scand. J. Immunol. 67:453-463(2008).
RN [13]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-199; ASN-261 AND ASN-279.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of multiple
RT enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [14]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: Could play a role in phagocytic activities of tissue
CC macrophages, both in intracellular lysosomal metabolism and
CC extracellular cell-cell and cell-pathogen interactions. Binds to
CC tissue- and organ-specific lectins or selectins, allowing homing of
CC macrophage subsets to particular sites. Rapid recirculation of CD68
CC from endosomes and lysosomes to the plasma membrane may allow
CC macrophages to crawl over selectin-bearing substrates or other cells.
CC -!- INTERACTION:
CC P34810; O95994: AGR2; NbExp=3; IntAct=EBI-2826276, EBI-712648;
CC P34810; Q13520: AQP6; NbExp=3; IntAct=EBI-2826276, EBI-13059134;
CC P34810; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-2826276, EBI-11749983;
CC P34810; Q86UP2-3: KTN1; NbExp=3; IntAct=EBI-2826276, EBI-12007212;
CC P34810; Q969L2: MAL2; NbExp=3; IntAct=EBI-2826276, EBI-944295;
CC P34810; P15941-11: MUC1; NbExp=3; IntAct=EBI-2826276, EBI-17263240;
CC P34810; Q96CS7: PLEKHB2; NbExp=3; IntAct=EBI-2826276, EBI-373552;
CC P34810; Q96EQ0: SGTB; NbExp=3; IntAct=EBI-2826276, EBI-744081;
CC P34810; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-2826276, EBI-11724423;
CC P34810; Q96B49: TOMM6; NbExp=6; IntAct=EBI-2826276, EBI-10826510;
CC -!- SUBCELLULAR LOCATION: [Isoform Short]: Cell membrane; Single-pass type
CC I membrane protein.
CC -!- SUBCELLULAR LOCATION: [Isoform Long]: Endosome membrane; Single-pass
CC type I membrane protein. Lysosome membrane; Single-pass type I membrane
CC protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=Long; Synonyms=CD68.1;
CC IsoId=P34810-1; Sequence=Displayed;
CC Name=Short; Synonyms=CD68.2;
CC IsoId=P34810-2; Sequence=VSP_003041, VSP_003042;
CC Name=3;
CC IsoId=P34810-3; Sequence=VSP_003041;
CC -!- TISSUE SPECIFICITY: Highly expressed by blood monocytes and tissue
CC macrophages. Also expressed in lymphocytes, fibroblasts and endothelial
CC cells. Expressed in many tumor cell lines which could allow them to
CC attach to selectins on vascular endothelium, facilitating their
CC dissemination to secondary sites. {ECO:0000269|PubMed:18405323}.
CC -!- PTM: N- and O-glycosylated. {ECO:0000269|PubMed:16263699,
CC ECO:0000269|PubMed:19159218}.
CC -!- SIMILARITY: Belongs to the LAMP family. {ECO:0000255|PROSITE-
CC ProRule:PRU00740}.
CC -!- CAUTION: CD68 is a commonly used marker for macrophages. However, a
CC number of studies (PubMed:15194571, PubMed:15647451 and
CC PubMed:18405323) have shown that CD68 antibodies react with other
CC hematopoietic and non-hematopoietic cell types, suggesting that CD68
CC may not be a macrophage-specific antigen. {ECO:0000305}.
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DR EMBL; S57235; AAB25811.1; -; mRNA.
DR EMBL; BT009923; AAP88925.1; -; mRNA.
DR EMBL; AK290238; BAF82927.1; -; mRNA.
DR EMBL; AK222492; BAD96212.1; -; mRNA.
DR EMBL; AK222514; BAD96234.1; -; mRNA.
DR EMBL; AK301223; BAG62796.1; -; mRNA.
DR EMBL; AC016876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471108; EAW90165.1; -; Genomic_DNA.
DR EMBL; BC015557; AAH15557.1; -; mRNA.
DR EMBL; AF060540; AAC70006.1; -; Genomic_DNA.
DR CCDS; CCDS11114.1; -. [P34810-1]
DR CCDS; CCDS58512.1; -. [P34810-3]
DR PIR; A48931; A48931.
DR RefSeq; NP_001035148.1; NM_001040059.1. [P34810-3]
DR RefSeq; NP_001242.2; NM_001251.2. [P34810-1]
DR AlphaFoldDB; P34810; -.
DR SMR; P34810; -.
DR BioGRID; 107406; 29.
DR IntAct; P34810; 22.
DR STRING; 9606.ENSP00000250092; -.
DR GlyConnect; 1483; 17 N-Linked glycans (2 sites).
DR GlyGen; P34810; 11 sites, 16 N-linked glycans (2 sites), 2 O-linked glycans (2 sites).
DR iPTMnet; P34810; -.
DR PhosphoSitePlus; P34810; -.
DR BioMuta; CD68; -.
DR DMDM; 147744552; -.
DR EPD; P34810; -.
DR jPOST; P34810; -.
DR MassIVE; P34810; -.
DR MaxQB; P34810; -.
DR PaxDb; P34810; -.
DR PeptideAtlas; P34810; -.
DR PRIDE; P34810; -.
DR ProteomicsDB; 54942; -. [P34810-1]
DR ProteomicsDB; 54943; -. [P34810-2]
DR Antibodypedia; 3511; 2422 antibodies from 55 providers.
DR DNASU; 968; -.
DR Ensembl; ENST00000250092.11; ENSP00000250092.6; ENSG00000129226.14. [P34810-1]
DR Ensembl; ENST00000380498.10; ENSP00000369867.6; ENSG00000129226.14. [P34810-3]
DR GeneID; 968; -.
DR KEGG; hsa:968; -.
