ID   CD80_RABIT              Reviewed;         299 AA.
AC   P42070;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=T-lymphocyte activation antigen CD80;
DE   AltName: Full=Activation B7-1 antigen;
DE   AltName: CD_antigen=CD80;
DE   Flags: Precursor;
GN   Name=CD80;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=B/J X Chbb:HM;
RX   PubMed=7642234; DOI=10.1007/bf00191228;
RA   Isono T., Seto A.;
RT   "Cloning and sequencing of the rabbit gene encoding T-cell costimulatory
RT   molecules.";
RL   Immunogenetics 42:217-220(1995).
CC   -!- FUNCTION: Involved in the costimulatory signal essential for T
CC       lymphocytes activation. T-cell proliferation and cytokine production is
CC       induced by the binding of CD28 or CTLA-4 to this receptor.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D49843; BAA08643.1; -; mRNA.
DR   PIR; I46690; I46690.
DR   RefSeq; NP_001076132.1; NM_001082663.1.
DR   AlphaFoldDB; P42070; -.
DR   SMR; P42070; -.
DR   STRING; 9986.ENSOCUP00000008197; -.
DR   PRIDE; P42070; -.
DR   GeneID; 100009377; -.
DR   KEGG; ocu:100009377; -.
DR   CTD; 941; -.
DR   eggNOG; ENOG502S5B5; Eukaryota.
DR   InParanoid; P42070; -.
DR   OrthoDB; 1083437at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR   GO; GO:0031295; P:T cell costimulation; IEA:InterPro.
DR   CDD; cd16083; IgC_CD80; 1.
DR   CDD; cd16086; IgV_CD80; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR037676; CD80_IgC.
DR   InterPro; IPR042711; CD80_IgV.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF08205; C2-set_2; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Receptor;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000255"
FT   CHAIN           33..299
FT                   /note="T-lymphocyte activation antigen CD80"
FT                   /id="PRO_0000014549"
FT   TOPO_DOM        33..243
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        265..299
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          33..131
FT                   /note="Ig-like V-type"
FT   DOMAIN          144..225
FT                   /note="Ig-like C2-type"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        88
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        97
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        122
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        185
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        206
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        210
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        49..115
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   DISULFID        161..215
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   299 AA;  33514 MW;  6744223E5CC91DE0 CRC64;
     MGHTLRPGTP LPRCLHLKLC LLLALAGLHF SSGISQVTKS VKEMAALSCD YNISIDELAR
     MRIYWQKDQQ MVLSIISGQV EVWPEYKNRT FPDIINNLSL MILALRLSDK GTYTCVVQKN
     ENGSFRREHL TSVTLSIRAD FPVPSITDIG HPDPNVKRIR CSASGGFPEP RLAWMEDGEE
     LNAVNTTVDQ DLDTELYSVS SELDFNVTNN HSIVCLIKYG ELSVSQIFPW SKPKQEPPID
     QLPFWVIIPV SGALVLTAVV LYCLACRHVA RWKRTRRNEE TVGTERLSPI YLGSAQSSG