ID   CDB_CONDE               Reviewed;          71 AA.
AC   P0DM34; S4V9Q1;
DT   29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2013, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Conotoxin De13.1;
DE   AltName: Full=de13b;
DE   Flags: Precursor;
OS   Conus delessertii (Sozon's cone) (Conus sozoni).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conasprella; Kohniconus.
OX   NCBI_TaxID=2547900;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND GAMMA-CARBOXYGLUTAMATION AT GLU-52.
RC   TISSUE=Venom duct;
RX   PubMed=23340018; DOI=10.1016/j.peptides.2013.01.009;
RA   Aguilar M.B., Ortiz E., Kaas Q., Lopez-Vera E., Becerril B., Possani L.D.,
RA   de la Cotera E.P.;
RT   "Precursor De13.1 from Conus delessertii defines the novel G gene
RT   superfamily.";
RL   Peptides 41:17-20(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The cysteine framework is XIII (C-C-C-CC-C-C-C).
CC   -!- PTM: Contains 4 disulfide bonds.
CC   -!- SIMILARITY: Belongs to the conotoxin G superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KC782513; AGO59814.1; -; mRNA.
DR   AlphaFoldDB; P0DM34; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Bromination; Cleavage on pair of basic residues; Disulfide bond;
KW   Gamma-carboxyglutamic acid; Hydroxylation; Secreted; Signal; Toxin.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..35
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000422425"
FT   CHAIN           38..69
FT                   /note="Conotoxin De13.1"
FT                   /id="PRO_0000422426"
FT   MOD_RES         40
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         44
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         51
FT                   /note="6'-bromotryptophan"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         52
FT                   /note="4-carboxyglutamate"
FT                   /evidence="ECO:0000303|PubMed:23340018"
FT   MOD_RES         55
FT                   /note="5-hydroxylysine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         58
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         69
FT                   /note="Histidine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   71 AA;  7554 MW;  888A81EE0DD91AD6 CRC64;
     MSGMGVLLLV LLLVMPLAAF HQDGEGEATR RSGGLKRDCP TSCPTTCANG WECCKGYPCV
     RQHCSGCNHG K