CD8B2_HUMAN
ID CD8B2_HUMAN Reviewed; 210 AA.
AC A6NJW9; A0A2R8Y7N9;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-JUL-2019, sequence version 3.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=T-cell surface glycoprotein CD8 beta-2 chain;
DE AltName: Full=CD8b pseudogene {ECO:0000312|HGNC:HGNC:1708};
DE Flags: Precursor;
GN Name=CD8B2 {ECO:0000312|HGNC:HGNC:1708};
GN Synonyms=CD8BP {ECO:0000312|HGNC:HGNC:1708};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1541829;
RA Nakayama K., Kawachi Y., Tokito S., Minami N., Yamamoto R., Imai T.,
RA Gachelin G., Nakauchi H.;
RT "Recent duplication of the two human CD8 beta-chain genes.";
RL J. Immunol. 148:1919-1927(1992).
RN [3]
RP IDENTIFICATION.
RX PubMed=8436166; DOI=10.1002/eji.1830230203;
RA DiSanto J.P., Smith D., de Bruin D., Lacy E., Flomenberg N.;
RT "Transcriptional diversity at the duplicated human CD8 beta loci.";
RL Eur. J. Immunol. 23:320-326(1993).
CC -!- FUNCTION: Identifies cytotoxic/suppressor T-cells that interact with
CC MHC class I bearing targets. CD8 is thought to play a role in the
CC process of T-cell mediated killing (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: In general heterodimer of an alpha and a beta chain linked by
CC two disulfide bonds.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}.
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DR EMBL; AC108868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS86870.1; -.
DR AlphaFoldDB; A6NJW9; -.
DR SMR; A6NJW9; -.
DR GlyGen; A6NJW9; 1 site.
DR BioMuta; HGNC:1708; -.
DR MassIVE; A6NJW9; -.
DR PeptideAtlas; A6NJW9; -.
DR PRIDE; A6NJW9; -.
DR ProteomicsDB; 1359; -.
DR Ensembl; ENST00000643224.2; ENSP00000496416.1; ENSG00000254126.8.
DR MANE-Select; ENST00000643224.2; ENSP00000496416.1; NM_001349727.2; NP_001336656.1.
DR GeneCards; CD8B2; -.
DR HGNC; HGNC:1708; CD8B2.
DR HPA; ENSG00000254126; Tissue enhanced (brain, lymphoid tissue).
DR neXtProt; NX_A6NJW9; -.
DR OpenTargets; ENSG00000254126; -.
DR VEuPathDB; HostDB:ENSG00000254126; -.
DR GeneTree; ENSGT00510000048998; -.
DR InParanoid; A6NJW9; -.
DR OMA; TEMICAV; -.
DR PhylomeDB; A6NJW9; -.
DR ChiTaRS; CD8BP; human.
DR Pharos; A6NJW9; Tdark.
DR PRO; PR:A6NJW9; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; A6NJW9; protein.
DR Bgee; ENSG00000254126; Expressed in calcaneal tendon and 60 other tissues.
DR ExpressionAtlas; A6NJW9; baseline and differential.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR GO; GO:0042288; F:MHC class I protein binding; IEA:InterPro.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0050776; P:regulation of immune response; IEA:InterPro.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR042414; CD8B.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR11292; PTHR11292; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 3: Inferred from homology;
KW Adaptive immunity; Cell membrane; Disulfide bond; Glycoprotein; Immunity;
KW Immunoglobulin domain; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..210
FT /note="T-cell surface glycoprotein CD8 beta-2 chain"
FT /id="PRO_0000341228"
FT TOPO_DOM 19..170
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..210
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 19..132
FT /note="Ig-like V-type"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 41..116
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 210 AA; 23703 MW; 655DA41485245029 CRC64;
MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM CIYWLRQRQA
PSSDSHHEFL TLWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG
SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP VTLGLLVAGV
LVLLVSLGVA MHLCCRRRRA RLRFMKQFYK
