CDC14_SCHPO
ID CDC14_SCHPO Reviewed; 240 AA.
AC P36589;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Cell division control protein 14;
GN Name=cdc14; ORFNames=SPBC24C6.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=8334307; DOI=10.1091/mbc.4.5.531;
RA Fankhauser C., Simanis V.;
RT "The Schizosaccharomyces pombe cdc14 gene is required for septum formation
RT and can also inhibit nuclear division.";
RL Mol. Biol. Cell 4:531-539(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP FUNCTION, INTERACTION WITH SID1, AND SUBCELLULAR LOCATION.
RX PubMed=11384993; DOI=10.1074/jbc.m103802200;
RA Guertin D.A., McCollum D.;
RT "Interaction between the noncatalytic region of Sid1p kinase and Cdc14p is
RT required for full catalytic activity and localization of Sid1p.";
RL J. Biol. Chem. 276:28185-28189(2001).
RN [4]
RP FUNCTION, INTERACTION WITH SID1, AND SUBCELLULAR LOCATION.
RX PubMed=10775265; DOI=10.1093/emboj/19.8.1803;
RA Guertin D.A., Chang L., Irshad F., Gould K.L., McCollum D.;
RT "The role of the sid1p kinase and cdc14p in regulating the onset of
RT cytokinesis in fission yeast.";
RL EMBO J. 19:1803-1815(2000).
CC -!- FUNCTION: Has a role in the septation initiation network (SIN) required
CC for cytokinesis. {ECO:0000269|PubMed:10775265,
CC ECO:0000269|PubMed:11384993}.
CC -!- SUBUNIT: Interacts with sid1. {ECO:0000269|PubMed:10775265,
CC ECO:0000269|PubMed:11384993}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, spindle pole body {ECO:0000269|PubMed:10775265,
CC ECO:0000269|PubMed:11384993}. Note=Localizes to the SPB prior to
CC cytokinesis and leaves once septation is complete.
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DR EMBL; X72911; CAA51416.1; -; Genomic_DNA.
DR EMBL; CU329671; CAA21151.1; -; Genomic_DNA.
DR PIR; A47731; S35794.
DR RefSeq; NP_595961.1; NM_001021870.2.
DR AlphaFoldDB; P36589; -.
DR SMR; P36589; -.
DR BioGRID; 277150; 32.
DR STRING; 4896.SPBC24C6.07.1; -.
DR MaxQB; P36589; -.
DR PaxDb; P36589; -.
DR EnsemblFungi; SPBC24C6.07.1; SPBC24C6.07.1:pep; SPBC24C6.07.
DR GeneID; 2540624; -.
DR KEGG; spo:SPBC24C6.07; -.
DR PomBase; SPBC24C6.07; cdc14.
DR VEuPathDB; FungiDB:SPBC24C6.07; -.
DR eggNOG; ENOG502S6JC; Eukaryota.
DR HOGENOM; CLU_052857_0_0_1; -.
DR InParanoid; P36589; -.
DR OMA; LEPANCP; -.
DR PhylomeDB; P36589; -.
DR PRO; PR:P36589; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0071958; C:new mitotic spindle pole body; IDA:PomBase.
DR GO; GO:0030295; F:protein kinase activator activity; IDA:PomBase.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0031028; P:septation initiation signaling; EXP:PomBase.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012535; Cell_div_Cdc14.
DR PANTHER; PTHR34065; PTHR34065; 2.
DR Pfam; PF08045; CDC14; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Mitosis;
KW Reference proteome.
FT CHAIN 1..240
FT /note="Cell division control protein 14"
FT /id="PRO_0000089442"
SQ SEQUENCE 240 AA; 28161 MW; 4E67626A0C8E0716 CRC64;
MEDLLNNAKQ HLCMRNPKLI RIGLRQVESI VYHVAKPSHD DKIPREIFLK LQDSPLYNST
TPCIYALDSL LEYQQNEEAY EKNFQFIQKL IDDLLHVIEG LVLIHPKSQT LFEDKATLRL
FIHLLQPSQP SMLQVAAMKT LVCIMADRPL AIRLFEQING LQQICVVFKH KQTSQDTRFQ
ILEFFYFYLS PEPYSIDVIA YRKTRTEKQA YLSKYLSNVQ GLRDDLDKFQ PFGKLDETFD
