CDAT_PLAF7
ID CDAT_PLAF7 Reviewed; 1229 AA.
AC P46468; Q8IBY0;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Putative cell division cycle ATPase;
GN ORFNames=PF07_0047;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 379-1087.
RA Sims P.F.G., Hyde J.E.;
RT "Identification of a Plasmodium falciparum gene encoding a putative cell
RT division cycle component.";
RL Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR EMBL; AL844506; CAD50861.1; -; Genomic_DNA.
DR EMBL; M96757; AAA29520.1; -; Genomic_DNA.
DR RefSeq; XP_001349023.1; XM_001348987.1.
DR AlphaFoldDB; P46468; -.
DR SMR; P46468; -.
DR BioGRID; 1209952; 1.
DR IntAct; P46468; 1.
DR STRING; 5833.PF07_0047; -.
DR TCDB; 3.A.25.2.1; the symbiont-specific erad-like machinery (selma) family.
DR SwissPalm; P46468; -.
DR PRIDE; P46468; -.
DR EnsemblProtists; CAD50861; CAD50861; PF3D7_0711000.
DR GeneID; 2655095; -.
DR KEGG; pfa:PF3D7_0711000; -.
DR VEuPathDB; PlasmoDB:PF3D7_0711000; -.
DR HOGENOM; CLU_000688_12_3_1; -.
DR InParanoid; P46468; -.
DR OMA; RCSIFKA; -.
DR PhylomeDB; P46468; -.
DR Proteomes; UP000001450; Chromosome 7.
DR GO; GO:0020011; C:apicoplast; IDA:GeneDB.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0034098; C:VCP-NPL4-UFD1 AAA ATPase complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR GO; GO:0043130; F:ubiquitin binding; TAS:GeneDB.
DR GO; GO:0097352; P:autophagosome maturation; IBA:GO_Central.
DR GO; GO:0071712; P:ER-associated misfolded protein catabolic process; IBA:GO_Central.
DR GO; GO:0051228; P:mitotic spindle disassembly; IBA:GO_Central.
DR GO; GO:0010564; P:regulation of cell cycle process; IDA:GeneDB.
DR GO; GO:0030970; P:retrograde protein transport, ER to cytosol; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; EXP:GeneDB.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR029067; CDC48_domain_2-like_sf.
DR InterPro; IPR003338; CDC4_N-term_subdom.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF17862; AAA_lid_3; 2.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01073; CDC48_N; 1.
DR SUPFAM; SSF50692; SSF50692; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF54585; SSF54585; 1.
DR PROSITE; PS00674; AAA; 2.
PE 3: Inferred from homology;
KW ATP-binding; Cell cycle; Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..1229
FT /note="Putative cell division cycle ATPase"
FT /id="PRO_0000084593"
FT REGION 252..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 814..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 860..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..315
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..837
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 568..575
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 975..982
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT CONFLICT 834
FT /note="D -> N (in Ref. 3; AAA29520)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1229 AA; 142080 MW; 5DA03A25EA4E4FA8 CRC64;
MKVRKMHYPL FSFTEYLSCY IILYFFVFLP NYSYAININN YHNKNNLWNI NNKWNNQQSN
HFSNNRIGHF LWGSKIRKNP LASISTSITT KKLENQKKKT NKNESYSNVN DKYEHNNNTA
HFVQINYKND QSNDTLSTYK NNNEMTVEGK PNNLASGEGK KEIHNTTQKI LEKVDYFKER
EKITNSYNNN NNNNKVIVTH DNKNHTNYIN KVENKQSDDK IKNLNNKYIK KFKSHILQND
ILGTISTMFW SGKKNNNGNV KKGIKNVPMD EKSYSPNDHD NNSNNSNNNN NNDNNNSNNN
NNNNNGGKNN SYYNEKTQKG VNDKETNFLL KALDSGKFPT YCLVENIDEN LDNFDIYMSK
EKMDELNIND GATVLLKGKK KREMLGIARL DRSLKKHYVV ISFAMKKNLR LMHNDIIKIH
PFMNAKRIRN VVLSPFSDTI PNLSREELEK AVIHPYLKNS YKPLRVNSNI YIYYKNNKIE
FKVLKIISEE SENEEFGCIG EHSQLTLAEE YLKREDYEEN NDDITYEDLG GMKKQLNKIR
ELIELPLKYP EIFMSIGISA PKGVLMHGIP GTGKTSIAKA IANESNAYCY IINGPEIMSK
HIGESEQKLR KIFKKASEKT PCIIFIDEID SIANKRSKSN NELEKRVVSQ LLTLMDGLKK
NNNVLVLAAT NRPNSIDPAL RRFGRFDREI EIPVPDEQGR YEILLTKTKK MKLDPDVNLR
KIAKECHGYV GADLAQLCFE AAIQCIKEHI HFLDLDEEDF IEFMKISVDE DKKNMGNEPY
GSSHTNNSNY INHLTESSNK LSYTNMFPLN RKNTLLQNDK NEMNKDSSYD KKTDALDNYK
NDSTIDMEKK KNKKKSNFFF SNDDEETKNK NKTNVNQKKK KNPNDKLDKN ERRIPAYILN
KLTIKAKHFQ HALNICNPSS LRERQVQIPT VTWNDIGGMN EVKEQLKETI LYPLEYKHLY
NKFNSNYNKG ILLYGPPGCG KTLLAKAIAN ECKANFISVK GPELLTMWFG ESEANVRDLF
DKARAASPCI IFFDEIDSLA KERNSNTNND ASDRVINQIL TEIDGINEKK TIFIIAATNR
PDILDKALTR PGRLDKLIYI SLPDLKSRYS IFKAILKNTP LNEDVDIHDM AKRTEGFSGA
DITNLCQSAV NEAIKETIHL LNIRKKEQEE QRKKNKNSFK IDDTDTYDPV PTLSKKHFDL
AFKNARISIQ PEDVLKYEKF KEKLSLQDF
