CD69_MOUSE
ID CD69_MOUSE Reviewed; 199 AA.
AC P37217;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Early activation antigen CD69;
DE AltName: CD_antigen=CD69;
GN Name=Cd69;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8100776; DOI=10.1002/eji.1830230737;
RA Ziegler S.F., Ramsdell F., Hjerrild K.A., Armitage R.J., Grabstein K.H.,
RA Hennen K.B., Farrah T., Fanslow W.C., Shevach E.M., Alderson M.R.;
RT "Molecular characterization of the early activation antigen CD69: a type II
RT membrane glycoprotein related to a family of natural killer cell activation
RT antigens.";
RL Eur. J. Immunol. 23:1643-1648(1993).
CC -!- FUNCTION: Involved in lymphocyte proliferation and functions as a
CC signal transmitting receptor in lymphocytes, natural killer (NK) cells,
CC and platelets.
CC -!- SUBUNIT: Homodimer; disulfide-linked.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed on the surface of activated T-cells, B-
CC cells, natural killer cells, neutrophils and platelets.
CC -!- DEVELOPMENTAL STAGE: Earliest inducible cell surface glycoprotein
CC acquired during lymphoid activation.
CC -!- INDUCTION: By the activation of T-lymphocytes.
CC -!- PTM: Constitutive Ser/Thr phosphorylation in both mature thymocytes and
CC activated T-lymphocytes. {ECO:0000250}.
CC -!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
CC Note=CD69;
CC URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_mou_Ctlect_173";
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DR EMBL; L23638; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS20582.1; -.
DR RefSeq; NP_001028294.1; NM_001033122.3.
DR AlphaFoldDB; P37217; -.
DR SMR; P37217; -.
DR DIP; DIP-60425N; -.
DR IntAct; P37217; 1.
DR STRING; 10090.ENSMUSP00000032259; -.
DR GlyGen; P37217; 3 sites.
DR iPTMnet; P37217; -.
DR PhosphoSitePlus; P37217; -.
DR EPD; P37217; -.
DR jPOST; P37217; -.
DR PaxDb; P37217; -.
DR PRIDE; P37217; -.
DR ProteomicsDB; 279987; -.
DR Antibodypedia; 3741; 1229 antibodies from 47 providers.
DR DNASU; 12515; -.
DR Ensembl; ENSMUST00000032259; ENSMUSP00000032259; ENSMUSG00000030156.
DR GeneID; 12515; -.
DR KEGG; mmu:12515; -.
DR UCSC; uc009efi.1; mouse.
DR CTD; 969; -.
DR MGI; MGI:88343; Cd69.
DR VEuPathDB; HostDB:ENSMUSG00000030156; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00940000161987; -.
DR HOGENOM; CLU_049894_8_4_1; -.
DR InParanoid; P37217; -.
DR OMA; WFNFTGS; -.
DR OrthoDB; 1289964at2759; -.
DR PhylomeDB; P37217; -.
DR TreeFam; TF351467; -.
DR BioGRID-ORCS; 12515; 2 hits in 73 CRISPR screens.
DR PRO; PR:P37217; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P37217; protein.
DR Bgee; ENSMUSG00000030156; Expressed in peripheral lymph node and 51 other tissues.
DR ExpressionAtlas; P37217; baseline and differential.
DR Genevisible; P37217; MM.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0005509; F:calcium ion binding; ISO:MGI.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEP:UniProtKB.
DR CDD; cd03593; CLECT_NK_receptors_like; 1.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR033992; NKR-like_CTLD.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Lectin; Membrane; Phosphoprotein;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..199
FT /note="Early activation antigen CD69"
FT /id="PRO_0000046584"
FT TOPO_DOM 1..40
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 92..195
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 150
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 68
FT /note="Interchain"
FT /evidence="ECO:0000305"
FT DISULFID 85..96
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 113..194
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 173..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
SQ SEQUENCE 199 AA; 22517 MW; 39F8E4941D36D4F6 CRC64;
MDSENCSITE NSSSHLERGQ KDHGTSIHFE KHHEGSIQVS IPWAVLIVVL ITSLIIALIA
LNVGKYNCPG LYEKLESSDH HVATCKNEWI SYKRTCYFFS TTTKSWALAQ RSCSEDAATL
AVIDSEKDMT FLKRYSGELE HWIGLKNEAN QTWKWANGKE FNSWFNLTGS GRCVSVNHKN
VTAVDCEANF HWVCSKPSR
