CDC26_DANRE
ID CDC26_DANRE Reviewed; 88 AA.
AC Q68EK9; A2CES9;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Anaphase-promoting complex subunit CDC26;
DE AltName: Full=Cell division cycle protein 26 homolog;
GN Name=cdc26; ORFNames=si:dkey-190c14.5, zgc:100965;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=TL;
RX PubMed=17141209; DOI=10.1016/j.ydbio.2006.10.043;
RA Wehman A.M., Staub W., Baier H.;
RT "The anaphase-promoting complex is required in both dividing and quiescent
RT cells during zebrafish development.";
RL Dev. Biol. 303:144-156(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle. The
CC APC/C complex acts by mediating ubiquitination and subsequent
CC degradation of target proteins: it mainly mediates the formation of
CC 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By
CC similarity). May recruit the E2 ubiquitin-conjugating enzymes to the
CC complex. {ECO:0000250, ECO:0000269|PubMed:17141209}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: The APC/C is composed of at least 12 subunits. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CDC26 family. {ECO:0000305}.
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DR EMBL; DQ352177; ABD22986.1; -; mRNA.
DR EMBL; CR759821; CAM15227.1; -; Genomic_DNA.
DR EMBL; BC080217; AAH80217.1; -; mRNA.
DR RefSeq; NP_001004005.1; NM_001004005.2.
DR RefSeq; XP_017211560.1; XM_017356071.1.
DR AlphaFoldDB; Q68EK9; -.
DR SMR; Q68EK9; -.
DR STRING; 7955.ENSDARP00000100739; -.
DR PaxDb; Q68EK9; -.
DR Ensembl; ENSDART00000112793; ENSDARP00000100739; ENSDARG00000077815.
DR Ensembl; ENSDART00000183470; ENSDARP00000155045; ENSDARG00000115575.
DR GeneID; 445501; -.
DR KEGG; dre:445501; -.
DR CTD; 246184; -.
DR ZFIN; ZDB-GENE-040822-18; cdc26.
DR eggNOG; ENOG502S5GK; Eukaryota.
DR GeneTree; ENSGT00390000008457; -.
DR HOGENOM; CLU_190086_0_0_1; -.
DR InParanoid; Q68EK9; -.
DR OMA; HKSREQM; -.
DR OrthoDB; 1612963at2759; -.
DR PhylomeDB; Q68EK9; -.
DR TreeFam; TF101057; -.
DR Reactome; R-DRE-141430; Inactivation of APC/C via direct inhibition of the APC/C complex.
DR Reactome; R-DRE-174048; APC/C:Cdc20 mediated degradation of Cyclin B.
DR Reactome; R-DRE-174084; Autodegradation of Cdh1 by Cdh1:APC/C.
DR Reactome; R-DRE-174154; APC/C:Cdc20 mediated degradation of Securin.
DR Reactome; R-DRE-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1.
DR Reactome; R-DRE-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A.
DR Reactome; R-DRE-176407; Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase.
DR Reactome; R-DRE-176408; Regulation of APC/C activators between G1/S and early anaphase.
DR Reactome; R-DRE-176412; Phosphorylation of the APC/C.
DR Reactome; R-DRE-179409; APC-Cdc20 mediated degradation of Nek2A.
DR Reactome; R-DRE-2467813; Separation of Sister Chromatids.
DR Reactome; R-DRE-2559582; Senescence-Associated Secretory Phenotype (SASP).
DR Reactome; R-DRE-68867; Assembly of the pre-replicative complex.
DR Reactome; R-DRE-69017; CDK-mediated phosphorylation and removal of Cdc6.
DR Reactome; R-DRE-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q68EK9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000077815; Expressed in gastrula and 23 other tissues.
DR GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000278; P:mitotic cell cycle; IMP:ZFIN.
DR GO; GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
DR GO; GO:0007346; P:regulation of mitotic cell cycle; IMP:ZFIN.
DR GO; GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:InterPro.
DR InterPro; IPR018860; APC_suCDC26.
DR PANTHER; PTHR28579; PTHR28579; 1.
DR Pfam; PF10471; ANAPC_CDC26; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Mitosis; Nucleus;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..88
FT /note="Anaphase-promoting complex subunit CDC26"
FT /id="PRO_0000271351"
FT REGION 17..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 69..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 7..37
FT /evidence="ECO:0000255"
SQ SEQUENCE 88 AA; 9942 MW; 7C1FD9083E392CE4 CRC64;
MLRRKPTRLE LKLDDTEEFE SVKKELESRK KQRDEVDVVG VATSSEMSGA AGGTADGKTR
EQMIHERIGY KPHPKPNTLP SLFGNLQF
