CDC23_DICDI
ID CDC23_DICDI Reviewed; 592 AA.
AC Q86B11; Q558V4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Anaphase-promoting complex subunit 8;
DE Short=APC8;
DE AltName: Full=Cell division cycle protein 23 homolog;
GN Name=anapc8; Synonyms=apc8, cdc23; ORFNames=DDB_G0272775;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: The APC/C is composed of at least 13 subunits that stay
CC tightly associated throughout the cell cycle: anapc1, anapc2, anapc3,
CC anapc4, anapc5, anapc6, anapc7, anapc8, anapc10, anapc11, cdc20, cdc26
CC and cdh1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the APC8/CDC23 family. {ECO:0000305}.
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DR EMBL; AAFI02000008; EAL71025.1; -; Genomic_DNA.
DR RefSeq; XP_644962.1; XM_639870.1.
DR AlphaFoldDB; Q86B11; -.
DR SMR; Q86B11; -.
DR STRING; 44689.DDB0266418; -.
DR PaxDb; Q86B11; -.
DR EnsemblProtists; EAL71025; EAL71025; DDB_G0272775.
DR GeneID; 8618640; -.
DR KEGG; ddi:DDB_G0272775; -.
DR dictyBase; DDB_G0272775; anapc8.
DR eggNOG; KOG1155; Eukaryota.
DR HOGENOM; CLU_018320_4_0_1; -.
DR InParanoid; Q86B11; -.
DR OMA; EHDMALE; -.
DR PhylomeDB; Q86B11; -.
DR Reactome; R-DDI-141430; Inactivation of APC/C via direct inhibition of the APC/C complex.
DR Reactome; R-DDI-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
DR Reactome; R-DDI-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR Reactome; R-DDI-174154; APC/C:Cdc20 mediated degradation of Securin.
DR Reactome; R-DDI-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR Reactome; R-DDI-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR Reactome; R-DDI-176407; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
DR Reactome; R-DDI-176408; Regulation of APC/C activators between G1/S and early anaphase.
DR Reactome; R-DDI-176409; APC/C:Cdc20 mediated degradation of mitotic proteins.
DR Reactome; R-DDI-176412; Phosphorylation of the APC/C.
DR Reactome; R-DDI-179409; APC-Cdc20 mediated degradation of Nek2A.
DR Reactome; R-DDI-2467813; Separation of Sister Chromatids.
DR Reactome; R-DDI-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR Reactome; R-DDI-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q86B11; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005680; C:anaphase-promoting complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IBA:GO_Central.
DR GO; GO:0007091; P:metaphase/anaphase transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0045842; P:positive regulation of mitotic metaphase/anaphase transition; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR007192; APC8.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF04049; ANAPC8; 1.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 6.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Mitosis; Nucleus; Reference proteome; Repeat;
KW TPR repeat; Ubl conjugation pathway.
FT CHAIN 1..592
FT /note="Anaphase-promoting complex subunit 8"
FT /id="PRO_0000328556"
FT REPEAT 66..99
FT /note="TPR 1"
FT REPEAT 160..193
FT /note="TPR 2"
FT REPEAT 291..324
FT /note="TPR 3"
FT REPEAT 359..392
FT /note="TPR 4"
FT REPEAT 393..426
FT /note="TPR 5"
FT REPEAT 428..460
FT /note="TPR 6"
FT REPEAT 461..494
FT /note="TPR 7"
FT REPEAT 496..528
FT /note="TPR 8"
FT REGION 129..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 592 AA; 69874 MW; B58FFCA61A368E58 CRC64;
MSQIKIELIK SINDLNSRGL LLSSKWSSEQ LNGLSPTILA TPLTNEEQLS IISQPSISSP
PIGSNEYYKY ILAKNYFDLK EYRRCSDVLI DCNKYQLPIF LRSYATYLAI EKRREEDIIE
QQAQQQQQQQ QAQQQAQQAQ QESQQNDKNN DTNNNNKTDQ QQQQQQQQKI EQCQEFKQLF
QFYKKLYIEN KKDMDGFLLY FYSMLLKKQR DFTMARKVLI ESVHKYPCNW SAWSDLSSLC
SDSADIIMQL SLPDHFMKDF FLAHFKLELQ QNNESLVIYQ QLSRTLFTQS TYILAQTAIG
NYNLRAYDIG EELFERLIEL EPNRLENIDI YSNILYVRDK KASLSMLAHK AMKIEKYCPE
TCCIIGNYYS LKLEHDKAIL YFQRALKLND RYLSAWTLIG HEFLEIKNVS AAINAYRKAV
DINPRDYRAW YGLGQTYQLL KLPLYSLYYF KKATTLRPYD PRMWCAAGGC YEFIERIPEA
IKCYERAEEN YDRERVAINK LAKLYQEIQN NEKAAFYYKK NLYYCDQEKI DGQEIIDALL
FLANFYKNQN QTQSEQYCLR LLDYAGPEKE EAKSILREIH SKSKLSSKSK PK
