CDC26_CAEEL
ID CDC26_CAEEL Reviewed; 194 AA.
AC G4RT11; A9D8E6; G4RT06; H2KYB5;
DT 20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 2.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Anaphase-promoting complex subunit CDC26 {ECO:0000250|UniProtKB:Q8NHZ8};
DE AltName: Full=Cell division cycle protein 26 homolog {ECO:0000250|UniProtKB:Q8NHZ8};
GN Name=cdc-26 {ECO:0000312|WormBase:B0511.9c};
GN Synonyms=mat-4 {ECO:0000312|WormBase:B0511.9c},
GN tag-265 {ECO:0000312|WormBase:B0511.9c};
GN ORFNames=B0511.9 {ECO:0000312|WormBase:B0511.9c};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17374146; DOI=10.1186/1471-213x-7-19;
RA Dong Y., Bogdanova A., Habermann B., Zachariae W., Ahringer J.;
RT "Identification of the C. elegans anaphase promoting complex subunit Cdc26
RT by phenotypic profiling and functional rescue in yeast.";
RL BMC Dev. Biol. 7:19-19(2007).
CC -!- FUNCTION: Probable component of the anaphase promoting
CC complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase
CC that controls progression through mitosis and the G1 phase of the cell
CC cycle. The APC/C complex acts by mediating ubiquitination and
CC subsequent degradation of target proteins. Developmental role in early
CC embryogenesis and the metaphase to anaphase transition in meiosis and
CC mitosis. Required for embryonic anterior-posterior axis formation.
CC {ECO:0000269|PubMed:17374146}.
CC -!- PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305}.
CC -!- SUBUNIT: The APC/C complex is probably composed of at least 12
CC subunits: apc-2, apc-10, apc-11, cdc-26, emb-1, emb-27, emb-30, mat-1,
CC mat-2, mat-3, such-1 and gfi-3. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P14724}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=c {ECO:0000312|WormBase:B0511.9c};
CC IsoId=G4RT11-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:B0511.9a};
CC IsoId=G4RT11-2; Sequence=VSP_058039;
CC Name=b {ECO:0000312|WormBase:B0511.9b};
CC IsoId=G4RT11-3; Sequence=VSP_058038, VSP_058040, VSP_058041;
CC Name=d {ECO:0000312|WormBase:B0511.9d};
CC IsoId=G4RT11-4; Sequence=VSP_058037, VSP_058038, VSP_058039;
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in arrest at
CC metaphase during meiosis I in early embryos. Defective embryonic
CC polarity due to improper first cell division.
CC {ECO:0000269|PubMed:17374146}.
CC -!- SIMILARITY: Belongs to the CDC26 family. {ECO:0000305}.
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DR EMBL; BX284601; CCD62107.1; -; Genomic_DNA.
DR EMBL; BX284601; CCD62110.1; -; Genomic_DNA.
DR EMBL; BX284601; CCD62111.1; -; Genomic_DNA.
DR EMBL; BX284601; CCD62112.1; -; Genomic_DNA.
DR RefSeq; NP_001251445.1; NM_001264516.1. [G4RT11-4]
DR RefSeq; NP_001251447.1; NM_001264518.1. [G4RT11-1]
DR RefSeq; NP_740913.3; NM_170919.4. [G4RT11-2]
DR RefSeq; NP_740914.2; NM_171844.4. [G4RT11-3]
DR AlphaFoldDB; G4RT11; -.
DR ComplexPortal; CPX-3382; Anaphase Promoting Complex/Cyclosome.
DR DIP; DIP-26086N; -.
DR IntAct; G4RT11; 4.
DR STRING; 6239.B0511.9c; -.
DR EPD; G4RT11; -.
DR PaxDb; G4RT11; -.
DR PeptideAtlas; G4RT11; -.
DR EnsemblMetazoa; B0511.9a.1; B0511.9a.1; WBGene00015235. [G4RT11-2]
DR EnsemblMetazoa; B0511.9b.1; B0511.9b.1; WBGene00015235. [G4RT11-3]
DR EnsemblMetazoa; B0511.9c.1; B0511.9c.1; WBGene00015235. [G4RT11-1]
DR EnsemblMetazoa; B0511.9d.1; B0511.9d.1; WBGene00015235. [G4RT11-4]
DR GeneID; 172958; -.
DR KEGG; cel:CELE_B0511.9; -.
DR UCSC; B0511.9b; c. elegans.
DR CTD; 172958; -.
DR WormBase; B0511.9a; CE44875; WBGene00015235; cdc-26. [G4RT11-2]
DR WormBase; B0511.9b; CE41861; WBGene00015235; cdc-26. [G4RT11-3]
DR WormBase; B0511.9c; CE26854; WBGene00015235; cdc-26. [G4RT11-1]
DR WormBase; B0511.9d; CE46530; WBGene00015235; cdc-26. [G4RT11-4]
DR eggNOG; ENOG502TEJ1; Eukaryota.
DR InParanoid; G4RT11; -.
DR OMA; ECTRTSI; -.
DR OrthoDB; 1820518at2759; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:G4RT11; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00015235; Expressed in embryo and 4 other tissues.
DR GO; GO:0005680; C:anaphase-promoting complex; IC:ComplexPortal.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IC:ComplexPortal.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0051445; P:regulation of meiotic cell cycle; IC:ComplexPortal.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IC:ComplexPortal.
DR GO; GO:1904666; P:regulation of ubiquitin protein ligase activity; IC:ComplexPortal.
PE 3: Inferred from homology;
KW Alternative splicing; Cell cycle; Cell division; Developmental protein;
KW Meiosis; Mitosis; Nucleus; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..194
FT /note="Anaphase-promoting complex subunit CDC26"
FT /evidence="ECO:0000305"
FT /id="PRO_0000435331"
FT REGION 47..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..74
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 14..32
FT /note="CEDDIQWLTDQLNKRVLPA -> S (in isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_058037"
FT VAR_SEQ 88
FT /note="P -> PNRCEMSFTEVQ (in isoform b and isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_058038"
FT VAR_SEQ 172
FT /note="Missing (in isoform a and isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_058039"
FT VAR_SEQ 173..174
FT /note="AT -> GQ (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_058040"
FT VAR_SEQ 175..194
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_058041"
SQ SEQUENCE 194 AA; 21195 MW; 30DECBAEA18F263A CRC64;
MSMLRRPLTQ LELCEDDIQW LTDQLNKRVL PAVIVPKCEM MDIDEMEPMD QSEPPRGITR
RNLRSADRKN RDVPGPSTGE CTRTSIAPTL TSARTPVAAP TLTLSTPVNP VSSAEMLRVM
PPRVGRRPRA SRSGDNDSPL LFNAYDTPQQ GINDESPTPS DSPESPNAHL YGATPGNPTS
TSGGPSSNTR SHRH
