CDC16_SCHPO
ID CDC16_SCHPO Reviewed; 299 AA.
AC P36618;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 25-MAY-2022, entry version 138.
DE RecName: Full=Cell division control protein 16;
GN Name=cdc16; Synonyms=bub2; ORFNames=SPAC6F6.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=8334988; DOI=10.1002/j.1460-2075.1993.tb05931.x;
RA Fankhauser C., Marks J., Reymond A., Simanis V.;
RT "The S. pombe cdc16 gene is required both for maintenance of p34cdc2 kinase
RT activity and regulation of septum formation: a link between mitosis and
RT cytokinesis?";
RL EMBO J. 12:2697-2704(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP INTERACTION WITH CDC11.
RX PubMed=15062098; DOI=10.1016/j.cub.2004.03.036;
RA Morrell J.L., Tomlin G.C., Rajagopalan S., Venkatram S., Feoktistova A.S.,
RA Tasto J.J., Mehta S., Jennings J.L., Link A., Balasubramanian M.K.,
RA Gould K.L.;
RT "Sid4p-Cdc11p assembles the septation initiation network and its regulators
RT at the S. pombe SPB.";
RL Curr. Biol. 14:579-584(2004).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a dual role in the cell cycle. In mitosis, it is involved
CC in maintenance of cdc2 kinase activity. It is subsequently required for
CC regulation of septum formation. Could be involved in maintenance of
CC cdc2 kinase activity by preventing, directly or indirectly, the
CC degradation of cyclin or the dephosphorylation of 'Thr-167' of cdc2.
CC -!- INTERACTION:
CC P36618; Q10951: byr4; NbExp=6; IntAct=EBI-1997321, EBI-1997311;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole
CC body {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the BUB2 family. {ECO:0000305}.
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DR EMBL; X71605; CAA50606.1; -; Genomic_DNA.
DR EMBL; CU329670; CAB11731.1; -; Genomic_DNA.
DR PIR; S35315; S35315.
DR RefSeq; NP_593901.1; NM_001019331.2.
DR AlphaFoldDB; P36618; -.
DR SMR; P36618; -.
DR BioGRID; 278638; 42.
DR IntAct; P36618; 2.
DR STRING; 4896.SPAC6F6.08c.1; -.
DR iPTMnet; P36618; -.
DR PaxDb; P36618; -.
DR EnsemblFungi; SPAC6F6.08c.1; SPAC6F6.08c.1:pep; SPAC6F6.08c.
DR GeneID; 2542162; -.
DR KEGG; spo:SPAC6F6.08c; -.
DR PomBase; SPAC6F6.08c; cdc16.
DR VEuPathDB; FungiDB:SPAC6F6.08c; -.
DR eggNOG; KOG2058; Eukaryota.
DR HOGENOM; CLU_029367_2_0_1; -.
DR InParanoid; P36618; -.
DR OMA; RVNGWQS; -.
DR PhylomeDB; P36618; -.
DR PRO; PR:P36618; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:1990334; C:Bfa1-Bub2 complex; IPI:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0044732; C:mitotic spindle pole body; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0071957; C:old mitotic spindle pole body; IDA:PomBase.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0010974; P:negative regulation of division septum assembly; IMP:PomBase.
DR GO; GO:0031030; P:negative regulation of septation initiation signaling; IGI:PomBase.
DR InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47923; SSF47923; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..299
FT /note="Cell division control protein 16"
FT /id="PRO_0000208009"
FT DOMAIN 41..223
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
SQ SEQUENCE 299 AA; 33989 MW; 8958846E4032766D CRC64;
MPSIDCKRLQ KLAPKSPENQ SKCISRLRYM VMLDQVESDE GGNSSTRPYV WAVLLNAPPR
NADEYIRYVR QGPSPMAQKI QNDVSRTLVV ESQFHSRVSQ SSLSRLLNAY VWKRGALYVQ
GMNVLASPFL YACKSENQAF QFFDRLLQNE CPLYVLPNID GVHRGAKLLD KCLEVLDHRL
YTYLLSKGLT AKIYALPSIL TLSACTAPLS EALTIWDFLF AYGIHLNILC VIAQMFIFRE
QLIDHPSPMT LLRTFPPLNA KNIMKITILL ISKLPPELYN LLARHAWDSE AGVLIDRLT
