CD7_MOUSE
ID CD7_MOUSE Reviewed; 210 AA.
AC P50283;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=T-cell antigen CD7;
DE AltName: CD_antigen=CD7;
DE Flags: Precursor;
GN Name=Cd7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7678579; DOI=10.1007/bf00216834;
RA Yoshikawa K., Seto M., Ueda R., Obata Y., Fukatsu H., Segawa A.,
RA Takahashi T.;
RT "Isolation and characterization of mouse CD7 cDNA.";
RL Immunogenetics 37:114-119(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129;
RX PubMed=7509775; DOI=10.1007/bf00188794;
RA Lee D.M., Watson M.L., Seldin M.F.;
RT "Mouse Cd7 maps to chromosome 11.";
RL Immunogenetics 39:289-290(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24 AND 176-210.
RC STRAIN=BALB/cJ; TISSUE=Spleen;
RX PubMed=7528728; DOI=10.1007/bf00182331;
RA Yoshikawa K., Seto M., Ueda R., Obata Y., Aoki S., Takahashi T.;
RT "Molecular cloning of the gene coding for the mouse T-cell antigen CD7.";
RL Immunogenetics 41:159-161(1995).
RN [4]
RP INTERACTION WITH SECTM1.
RX PubMed=10652336; DOI=10.1074/jbc.275.5.3431;
RA Lyman S.D., Escobar S., Rousseau A.-M., Armstrong A., Fanslow W.C.;
RT "Identification of CD7 as a cognate of the human K12 (SECTM1) protein.";
RL J. Biol. Chem. 275:3431-3437(2000).
CC -!- FUNCTION: Not yet known.
CC -!- SUBUNIT: Interacts with SECTM1. {ECO:0000269|PubMed:10652336}.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR EMBL; D10329; BAA01171.1; -; mRNA.
DR EMBL; U23462; AAB17482.1; -; Genomic_DNA.
DR EMBL; D31956; BAA06728.1; -; Genomic_DNA.
DR CCDS; CCDS25764.1; -.
DR PIR; I49294; I49294.
DR RefSeq; NP_033984.1; NM_009854.2.
DR AlphaFoldDB; P50283; -.
DR SMR; P50283; -.
DR BioGRID; 198609; 1.
DR STRING; 10090.ENSMUSP00000026159; -.
DR GlyGen; P50283; 3 sites.
DR iPTMnet; P50283; -.
DR PhosphoSitePlus; P50283; -.
DR PaxDb; P50283; -.
DR PRIDE; P50283; -.
DR ProteomicsDB; 265627; -.
DR ABCD; P50283; 17 sequenced antibodies.
DR Antibodypedia; 3610; 1992 antibodies from 53 providers.
DR DNASU; 12516; -.
DR Ensembl; ENSMUST00000026159; ENSMUSP00000026159; ENSMUSG00000025163.
DR GeneID; 12516; -.
DR KEGG; mmu:12516; -.
DR UCSC; uc007mvc.2; mouse.
DR CTD; 924; -.
DR MGI; MGI:88344; Cd7.
DR VEuPathDB; HostDB:ENSMUSG00000025163; -.
DR eggNOG; ENOG502SD5I; Eukaryota.
DR GeneTree; ENSGT00390000013965; -.
DR HOGENOM; CLU_115462_0_0_1; -.
DR InParanoid; P50283; -.
DR OMA; VYEDMSC; -.
DR OrthoDB; 1083212at2759; -.
DR PhylomeDB; P50283; -.
DR TreeFam; TF338565; -.
DR BioGRID-ORCS; 12516; 2 hits in 75 CRISPR screens.
DR PRO; PR:P50283; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P50283; protein.
DR Bgee; ENSMUSG00000025163; Expressed in animal zygote and 50 other tissues.
DR ExpressionAtlas; P50283; baseline and differential.
DR Genevisible; P50283; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0048873; P:homeostasis of number of cells within a tissue; IMP:MGI.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR039090; CD7.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR15343; PTHR15343; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Adaptive immunity; Disulfide bond; Glycoprotein; Immunity;
KW Immunoglobulin domain; Lipoprotein; Membrane; Palmitate; Receptor;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..210
FT /note="T-cell antigen CD7"
FT /id="PRO_0000014634"
FT TOPO_DOM 24..150
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 24..129
FT /note="Ig-like"
FT LIPID 168
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 86
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 45..111
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CONFLICT 69
FT /note="F -> L (in Ref. 2; AAB17482)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 210 AA; 23153 MW; 0EBD496B8302962B CRC64;
MTQQAVLALL LTLAGILPGP LDAQDVHQSP RLTIASEGDS VNITCSTRGH LEGILMKKIW
PQAYNVIYFE DRQEPTVDRT FSGRINFSGS QKNLTITISS LQLADTGDYT CEAVRKVSAR
GLFTTVVVKE KSSQEAYRSQ EPLQTSFSFP AAIAVGFFFT GLLLGVVCSM LRKIQIKKLC
ASGIKESPCV VYEDMSYSNR KTPCIPNQYQ
