CDC25_CANAL
ID CDC25_CANAL Reviewed; 1333 AA.
AC P43069; A0A1D8PJT3; Q59SU3;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Cell division control protein 25;
GN Name=CDC25; Synonyms=CSC25; OrderedLocusNames=CAALFM_C303890WA;
GN ORFNames=CaO19.14188, CaO19.6926;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=792-1;
RX PubMed=8477693; DOI=10.1111/j.1432-1033.1993.tb17748.x;
RA Goldberg D., Marbach I., Gross E., Levitzki A., Simchen G.;
RT "A Candida albicans homolog of CDC25 is functional in Saccharomyces
RT cerevisiae.";
RL Eur. J. Biochem. 213:195-204(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Promotes the exchange of Ras-bound GDP by GTP. This protein
CC positively controls the level of cellular cAMP at start, the stage at
CC which the yeast cell division cycle is triggered.
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DR EMBL; M94160; AAA34329.2; -; Genomic_DNA.
DR EMBL; CP017625; AOW28416.1; -; Genomic_DNA.
DR PIR; S30356; S30356.
DR RefSeq; XP_712727.2; XM_707634.2.
DR AlphaFoldDB; P43069; -.
DR SMR; P43069; -.
DR BioGRID; 1228753; 2.
DR STRING; 237561.P43069; -.
DR PRIDE; P43069; -.
DR GeneID; 3645660; -.
DR KEGG; cal:CAALFM_C303890WA; -.
DR CGD; CAL0000178834; CSC25.
DR VEuPathDB; FungiDB:C3_03890W_A; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002171_1_0_1; -.
DR InParanoid; P43069; -.
DR OMA; PFVFCSM; -.
DR OrthoDB; 98339at2759; -.
DR PRO; PR:P43069; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:CGD.
DR GO; GO:0019933; P:cAMP-mediated signaling; IMP:CGD.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0071333; P:cellular response to glucose stimulus; IMP:CGD.
DR GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IGI:CGD.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; -; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23113; PTHR23113; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48366; SSF48366; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Cell cycle; Cell division; Guanine-nucleotide releasing factor; Mitosis;
KW Reference proteome; SH3 domain.
FT CHAIN 1..1333
FT /note="Cell division control protein 25"
FT /id="PRO_0000068861"
FT DOMAIN 30..94
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 900..1034
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT DOMAIN 1068..1305
FT /note="Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 198
FT /note="L -> P (in Ref. 1; AAA34329)"
FT /evidence="ECO:0000305"
FT CONFLICT 1308..1309
FT /note="AV -> PA (in Ref. 1; AAA34329)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1333 AA; 152031 MW; 77AE469FF95834C2 CRC64;
MSSANYISDE VPPDMVSPHD HRPSKDEPLK HLDTVIALYD FPGTQSSHLP LNLGDTIHVL
SKSATGWWDG VVMGNSGELQ RGWFPHNYVR SVNYVQPVLK KLKDNKDLDS ITAANTAANV
VMPSLTNLIQ KSLQESERNS PANSTRKNSV VSFASSETSM PSDSKYTQQQ TNTNQNSPEY
QSISLPSTRD HSTVEMQLPS QQSSISHTLT GFGIGDDEII PMEVEEAEKL VEEYRLKYNK
TVTWIPRTST KGDIIFYCEQ LDVYCESLPL ILFDGEASSP NLEYPGSDVI MDPTPISVQG
SQSMENVLDT REGSAAGSFD STKRDSNVSM STQSSGSSYH RFSRPFFSVD NLFYKHSSDI
GTWNELKEQC NYILDLMLKA IKDQNRQFFS THFSRLNKLV VALCAAVRLN QEDYIDTKYE
NTTRRKLKRV CASFAQIYIN GILHLSVLHY SLEGFNEGRL FGYDMGKLNR SSSSSAFQSP
ASSLSTIRQG SDDSTRFAQK LSQDRNSEGN GDMNYINQLV YEIDNLRENV NSIVKIFLKL
SANKKIKNSD YDSSDASDDE GEDRFDILPQ VYPRFLVDEF NGGNWCNPFF STKNTVLNVS
GDDLKNRYHT KIIIDHSAYD SLSQYVDKIV DACENILEAL DPKVQNTFYY NEMLRNERNT
QILRLTYKSL YHCSAMVDLI ESFDFTVFCS VKRHTGNAID TEDESYENPS VWGDHYDSNL
SFDYPVVLEF FRLKQELHDL VAKIIMATQS LTLEDPEVFK GLKEEDPLFY NREISKIPKE
KAALLLSSIL KEQLSFKDGG AISLNPDTLL SGYLVEIAKT TKTVLLITQQ LIEERETIIN
YATRVMQDNF DVQLLLVERN NTSSSEKADD NSYYVGGHKK STDVPWYLEG DDEYELLLDV
KGNIKGGSKE ALVSHLTHHL SLDSNFNAVF LLMFSSMMSL GELISLLIAR FNIEPPEGLS
YEEYNLWVSK KRNPIRLRVI NIMKLLLEKN WSMSYYNEPV LRRWLTFAHS DQVQTYSLGN
LLVNYLERLL RGERIYVERD PVIPNTKPPA PLTKGSSLSK KPRVMDIDYV ELARQLTLRE
FKLYCKITKF ACLAKVWGKK SGLSESIDSI TQFIKASNQL TNFVGYMILR KADPKKRVQI
IRYFIQVADK CRQYNNFSSM TAIISALYSS PIHRLKKTWE YMNADALSNL KNMNKLMNSS
RNFNEYRDVL KFIGSEPCVP FFGVYLSDLT FVYHGNPDYL YNRTRQVNFA KRAKTSEIVS
GIDRFKTTGY NFQEVPEIQK FLDAWFEKCP TIDEQYQISL NLEPREQAVG ASNSNSTTNA
TTNIKSFKPF SLK
