CD70_PIG
ID CD70_PIG Reviewed; 190 AA.
AC Q3ZDR4;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=CD70 antigen;
DE AltName: Full=CD27 ligand;
DE Short=CD27-L;
DE AltName: Full=Tumor necrosis factor ligand superfamily member 7;
DE AltName: CD_antigen=CD70;
GN Name=CD70; Synonyms=CD27L, TNFSF7;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kang J.-H., Jeon D.-H., Cho J.-J., Lee D.-S., Lee J.-R., Hwang W.-S.,
RA Lee G.;
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cytokine which is the ligand for CD27. The CD70-CD27 pathway
CC plays an important role in the generation and maintenance of T cell
CC immunity, in particular during antiviral responses. Upon CD27 binding,
CC induces the proliferation of costimulated T-cells and enhances the
CC generation of cytolytic T-cells. {ECO:0000250|UniProtKB:P32970}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P32970}; Single-
CC pass type II membrane protein {ECO:0000255}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
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DR EMBL; AY949027; AAY24694.1; -; mRNA.
DR RefSeq; NP_001037996.1; NM_001044531.1.
DR AlphaFoldDB; Q3ZDR4; -.
DR SMR; Q3ZDR4; -.
DR STRING; 9823.ENSSSCP00000023818; -.
DR PaxDb; Q3ZDR4; -.
DR PRIDE; Q3ZDR4; -.
DR GeneID; 733577; -.
DR KEGG; ssc:733577; -.
DR CTD; 970; -.
DR eggNOG; ENOG502TEKD; Eukaryota.
DR HOGENOM; CLU_114585_0_0_1; -.
DR InParanoid; Q3ZDR4; -.
DR OMA; FGIQWVH; -.
DR OrthoDB; 1236901at2759; -.
DR TreeFam; TF338269; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR042374; CD70.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR15152; PTHR15152; 1.
DR Pfam; PF00229; TNF; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; SSF49842; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Membrane; Reference proteome;
KW Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..190
FT /note="CD70 antigen"
FT /id="PRO_0000286000"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 18..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT CARBOHYD 59
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 130..148
FT /evidence="ECO:0000255"
SQ SEQUENCE 190 AA; 21275 MW; 092916C9A275E691 CRC64;
MEEEGSGCNV PRLPWASILR AALLLLLIGM VIYCFLCGQR FTQQQLDSTG WDLAELLLNH
TESRQDPRLR WQGSPALGRS FVHGPELDNG QLRIQRTGIY RLHIQVTLTN CSSSTWTVMP
RQATLTLGIC SPTTHSISLL RLNFHHTCRV ASQRLTPLAK GDVLCTNLTL PLLPSRNADE
TFFGVQLVRP
