CD72_HUMAN
ID CD72_HUMAN Reviewed; 359 AA.
AC P21854;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 03-AUG-2022, entry version 189.
DE RecName: Full=B-cell differentiation antigen CD72;
DE AltName: Full=Lyb-2;
DE AltName: CD_antigen=CD72;
GN Name=CD72;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2141045;
RA von Hoegen I., Nakayama E., Parnes J.R.;
RT "Identification of a human protein homologous to the mouse Lyb-2 B cell
RT differentiation antigen and sequence of the corresponding cDNA.";
RL J. Immunol. 144:4870-4877(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas, and Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in B-cell proliferation and differentiation.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Associates with CD5. Interacts
CC (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC P21854; O75787: ATP6AP2; NbExp=3; IntAct=EBI-307924, EBI-2512037;
CC P21854; Q13323: BIK; NbExp=3; IntAct=EBI-307924, EBI-700794;
CC P21854; Q99675: CGRRF1; NbExp=3; IntAct=EBI-307924, EBI-2130213;
CC P21854; O95471: CLDN7; NbExp=3; IntAct=EBI-307924, EBI-740744;
CC P21854; Q96BA8: CREB3L1; NbExp=5; IntAct=EBI-307924, EBI-6942903;
CC P21854; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-307924, EBI-13345167;
CC P21854; Q8IYS0: GRAMD1C; NbExp=3; IntAct=EBI-307924, EBI-7054335;
CC P21854; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-307924, EBI-2820517;
CC P21854; Q8N386: LRRC25; NbExp=3; IntAct=EBI-307924, EBI-11304917;
CC P21854; Q8N112: LSMEM2; NbExp=3; IntAct=EBI-307924, EBI-10264855;
CC P21854; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-307924, EBI-12806656;
CC P21854; Q9GZW8: MS4A7; NbExp=3; IntAct=EBI-307924, EBI-721391;
CC P21854; Q02297-10: NRG1; NbExp=3; IntAct=EBI-307924, EBI-12842334;
CC P21854; Q9HBV2: SPACA1; NbExp=3; IntAct=EBI-307924, EBI-17498703;
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
CC -!- TISSUE SPECIFICITY: Pre-B-cells and B-cells but not terminally
CC differentiated plasma cells.
CC -!- PTM: Phosphorylated upon engagement of the B-cell receptor, probably by
CC LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with
CC PTPN6/SHP-1 (By similarity). {ECO:0000250}.
CC -!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
CC Note=CD72;
CC URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_237";
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DR EMBL; M54992; AAA36189.1; -; mRNA.
DR EMBL; BC030227; AAH30227.1; -; mRNA.
DR CCDS; CCDS6581.1; -.
DR PIR; A43532; A43532.
DR RefSeq; NP_001773.1; NM_001782.2.
DR AlphaFoldDB; P21854; -.
DR SMR; P21854; -.
DR BioGRID; 107409; 26.
DR IntAct; P21854; 19.
DR STRING; 9606.ENSP00000379980; -.
DR GlyGen; P21854; 1 site.
DR iPTMnet; P21854; -.
DR PhosphoSitePlus; P21854; -.
DR SwissPalm; P21854; -.
DR BioMuta; CD72; -.
DR DMDM; 116029; -.
DR jPOST; P21854; -.
DR MassIVE; P21854; -.
DR PaxDb; P21854; -.
DR PeptideAtlas; P21854; -.
DR PRIDE; P21854; -.
DR ProteomicsDB; 53933; -.
DR ABCD; P21854; 1 sequenced antibody.
DR Antibodypedia; 3742; 594 antibodies from 39 providers.
DR DNASU; 971; -.
DR Ensembl; ENST00000259633.9; ENSP00000259633.4; ENSG00000137101.14.
DR GeneID; 971; -.
DR KEGG; hsa:971; -.
DR MANE-Select; ENST00000259633.9; ENSP00000259633.4; NM_001782.3; NP_001773.1.
DR CTD; 971; -.
DR DisGeNET; 971; -.
DR GeneCards; CD72; -.
DR HGNC; HGNC:1696; CD72.
DR HPA; ENSG00000137101; Tissue enriched (lymphoid).
DR MIM; 107272; gene.
DR neXtProt; NX_P21854; -.
DR OpenTargets; ENSG00000137101; -.
DR PharmGKB; PA26235; -.
DR VEuPathDB; HostDB:ENSG00000137101; -.
DR eggNOG; KOG4297; Eukaryota.
DR GeneTree; ENSGT00390000003668; -.
DR HOGENOM; CLU_066571_0_0_1; -.
DR InParanoid; P21854; -.
DR OMA; TCRLEWN; -.
DR OrthoDB; 987250at2759; -.
DR PhylomeDB; P21854; -.
DR TreeFam; TF337121; -.
DR PathwayCommons; P21854; -.
DR Reactome; R-HSA-416700; Other semaphorin interactions.
DR SignaLink; P21854; -.
DR SIGNOR; P21854; -.
DR BioGRID-ORCS; 971; 13 hits in 1068 CRISPR screens.
DR ChiTaRS; CD72; human.
DR GenomeRNAi; 971; -.
DR Pharos; P21854; Tbio.
DR PRO; PR:P21854; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; P21854; protein.
DR Bgee; ENSG00000137101; Expressed in spleen and 110 other tissues.
DR ExpressionAtlas; P21854; baseline and differential.
DR Genevisible; P21854; HS.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; TAS:ProtInc.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; NAS:UniProtKB.
DR GO; GO:0007155; P:cell adhesion; TAS:ProtInc.
DR Gene3D; 3.10.100.10; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR039689; CD72-like.
DR InterPro; IPR016187; CTDL_fold.
DR PANTHER; PTHR15028; PTHR15028; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR SMART; SM00034; CLECT; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Lectin; Membrane; Phosphoprotein;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT CHAIN 1..359
FT /note="B-cell differentiation antigen CD72"
FT /id="PRO_0000046585"
FT TOPO_DOM 1..95
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..359
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 232..352
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT MOD_RES 7
FT /note="Phosphotyrosine; by LYN"
FT /evidence="ECO:0000250|UniProtKB:P21855"
FT MOD_RES 39
FT /note="Phosphotyrosine; by LYN"
FT /evidence="ECO:0000250|UniProtKB:P21855"
FT CARBOHYD 136
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 233..244
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 261..350
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 325..342
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT VARIANT 234
FT /note="P -> L (in dbSNP:rs34791102)"
FT /id="VAR_033729"
SQ SEQUENCE 359 AA; 40220 MW; 87A52C028AC17E44 CRC64;
MAEAITYADL RFVKAPLKKS ISSRLGQDPG ADDDGEITYE NVQVPAVLGV PSSLASSVLG
DKAAVKSEQP TASWRAVTSP AVGRILPCRT TCLRYLLLGL LLTCLLLGVT AICLGVRYLQ
VSQQLQQTNR VLEVTNSSLR QQLRLKITQL GQSAEDLQGS RRELAQSQEA LQVEQRAHQA
AEGQLQACQA DRQKTKETLQ SEEQQRRALE QKLSNMENRL KPFFTCGSAD TCCPSGWIMH
QKSCFYISLT SKNWQESQKQ CETLSSKLAT FSEIYPQSHS YYFLNSLLPN GGSGNSYWTG
LSSNKDWKLT DDTQRTRTYA QSSKCNKVHK TWSWWTLESE SCRSSLPYIC EMTAFRFPD
