CD99_MOUSE
ID CD99_MOUSE Reviewed; 175 AA.
AC Q8VCN6; Q4L299; Q4L2A4; Q8BLN1;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=CD99 antigen;
DE AltName: Full=Paired immunoglobin-like type 2 receptor-ligand;
DE Short=PILR-L;
DE AltName: CD_antigen=CD99;
DE Flags: Precursor;
GN Name=Cd99; Synonyms=Pilrl;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INTERACTION WITH PILRB.
RX PubMed=14970179; DOI=10.1084/jem.20031885;
RA Shiratori I., Ogasawara K., Saito T., Lanier L.L., Arase H.;
RT "Activation of natural killer cells and dendritic cells upon recognition of
RT a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor.";
RL J. Exp. Med. 199:525-533(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND SUBUNIT.
RC TISSUE=Testis;
RX PubMed=15978751; DOI=10.1016/j.gene.2005.04.023;
RA Park S.H., Shin Y.K., Suh Y.H., Park W.S., Ban Y.L., Choi H.S., Park H.J.,
RA Jung K.C.;
RT "Rapid divergency of rodent CD99 orthologs: implications for the evolution
RT of the pseudoautosomal region.";
RL Gene 353:177-188(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=15280198; DOI=10.1182/blood-2004-03-1184;
RA Bixel G., Kloep S., Butz S., Petri B., Engelhardt B., Vestweber D.;
RT "Mouse CD99 participates in T-cell recruitment into inflamed skin.";
RL Blood 104:3205-3213(2004).
RN [6]
RP FUNCTION.
RX PubMed=20479283; DOI=10.1182/blood-2009-12-256388;
RA Bixel M.G., Li H., Petri B., Khandoga A.G., Khandoga A., Zarbock A.,
RA Wolburg-Buchholz K., Wolburg H., Sorokin L., Zeuschner D., Maerz S.,
RA Butz S., Krombach F., Vestweber D.;
RT "CD99 and CD99L2 act at the same site as, but independently of, PECAM-1
RT during leukocyte diapedesis.";
RL Blood 116:1172-1184(2010).
CC -!- FUNCTION: Involved in T-cell adhesion processes. Plays a role in a late
CC step of leukocyte extravasation helping leukocytes to overcome the
CC endothelial basement membrane. Acts at the same site as, but
CC independently of, PECAM1. {ECO:0000269|PubMed:15280198,
CC ECO:0000269|PubMed:20479283}.
CC -!- SUBUNIT: Homodimer. Interacts with PILRB. {ECO:0000269|PubMed:14970179,
CC ECO:0000269|PubMed:15978751}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Widely expressed with high levels in lung, spleen,
CC thymus, liver and spinal chord. Expressed on leukocytes and endothelial
CC cell contacts. Detected in a wide range of T-cells, including
CC CD4-/CD8- and CD4+/CD8+ thymocytes. Expression is much lower in
CC peripheral T-cells than in thymocytes. {ECO:0000269|PubMed:14970179,
CC ECO:0000269|PubMed:15280198}.
CC -!- SIMILARITY: Belongs to the CD99 family. {ECO:0000305}.
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DR EMBL; AY262359; AAP91691.1; -; Genomic_DNA.
DR EMBL; AY262355; AAP91687.1; -; mRNA.
DR EMBL; AK044051; BAC31754.1; -; mRNA.
DR EMBL; BC019482; AAH19482.1; -; mRNA.
DR RefSeq; NP_079860.2; NM_025584.2.
DR AlphaFoldDB; Q8VCN6; -.
DR IntAct; Q8VCN6; 3.
DR PhosphoSitePlus; Q8VCN6; -.
DR jPOST; Q8VCN6; -.
DR MaxQB; Q8VCN6; -.
DR PRIDE; Q8VCN6; -.
DR ProteomicsDB; 283754; -.
DR DNASU; 673094; -.
DR GeneID; 673094; -.
DR KEGG; mmu:673094; -.
DR CTD; 4267; -.
DR MGI; MGI:1913728; Cd99.
DR InParanoid; Q8VCN6; -.
DR PRO; PR:Q8VCN6; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8VCN6; protein.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0034109; P:homotypic cell-cell adhesion; IDA:MGI.
DR GO; GO:0001773; P:myeloid dendritic cell activation; IDA:MGI.
DR GO; GO:2000391; P:positive regulation of neutrophil extravasation; IMP:MGI.
DR GO; GO:0072683; P:T cell extravasation; IMP:MGI.
DR InterPro; IPR022078; CD99L2.
DR PANTHER; PTHR15076; PTHR15076; 1.
DR Pfam; PF12301; CD99L2; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..175
FT /note="CD99 antigen"
FT /id="PRO_0000226820"
FT TOPO_DOM 29..137
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 159..175
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 30..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 100
FT /note="D -> G (in Ref. 3; BAC31754)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="Missing (in Ref. 2; AAP91687/AAP91691 and 3;
FT BAC31754)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="R -> P (in Ref. 2; AAP91687/AAP91691)"
FT /evidence="ECO:0000305"
FT CONFLICT 128
FT /note="G -> R (in Ref. 2; AAP91687)"
FT /evidence="ECO:0000305"
FT CONFLICT 148..149
FT /note="AA -> PP (in Ref. 3; BAC31754)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 175 AA; 16783 MW; A309E6E2494FBFE1 CRC64;
MARAAMEAAA TVVLALALLG AAARGAASDD FNLGDALEDP NMKPTPKAPT PKKPSGGFDL
EDALPGGGGG GAGEKPGNRP QPDPKPPRPH GDSGGISDSD LADAAGQGGG GAGRRGSGDE
GGHGGAGGAE PEGTPQGLVP GVVAAVVAAV AGAVSSFVAY QRRRLCFREG GSAPV
