CDAR_ECOLI
ID CDAR_ECOLI Reviewed; 385 AA.
AC P37047; Q8KJQ0;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-1998, sequence version 2.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Carbohydrate diacid regulator;
DE AltName: Full=Sugar diacid regulator;
GN Name=cdaR; Synonyms=sdaR, yaeG; OrderedLocusNames=b0162, JW5013;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8202364; DOI=10.1093/nar/22.9.1637;
RA Fujita N., Mori H., Yura T., Ishihama A.;
RT "Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-
RT 4.1 min (110,917-193,643 bp) region.";
RL Nucleic Acids Res. 22:1637-1639(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP CHARACTERIZATION.
RC STRAIN=K12 / MC4100 / ATCC 35695 / DSM 6574, and K12 / MC4100 / JA176;
RX PubMed=10762278; DOI=10.1128/jb.182.9.2672-2674.2000;
RA Monterrubio R., Baldoma L., Obradors N., Aguilar J., Badia J.;
RT "A common regulator for the operons encoding the enzymes involved in D-
RT galactarate, D-glucarate, and D-glycerate utilization in Escherichia
RT coli.";
RL J. Bacteriol. 182:2672-2674(2000).
CC -!- FUNCTION: Seems to regulate the expression of the operons for the
CC enzymes involved in D-galactarate, D-glucarate and D-glycerate
CC utilization.
CC -!- SIMILARITY: Belongs to the CdaR family. {ECO:0000305}.
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DR EMBL; U70214; AAB08592.1; -; Genomic_DNA.
DR EMBL; U00096; AAC73273.2; -; Genomic_DNA.
DR EMBL; AP009048; BAB96739.2; -; Genomic_DNA.
DR PIR; B64740; B64740.
DR RefSeq; NP_414704.4; NC_000913.3.
DR RefSeq; WP_000929443.1; NZ_SSZK01000004.1.
DR AlphaFoldDB; P37047; -.
DR SMR; P37047; -.
DR BioGRID; 4260992; 14.
DR DIP; DIP-9258N; -.
DR STRING; 511145.b0162; -.
DR jPOST; P37047; -.
DR PaxDb; P37047; -.
DR PRIDE; P37047; -.
DR EnsemblBacteria; AAC73273; AAC73273; b0162.
DR EnsemblBacteria; BAB96739; BAB96739; BAB96739.
DR GeneID; 944860; -.
DR KEGG; ecj:JW5013; -.
DR KEGG; eco:b0162; -.
DR PATRIC; fig|1411691.4.peg.2118; -.
DR EchoBASE; EB2239; -.
DR eggNOG; COG3835; Bacteria.
DR HOGENOM; CLU_043769_1_0_6; -.
DR InParanoid; P37047; -.
DR OMA; NTRHEGA; -.
DR PhylomeDB; P37047; -.
DR BioCyc; EcoCyc:EG12335-MON; -.
DR PRO; PR:P37047; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:EcoCyc.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:EcoCyc.
DR Gene3D; 1.10.10.2840; -; 1.
DR InterPro; IPR041522; CdaR_GGDEF.
DR InterPro; IPR008599; Diacid_rec.
DR InterPro; IPR025736; PucR_C-HTH_dom.
DR InterPro; IPR042070; PucR_C-HTH_sf.
DR Pfam; PF05651; Diacid_rec; 1.
DR Pfam; PF17853; GGDEF_2; 1.
DR Pfam; PF13556; HTH_30; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..385
FT /note="Carbohydrate diacid regulator"
FT /id="PRO_0000165944"
FT VARIANT 292
FT /note="P -> S (in strain: JA176; unable to grow on
FT galactarate, glucarate and glycerate)"
SQ SEQUENCE 385 AA; 43687 MW; 5FD4EEFB33C44DBB CRC64;
MAGWHLDTKM AQDIVARTMR IIDTNINVMD ARGRIIGSGD RERIGELHEG ALLVLSQGRV
VDIDDAVARH LHGVRQGINL PLRLEGEIVG VIGLTGEPEN LRKYGELVCM TAEMMLEQSR
LMHLLAQDSR LREELVMNLI QAEENTPALT EWAQRLGIDL NQPRVVAIVE VDSGQLGVDS
AMAELQQLQN ALTTPERNNL VAIVSLTEMV VLKPALNSFG RWDAEDHRKR VEQLITRMKE
YGQLRFRVSL GNYFTGPGSI ARSYRTAKTT MVVGKQRMPE SRCYFYQDLM LPVLLDSLRG
DWQANELARP LARLKTMDNN GLLRRTLAAW FRHNVQPLAT SKALFIHRNT LEYRLNRISE
LTGLDLGNFD DRLLLYVALQ LDEER
