CD70_MOUSE
ID CD70_MOUSE Reviewed; 195 AA.
AC O55237;
DT 06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=CD70 antigen;
DE AltName: Full=CD27 ligand;
DE Short=CD27-L;
DE AltName: Full=Tumor necrosis factor ligand superfamily member 7;
DE AltName: CD_antigen=CD70;
GN Name=Cd70; Synonyms=Cd27l, Cd27lg, Tnfsf7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=129/SvJ; TISSUE=B-cell lymphoma;
RX PubMed=9366422;
RA Tesselaar K., Gravestein L.A., van Schijndel G.M.W., Borst J.,
RA van Lier R.A.W.;
RT "Characterization of murine CD70, the ligand of the TNF receptor family
RT member CD27.";
RL J. Immunol. 159:4959-4965(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=BALB/cJ; TISSUE=B-cell lymphoma;
RX PubMed=9620608; DOI=10.1093/intimm/10.4.517;
RA Oshima H., Nakano H., Nohara C., Kobata T., Nakajima A., Jenkins N.A.,
RA Gilbert D.J., Copeland N.G., Muto T., Yagita H., Okumura K.;
RT "Characterization of murine CD70 by molecular cloning and mAb.";
RL Int. Immunol. 10:517-526(1998).
CC -!- FUNCTION: Cytokine which is the ligand for CD27. The CD70-CD27 pathway
CC plays an important role in the generation and maintenance of T cell
CC immunity, in particular during antiviral responses. Upon CD27 binding,
CC induces the proliferation of costimulated T-cells and enhances the
CC generation of cytolytic T-cells. {ECO:0000269|PubMed:9620608}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P32970}; Single-
CC pass type II membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Very low level of expression. Detected in
CC splenocytes and thymocytes.
CC -!- INDUCTION: By IL-2 and concanavalin A (Con A).
CC -!- PTM: N-glycosylated.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; Y13637; CAA73977.1; -; Genomic_DNA.
DR EMBL; Y13638; CAA73977.1; JOINED; Genomic_DNA.
DR EMBL; Y13636; CAA73976.1; -; mRNA.
DR EMBL; U78091; AAD00274.1; -; mRNA.
DR CCDS; CCDS28927.1; -.
DR RefSeq; NP_035747.1; NM_011617.2.
DR AlphaFoldDB; O55237; -.
DR SMR; O55237; -.
DR STRING; 10090.ENSMUSP00000019633; -.
DR GlyGen; O55237; 3 sites.
DR PhosphoSitePlus; O55237; -.
DR PaxDb; O55237; -.
DR PRIDE; O55237; -.
DR ProteomicsDB; 283752; -.
DR Antibodypedia; 24212; 860 antibodies from 40 providers.
DR DNASU; 21948; -.
DR Ensembl; ENSMUST00000019633; ENSMUSP00000019633; ENSMUSG00000019489.
DR GeneID; 21948; -.
DR KEGG; mmu:21948; -.
DR UCSC; uc008dee.1; mouse.
DR CTD; 970; -.
DR MGI; MGI:1195273; Cd70.
DR VEuPathDB; HostDB:ENSMUSG00000019489; -.
DR eggNOG; ENOG502TEKD; Eukaryota.
DR GeneTree; ENSGT00390000006744; -.
DR HOGENOM; CLU_114585_0_0_1; -.
DR InParanoid; O55237; -.
DR OMA; FGIQWVH; -.
DR OrthoDB; 1236901at2759; -.
DR PhylomeDB; O55237; -.
DR TreeFam; TF338269; -.
DR Reactome; R-MMU-5669034; TNFs bind their physiological receptors.
DR BioGRID-ORCS; 21948; 3 hits in 77 CRISPR screens.
DR PRO; PR:O55237; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; O55237; protein.
DR Bgee; ENSMUSG00000019489; Expressed in Meckel's cartilage and 18 other tissues.
DR ExpressionAtlas; O55237; baseline and differential.
DR Genevisible; O55237; MM.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0005125; F:cytokine activity; ISS:UniProtKB.
DR GO; GO:0002020; F:protease binding; ISO:MGI.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0019724; P:B cell mediated immunity; ISS:UniProtKB.
DR GO; GO:0042100; P:B cell proliferation; ISS:UniProtKB.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISO:MGI.
DR GO; GO:0002456; P:T cell mediated immunity; ISS:UniProtKB.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR042374; CD70.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15152; PTHR15152; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..195
FT /note="CD70 antigen"
FT /id="PRO_0000185498"
FT TOPO_DOM 1..23
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 24..44
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 45..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 65
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 116
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 172
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 135..153
FT /evidence="ECO:0000255"
SQ SEQUENCE 195 AA; 21919 MW; BD14671A2C8E26C7 CRC64;
MPEEGRPCPW VRWSGTAFQR QWPWLLLVVF ITVFCCWFHC SGLLSKQQQR LLEHPEPHTA
ELQLNLTVPR KDPTLRWGAG PALGRSFTHG PELEEGHLRI HQDGLYRLHI QVTLANCSSP
GSTLQHRATL AVGICSPAAH GISLLRGRFG QDCTVALQRL TYLVHGDVLC TNLTLPLLPS
RNADETFFGV QWICP
