CDC16_ARATH
ID CDC16_ARATH Reviewed; 543 AA.
AC B3DNN5; Q8GXT0; Q8L5J4; Q8LEK0; Q9ZV95;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Anaphase-promoting complex subunit 6;
DE AltName: Full=Cell division cycle protein 16 homolog;
DE Short=CDC16 homolog;
DE AltName: Full=Cyclosome subunit 6;
DE AltName: Full=Protein NOMEGA;
GN Name=APC6; Synonyms=CDC16; OrderedLocusNames=At1g78770; ORFNames=F9K20.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=cv. Landsberg erecta; TISSUE=Flower;
RX PubMed=14675450; DOI=10.1046/j.1365-313x.2003.01925.x;
RA Kwee H.S., Sundaresan V.;
RT "The NOMEGA gene required for female gametophyte development encodes the
RT putative APC6/CDC16 component of the anaphase promoting complex in
RT Arabidopsis.";
RL Plant J. 36:853-866(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA De Los Reyes C., Quan R., Chen H., Bautista V.R., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 376-543.
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 399-543.
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [7]
RP FUNCTION OF THE APC/C COMPLEX.
RX PubMed=19336465; DOI=10.1242/dev.035535;
RA Marrocco K., Thomann A., Parmentier Y., Genschik P., Criqui M.C.;
RT "The APC/C E3 ligase remains active in most post-mitotic Arabidopsis cells
RT and is required for proper vasculature development and organization.";
RL Development 136:1475-1485(2009).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. The APC/C complex controls several key steps in the cell cycle
CC by mediating ubiquitination and subsequent degradation of target
CC proteins such as cyclins. The APC/C complex is required for the female
CC gametophyte development and is involved in several aspect of
CC development by controlling cell division and cell elongation. Involved
CC in the control of endoreduplication. {ECO:0000269|PubMed:14675450,
CC ECO:0000269|PubMed:19336465}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: The APC/C is composed of at least 10 subunits.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:14675450}.
CC -!- DISRUPTION PHENOTYPE: Gametophytic lethal phenotype.
CC {ECO:0000269|PubMed:14675450}.
CC -!- SIMILARITY: Belongs to the APC6/CDC16 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC83033.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAM62610.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF529177; AAM95623.1; -; mRNA.
DR EMBL; AC005679; AAC83033.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE36148.1; -; Genomic_DNA.
DR EMBL; BT033023; ACE62891.1; -; mRNA.
DR EMBL; AY085381; AAM62610.1; ALT_INIT; mRNA.
DR EMBL; AK118058; BAC42689.1; -; mRNA.
DR PIR; G96816; G96816.
DR RefSeq; NP_565188.1; NM_106524.2.
DR AlphaFoldDB; B3DNN5; -.
DR SMR; B3DNN5; -.
DR BioGRID; 29432; 14.
DR IntAct; B3DNN5; 14.
DR STRING; 3702.AT1G78770.1; -.
DR PaxDb; B3DNN5; -.
DR PRIDE; B3DNN5; -.
DR ProteomicsDB; 224387; -.
DR EnsemblPlants; AT1G78770.1; AT1G78770.1; AT1G78770.
DR GeneID; 844213; -.
DR Gramene; AT1G78770.1; AT1G78770.1; AT1G78770.
DR KEGG; ath:AT1G78770; -.
DR Araport; AT1G78770; -.
DR TAIR; locus:2037523; AT1G78770.
DR eggNOG; KOG1173; Eukaryota.
DR HOGENOM; CLU_011751_3_1_1; -.
DR InParanoid; B3DNN5; -.
DR OMA; DPFHNNA; -.
DR OrthoDB; 905026at2759; -.
DR PhylomeDB; B3DNN5; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:B3DNN5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; B3DNN5; baseline and differential.
DR Genevisible; B3DNN5; AT.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IBA:GO_Central.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0010087; P:phloem or xylem histogenesis; IMP:TAIR.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0032875; P:regulation of DNA endoreduplication; IMP:TAIR.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR011716; TPR-3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF07720; TPR_3; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50005; TPR; 7.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 2: Evidence at transcript level;
KW Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome; Repeat;
KW TPR repeat; Ubl conjugation pathway.
FT CHAIN 1..543
FT /note="Anaphase-promoting complex subunit 6"
FT /id="PRO_0000396844"
FT REPEAT 7..36
FT /note="TPR 1"
FT REPEAT 39..64
FT /note="TPR 2"
FT REPEAT 72..95
FT /note="TPR 3"
FT REPEAT 128..159
FT /note="TPR 4"
FT REPEAT 164..187
FT /note="TPR 5"
FT REPEAT 194..232
FT /note="TPR 6"
FT REPEAT 242..270
FT /note="TPR 7"
FT REPEAT 277..304
FT /note="TPR 8"
FT REPEAT 309..338
FT /note="TPR 9"
FT REPEAT 343..371
FT /note="TPR 10"
FT REPEAT 378..406
FT /note="TPR 11"
FT REPEAT 411..443
FT /note="TPR 12"
FT REPEAT 447..479
FT /note="TPR 13"
FT REPEAT 484..513
FT /note="TPR 14"
SQ SEQUENCE 543 AA; 61762 MW; 87A97D87BC29E36D CRC64;
MREEEIEKIR GVVRDCVSKH LYSSAIFFAD KVAALTNDPS DIYMQAQALF LGRHYRRAFH
LLNASKIVLR DLRFRYLAAK CLEELKEWDQ CLLMLGDAKV DDDGIVYDAK DGNVIDFDKD
GEDREINISS AICFLRGKAY GALQNRSQAR QWYKAAIKAD PLCYEALECL IESHMLTSEE
ESSLLSSLQF SPEDGWLSSF YSCLIKKYDK ESTVELKFKK LENETSGSVS GSSMITLANN
TDLLACKAEY YHQCCEYQKC FELTAALLEK DPFHLKCTLV HLAAAMELGN SNELYLMACN
LVKDYPSKAL SWFAVGCYYY CIKKYAEARR YFSKATGIDG SFSPARIGYG NSFAAQEEGD
QAMSAYRTAA RLFPGCHLPT LYIGMEYMRT HSYKLADQFF MQAKAICPSD PLVYNELGVV
AYHMKEYGKA VRWFEKTLAH IPSALTESWE PTVVNLAHAY RKLRKDREAI SYYERALTLS
TKSLSTYSGL AYTYHLQGNF SAAISYYHKA LWLKPDDQFC TEMLNVALMD ECQNGVDSKV
ELC
