ID   CDA_CONDE               Reviewed;          34 AA.
AC   P84698;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Conotoxin de13a;
DE   Flags: Precursor;
OS   Conus delessertii (Sozon's cone) (Conus sozoni).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conasprella; Kohniconus.
OX   NCBI_TaxID=2547900;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-32, SUBCELLULAR LOCATION,
RP   TISSUE SPECIFICITY, MASS SPECTROMETRY, HYDROXYLATION AT PRO-3; PRO-7;
RP   LYS-18; PRO-21 AND LYS-25, BROMINATION AT TRP-14, AND AMIDATION AT HIS-32.
RC   TISSUE=Venom {ECO:0000269|PubMed:16101297};
RX   PubMed=16101297; DOI=10.1021/bi050518l;
RA   Aguilar M.B., Lopez-Vera E., Ortiz E., Becerril B., Possani L.D.,
RA   Olivera B.M., Heimer de la Cotera E.P.;
RT   "A novel conotoxin from Conus delessertii with posttranslationally modified
RT   lysine residues.";
RL   Biochemistry 44:11130-11136(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16101297}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000269|PubMed:16101297}.
CC   -!- DOMAIN: The cysteine framework is XIII (C-C-C-CC-C-C-C).
CC   -!- PTM: Contains 4 disulfide bonds.
CC   -!- PTM: The diastereomeric form of 5-hydroxylysine found was not
CC       conclusively established, but it is probably 5R.
CC   -!- MASS SPECTROMETRY: Mass=3486.76; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:16101297};
CC   -!- SIMILARITY: Belongs to the conotoxin G superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P84698; -.
DR   ConoServer; 1500; De13a precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Bromination; Direct protein sequencing; Disulfide bond;
KW   Hydroxylation; Secreted; Toxin.
FT   PEPTIDE         1..32
FT                   /note="Conotoxin de13a"
FT                   /id="PRO_0000042683"
FT   MOD_RES         3
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:16101297"
FT   MOD_RES         7
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:16101297"
FT   MOD_RES         14
FT                   /note="6'-bromotryptophan"
FT                   /evidence="ECO:0000269|PubMed:16101297"
FT   MOD_RES         18
FT                   /note="5-hydroxylysine"
FT                   /evidence="ECO:0000269|PubMed:16101297"
FT   MOD_RES         21
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:16101297"
FT   MOD_RES         25
FT                   /note="5-hydroxylysine"
FT                   /evidence="ECO:0000269|PubMed:16101297"
FT   MOD_RES         32
FT                   /note="Histidine amide"
FT                   /evidence="ECO:0000269|PubMed:16101297"
FT   CONFLICT        5
FT                   /note="R -> S (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   34 AA;  3595 MW;  F58FD10670E9CC0D CRC64;
     DCPTRCPTTC ANGWECCKGY PCVNKACSGC THGK