DR MANE-Select; ENST00000250092.11; ENSP00000250092.6; NM_001251.3; NP_001242.2.
DR UCSC; uc002ghu.4; human. [P34810-1]
DR CTD; 968; -.
DR DisGeNET; 968; -.
DR GeneCards; CD68; -.
DR HGNC; HGNC:1693; CD68.
DR HPA; ENSG00000129226; Tissue enhanced (lung, lymphoid tissue).
DR MIM; 153634; gene.
DR neXtProt; NX_P34810; -.
DR OpenTargets; ENSG00000129226; -.
DR PharmGKB; PA26232; -.
DR VEuPathDB; HostDB:ENSG00000129226; -.
DR eggNOG; KOG4818; Eukaryota.
DR GeneTree; ENSGT00950000182899; -.
DR HOGENOM; CLU_071610_0_0_1; -.
DR InParanoid; P34810; -.
DR OMA; PNKTKAQ; -.
DR OrthoDB; 1321296at2759; -.
DR PhylomeDB; P34810; -.
DR TreeFam; TF316339; -.
DR PathwayCommons; P34810; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; P34810; -.
DR SIGNOR; P34810; -.
DR BioGRID-ORCS; 968; 9 hits in 1076 CRISPR screens.
DR ChiTaRS; CD68; human.
DR GenomeRNAi; 968; -.
DR Pharos; P34810; Tbio.
DR PRO; PR:P34810; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P34810; protein.
DR Bgee; ENSG00000129226; Expressed in leukocyte and 103 other tissues.
DR ExpressionAtlas; P34810; baseline and differential.
DR GO; GO:0035577; C:azurophil granule membrane; TAS:Reactome.
DR GO; GO:0016021; C:integral component of membrane; TAS:ProtInc.
DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005764; C:lysosome; ISS:ARUK-UCL.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; IDA:ARUK-UCL.
DR GO; GO:0007568; P:aging; ISS:ARUK-UCL.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; ISS:ARUK-UCL.
DR GO; GO:0031669; P:cellular response to nutrient levels; ISS:ARUK-UCL.
DR GO; GO:0140052; P:cellular response to oxidised low-density lipoprotein particle stimulus; ISS:ARUK-UCL.
DR GO; GO:0072594; P:establishment of protein localization to organelle; IBA:GO_Central.
DR GO; GO:0002437; P:inflammatory response to antigenic stimulus; ISS:ARUK-UCL.
DR GO; GO:0002605; P:negative regulation of dendritic cell antigen processing and presentation; ISS:ARUK-UCL.
DR InterPro; IPR018134; LAMP_CS.
DR InterPro; IPR002000; Lysosome-assoc_membr_glycop.
DR PANTHER; PTHR11506; PTHR11506; 2.
DR Pfam; PF01299; Lamp; 1.
DR PRINTS; PR00336; LYSASSOCTDMP.
DR PROSITE; PS00311; LAMP_2; 1.
DR PROSITE; PS51407; LAMP_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; Disulfide bond; Endosome;
KW Glycoprotein; Lysosome; Membrane; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..354
FT /note="Macrosialin"
FT /id="PRO_0000017102"
FT TOPO_DOM 22..319
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..344
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00740"
FT TOPO_DOM 345..354
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00740"
FT REPEAT 70..99
FT /note="1"
FT REPEAT 100..129
FT /note="2"
FT REGION 23..140
FT /note="Mucin-like"
FT REGION 40..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..129
FT /note="2 X 30 AA tandem repeats"
FT COMPBIAS 40..136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..151
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 118
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 199
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19159218"
FT CARBOHYD 246
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:16263699,
FT ECO:0000269|PubMed:19159218"
FT CARBOHYD 279
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19159218"
FT DISULFID 169..207
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00740"
FT DISULFID 277..314
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00740"
FT VAR_SEQ 17..43
FT /note="Missing (in isoform Short and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:7680921"
FT /id="VSP_003041"
FT VAR_SEQ 83..112
FT /note="Missing (in isoform Short)"
FT /evidence="ECO:0000303|PubMed:7680921"
FT /id="VSP_003042"
FT VARIANT 254
FT /note="Q -> K (in dbSNP:rs9901673)"
FT /evidence="ECO:0000269|PubMed:7680921"
FT /id="VAR_016144"
FT VARIANT 329
FT /note="I -> T (in dbSNP:rs35452170)"
FT /id="VAR_049725"
FT VARIANT 340
FT /note="A -> T (in dbSNP:rs17607)"
FT /id="VAR_016145"
FT VARIANT 350
FT /note="A -> T (in dbSNP:rs9901675)"
FT /id="VAR_049726"
FT CONFLICT 95
FT /note="S -> G (in Ref. 4; BAD96234)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 354 AA; 37408 MW; 69E68D69EDE8EFB0 CRC64;
MRLAVLFSGA LLGLLAAQGT GNDCPHKKSA TLLPSFTVTP TVTESTGTTS HRTTKSHKTT
THRTTTTGTT SHGPTTATHN PTTTSHGNVT VHPTSNSTAT SQGPSTATHS PATTSHGNAT
VHPTSNSTAT SPGFTSSAHP EPPPPSPSPS PTSKETIGDY TWTNGSQPCV HLQAQIQIRV
MYTTQGGGEA WGISVLNPNK TKVQGSCEGA HPHLLLSFPY GHLSFGFMQD LQQKVVYLSY
MAVEYNVSFP HAAQWTFSAQ NASLRDLQAP LGQSFSCSNS SIILSPAVHL DLLSLRLQAA
QLPHTGVFGQ SFSCPSDRSI LLPLIIGLIL LGLLALVLIA FCIIRRRPSA YQAL
