CDC24_SCHPO
ID CDC24_SCHPO Reviewed; 501 AA.
AC O75004;
DT 16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Cell division control protein 24;
GN Name=cdc24; ORFNames=SPAC8F11.07c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=972 / ATCC 24843;
RX PubMed=9649516; DOI=10.1093/genetics/149.3.1221;
RA Gould K.L., Burns C.G., Feoktistova A., Hu C.-P., Pasion S.G.,
RA Forsburg S.L.;
RT "Fission yeast cdc24(+) encodes a novel replication factor required for
RT chromosome integrity.";
RL Genetics 149:1221-1233(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INTERACTION WITH PNC1 AND RFC1.
RX PubMed=9891039; DOI=10.1128/mcb.19.2.1038;
RA Tanaka H., Tanaka K., Murakami H., Okayama H.;
RT "Fission yeast cdc24 is a replication factor C- and proliferating cell
RT nuclear antigen-interacting factor essential for S-phase completion.";
RL Mol. Cell. Biol. 19:1038-1048(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [4]
RP FUNCTION, AND INTERACTION WITH DNA2.
RX PubMed=15576681; DOI=10.1093/nar/gkh963;
RA Tanaka H., Ryu G.H., Seo Y.S., MacNeill S.A.;
RT "Genetics of lagging strand DNA synthesis and maturation in fission yeast:
RT suppression analysis links the Dna2-Cdc24 complex to DNA polymerase
RT delta.";
RL Nucleic Acids Res. 32:6367-6377(2004).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Has a role in the progression of DNA replication and in the
CC maintenance of genomic integrity. Acts during S phase, after
CC initiation, where it is essential for completion.
CC {ECO:0000269|PubMed:15576681, ECO:0000269|PubMed:9649516,
CC ECO:0000269|PubMed:9891039}.
CC -!- SUBUNIT: Interacts with dna2, pcn1 and rfc1.
CC {ECO:0000269|PubMed:15576681, ECO:0000269|PubMed:9891039}.
CC -!- INTERACTION:
CC O75004; Q9URU2: dna2; NbExp=3; IntAct=EBI-1559355, EBI-16120355;
CC O75004; Q9UUA8: SPBC409.16c; NbExp=2; IntAct=EBI-1559355, EBI-16120313;
CC O75004; O94542: SPCC1322.02; NbExp=6; IntAct=EBI-1559355, EBI-16120253;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}. Cytoplasm
CC {ECO:0000269|PubMed:16823372}. Cell septum
CC {ECO:0000269|PubMed:16823372}.
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DR EMBL; AF085329; AAC34684.1; -; Genomic_DNA.
DR EMBL; AB015436; BAA28896.1; -; mRNA.
DR EMBL; CU329670; CAB52168.1; -; Genomic_DNA.
DR PIR; T43375; T43375.
DR RefSeq; NP_593956.1; NM_001019383.2.
DR AlphaFoldDB; O75004; -.
DR BioGRID; 279829; 26.
DR DIP; DIP-39146N; -.
DR IntAct; O75004; 6.
DR MINT; O75004; -.
DR STRING; 4896.SPAC8F11.07c.1; -.
DR MaxQB; O75004; -.
DR PaxDb; O75004; -.
DR EnsemblFungi; SPAC8F11.07c.1; SPAC8F11.07c.1:pep; SPAC8F11.07c.
DR GeneID; 2543407; -.
DR KEGG; spo:SPAC8F11.07c; -.
DR PomBase; SPAC8F11.07c; cdc24.
DR VEuPathDB; FungiDB:SPAC8F11.07c; -.
DR HOGENOM; CLU_551139_0_0_1; -.
DR OMA; YHEDRFS; -.
DR PRO; PR:O75004; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0032153; C:cell division site; HDA:PomBase.
DR GO; GO:0030428; C:cell septum; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0043596; C:nuclear replication fork; IC:PomBase.
DR GO; GO:0005654; C:nucleoplasm; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0035861; C:site of double-strand break; IDA:PomBase.
DR GO; GO:0000729; P:DNA double-strand break processing; IMP:PomBase.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; EXP:PomBase.
DR GO; GO:1903461; P:Okazaki fragment processing involved in mitotic DNA replication; IPI:PomBase.
DR InterPro; IPR035201; Cdc24_OB1.
DR InterPro; IPR035200; Cdc24_OB2.
DR InterPro; IPR035203; Cdc24_OB3.
DR Pfam; PF17246; CDC24_OB1; 1.
DR Pfam; PF17245; CDC24_OB2; 1.
DR Pfam; PF17244; CDC24_OB3; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..501
FT /note="Cell division control protein 24"
FT /id="PRO_0000089445"
SQ SEQUENCE 501 AA; 58043 MW; 66E84CCB46244863 CRC64;
MDFPGLIKKI KEDLENRLVE KSKQPAFTDY WLINKTISLL KEYPSGFSYP ILINEIELAC
SERNKLDNVF SSLEWLTKSD AVIYLEDQFH FHCYDYYYTP IPSLKLKDSE ENTCEMILHS
SFYLLFHEPF NILKGSTLRF SQSRIHQKWY LRKQIRFLPT TSFVPVLQYA ASKSFVKSMV
ESTEHEFFQI RDITISKSDQ GVKRITVELG RIISLDKKGA FLIDNNTNFI HFSGTYHDFP
KLLDKQQYLL IPFWSTVWEG STNWQDGMIG ILVILSENDF EEKKCDSWQV GRLAAVNSNF
LVLDNNGQRV KILYSNSQKH YFKDTYIGDL LCISPINHSS DNLSDYSCVS DTTTEILSNL
ENPLSSNFLR NDLCKFSNLF SGVSGHLKIQ PLTLVITGFV ANLTRQSDLN TSLVLPEVNP
LTAKMEVIDC LRNSFWAALR PNCVSYFASM ISGFKELFQK EMEFPIYLDL KSYKLGFHWC
DIYVDSEHNC HIQKINSLPC E
