CD82_MOUSE
ID CD82_MOUSE Reviewed; 266 AA.
AC P40237;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=CD82 antigen;
DE AltName: Full=C33 antigen;
DE AltName: Full=IA4;
DE AltName: Full=Inducible membrane protein R2;
DE AltName: Full=Metastasis suppressor Kangai-1 homolog;
DE AltName: CD_antigen=CD82;
GN Name=Cd82; Synonyms=Kai1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=8039242; DOI=10.1006/cimm.1994.1212;
RA Nagira M., Imai T., Ishikawa I., Uwabe K.I., Yoshie O.;
RT "Mouse homologue of C33 antigen (CD82), a member of the transmembrane 4
RT superfamily: complementary DNA, genomic structure, and expression.";
RL Cell. Immunol. 157:144-157(1994).
RN [2]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-131 AND ASN-157.
RC TISSUE=Myoblast;
RX PubMed=19656770; DOI=10.1074/mcp.m900195-mcp200;
RA Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D.,
RA Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.;
RT "The mouse C2C12 myoblast cell surface N-linked glycoproteome:
RT identification, glycosite occupancy, and membrane orientation.";
RL Mol. Cell. Proteomics 8:2555-2569(2009).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Associates with CD4 or CD8 and delivers costimulatory signals
CC for the TCR/CD3 pathway.
CC -!- SUBUNIT: Interacts directly with IGSF8. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P27701};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Highest expression in the spleen and the kidney.
CC Low expression in skeletal muscle and in the heart.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family. {ECO:0000305}.
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DR EMBL; D14883; BAA03602.1; -; mRNA.
DR CCDS; CCDS16454.1; -.
DR PIR; I49561; I49561.
DR RefSeq; NP_001129527.1; NM_001136055.2.
DR RefSeq; NP_001258359.1; NM_001271430.1.
DR RefSeq; NP_001258360.1; NM_001271431.1.
DR RefSeq; NP_001258361.1; NM_001271432.1.
DR RefSeq; NP_001258390.1; NM_001271461.1.
DR RefSeq; NP_001258391.1; NM_001271462.1.
DR RefSeq; NP_031682.1; NM_007656.5.
DR AlphaFoldDB; P40237; -.
DR SMR; P40237; -.
DR STRING; 10090.ENSMUSP00000028644; -.
DR GlyGen; P40237; 4 sites.
DR iPTMnet; P40237; -.
DR PhosphoSitePlus; P40237; -.
DR SwissPalm; P40237; -.
DR EPD; P40237; -.
DR jPOST; P40237; -.
DR PaxDb; P40237; -.
DR PeptideAtlas; P40237; -.
DR PRIDE; P40237; -.
DR ProteomicsDB; 283753; -.
DR Antibodypedia; 3743; 654 antibodies from 43 providers.
DR DNASU; 12521; -.
DR Ensembl; ENSMUST00000028644; ENSMUSP00000028644; ENSMUSG00000027215.
DR Ensembl; ENSMUST00000099696; ENSMUSP00000097287; ENSMUSG00000027215.
DR Ensembl; ENSMUST00000111257; ENSMUSP00000106888; ENSMUSG00000027215.
DR Ensembl; ENSMUST00000116457; ENSMUSP00000112158; ENSMUSG00000027215.
DR GeneID; 12521; -.
DR KEGG; mmu:12521; -.
DR UCSC; uc008lfx.2; mouse.
DR CTD; 3732; -.
DR MGI; MGI:104651; Cd82.
DR VEuPathDB; HostDB:ENSMUSG00000027215; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000158481; -.
DR InParanoid; P40237; -.
DR OMA; NIHSEDY; -.
DR OrthoDB; 1207549at2759; -.
DR PhylomeDB; P40237; -.
DR TreeFam; TF352892; -.
DR BioGRID-ORCS; 12521; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Cd82; mouse.
DR PRO; PR:P40237; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P40237; protein.
DR Bgee; ENSMUSG00000027215; Expressed in parotid gland and 249 other tissues.
DR ExpressionAtlas; P40237; baseline and differential.
DR Genevisible; P40237; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR Gene3D; 1.10.1450.10; -; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; PTHR19282; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR SUPFAM; SSF48652; SSF48652; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..266
FT /note="CD82 antigen"
FT /id="PRO_0000219227"
FT TOPO_DOM 1..11
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..53
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..110
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..227
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..266
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 131
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19656770"
FT CARBOHYD 157
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19656770"
FT CARBOHYD 197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 266 AA; 29629 MW; CB4BE669E7C52D57 CRC64;
MGAGCVKVTK YFLFLFNLLF FILGAVILGF GVWILADKNS FISVLQTSSS SLQVGAYVFI
GVGAITIVMG FLGCIGAVNE VRCLLGLYFV FLLLILIAQV TVGVLFYFNA DKLKKEMGNT
VMDIIRNYTA NATSSREEAW DYVQAQVKCC GWVSHYNWTE NEELMGFTKT TYPCSCEKIK
EEDNQLIVKK GFCEADNSTV SENNPEDWPV NTEGCMEKAQ AWLQENFGIL LGVCAGVAVI
ELLGLFLSIC LCRYIHSEDY SKVPKY
