CDC23_ARATH
ID CDC23_ARATH Reviewed; 579 AA.
AC Q9STS3; Q570L3; Q93ZW8;
DT 10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 149.
DE RecName: Full=Anaphase-promoting complex subunit 8;
DE AltName: Full=Cell division cycle protein 23 homolog;
DE Short=CDC23 homolog;
DE AltName: Full=Cyclosome subunit 8;
GN Name=APC8; Synonyms=CDC23; OrderedLocusNames=At3g48150; ORFNames=T24C20.30;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 405-579.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INTERACTION WITH APC2.
RX PubMed=14508008; DOI=10.1105/tpc.013847;
RA Capron A., Serralbo O., Fulop K., Frugier F., Parmentier Y., Dong A.,
RA Lecureuil A., Guerche P., Kondorosi E., Scheres B., Genschik P.;
RT "The Arabidopsis anaphase-promoting complex or cyclosome: molecular and
RT genetic characterization of the APC2 subunit.";
RL Plant Cell 15:2370-2382(2003).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. The APC/C complex controls several key steps in the cell cycle
CC by mediating ubiquitination and subsequent degradation of target
CC proteins such as cyclins. The APC/C complex is required for the female
CC gametophyte development and is involved in several aspect of
CC development by controlling cell division and cell elongation. Involved
CC in the control of endoreduplication.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: The APC/C is composed of at least 10 subunits. Interacts with
CC APC2. {ECO:0000269|PubMed:14508008}.
CC -!- INTERACTION:
CC Q9STS3; Q8H1U5: APC2; NbExp=3; IntAct=EBI-2130714, EBI-1749410;
CC Q9STS3; Q84MB2: TIFY8; NbExp=3; IntAct=EBI-2130714, EBI-4426557;
CC Q9STS3; Q5CCK4: VAL2; NbExp=3; IntAct=EBI-2130714, EBI-15193683;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the APC8/CDC23 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAD93779.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL096856; CAB51062.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78373.1; -; Genomic_DNA.
DR EMBL; AY056217; AAL07066.1; -; mRNA.
DR EMBL; AY057562; AAL09801.1; -; mRNA.
DR EMBL; AY099779; AAM20630.1; -; mRNA.
DR EMBL; BT000289; AAN15608.1; -; mRNA.
DR EMBL; AK220695; BAD93779.1; ALT_INIT; mRNA.
DR PIR; T13004; T13004.
DR RefSeq; NP_190398.1; NM_114684.5.
DR AlphaFoldDB; Q9STS3; -.
DR SMR; Q9STS3; -.
DR BioGRID; 9289; 87.
DR IntAct; Q9STS3; 88.
DR STRING; 3702.AT3G48150.1; -.
DR iPTMnet; Q9STS3; -.
DR PaxDb; Q9STS3; -.
DR PRIDE; Q9STS3; -.
DR ProteomicsDB; 220521; -.
DR EnsemblPlants; AT3G48150.1; AT3G48150.1; AT3G48150.
DR GeneID; 823970; -.
DR Gramene; AT3G48150.1; AT3G48150.1; AT3G48150.
DR KEGG; ath:AT3G48150; -.
DR Araport; AT3G48150; -.
DR TAIR; locus:2100439; AT3G48150.
DR eggNOG; KOG1155; Eukaryota.
DR HOGENOM; CLU_018320_4_0_1; -.
DR InParanoid; Q9STS3; -.
DR OMA; PKYLAAW; -.
DR OrthoDB; 761109at2759; -.
DR PhylomeDB; Q9STS3; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9STS3; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9STS3; baseline and differential.
DR Genevisible; Q9STS3; AT.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IBA:GO_Central.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0031347; P:regulation of defense response; IMP:TAIR.
DR Gene3D; 1.25.40.10; -; 2.
DR InterPro; IPR007192; APC8.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF04049; ANAPC8; 1.
DR Pfam; PF13176; TPR_7; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 6.
DR SUPFAM; SSF48452; SSF48452; 2.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome; Repeat;
KW TPR repeat; Ubl conjugation pathway.
FT CHAIN 1..579
FT /note="Anaphase-promoting complex subunit 8"
FT /id="PRO_0000396845"
FT REPEAT 237..270
FT /note="TPR 1"
FT REPEAT 272..304
FT /note="TPR 2"
FT REPEAT 339..372
FT /note="TPR 3"
FT REPEAT 374..406
FT /note="TPR 4"
FT REPEAT 408..440
FT /note="TPR 5"
FT REPEAT 442..476
FT /note="TPR 6"
FT REPEAT 477..510
FT /note="TPR 7"
FT REPEAT 518..551
FT /note="TPR 8"
FT CONFLICT 141
FT /note="E -> G (in Ref. 3; AAL07066)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 579 AA; 67135 MW; 6828C7C71A44BE71 CRC64;
MVSKECCRNE IRAAIRQLSD RCLYSAAKWA GEQLVGIEQD PSNFTPANTR FQRGSSSIRR
RFSTNESIST PLPSVGFSQA ATPLPEEDEA IDGDIYLLAK SYFDCREYRR ASHMLRDQVS
KKSLFLRYYA LYLAGEKRKE EEMIELEGPL GKSDAINREL VSLERDLSAL RRTGAIDSFG
LYLYGVVLKE KGNESLARAS LVESVNSYPW NWSAWSELQS LCTSIEILNS LNLNNHWMKE
FFLGNAYQEL RMHTESLAKY EYLQGIFSFS NYIQAQTAKA QYSLREFDQV EIMFEELLRN
DPYRVEDMDL YSNVLYAKEA CAALSYLAHK VFLTDKYRPE SCCIIGNYYS LKGQHEKAVM
YFRRALKLNK KYLSAWTLMG HEYVEMKNTP AAIDAYRRAV DINPTDYRAW YGLGQAYEMM
GMPFYALHYF RKSIFFLPND SRLWIAMAKC YQTEQLYMLE EAIKCYKRAV NCTDTEGIAL
NQLAKLHQKL GRNEEAAYYF EKDLERMDAE GLEGPNMFEA LVFLATHFKN HKKFEEAEVY
CTRLLDYSGP EKEKAKSLLR GIRMAQTGFP SMDLEHFPI
