ID   CDC26_PONAB             Reviewed;          85 AA.
AC   Q5RAQ7;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Anaphase-promoting complex subunit CDC26;
DE   AltName: Full=Cell division cycle protein 26 homolog;
GN   Name=CDC26;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC       (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC       progression through mitosis and the G1 phase of the cell cycle. The
CC       APC/C complex acts by mediating ubiquitination and subsequent
CC       degradation of target proteins: it mainly mediates the formation of
CC       'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC       formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May
CC       recruit the E2 ubiquitin-conjugating enzymes to the complex (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: V-shaped homodimer. Interacts with CDC16. The mammalian APC/C
CC       is composed at least of 14 distinct subunits ANAPC1, ANAPC2,
CC       CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10,
CC       ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a
CC       complex of at least 19 chains with a combined molecular mass of around
CC       1.2 MDa; APC/C interacts with FZR1 and FBXO5.
CC       {ECO:0000250|UniProtKB:Q8NHZ8}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC26 family. {ECO:0000305}.
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DR   EMBL; CR858955; CAH91153.1; -; mRNA.
DR   RefSeq; NP_001127382.1; NM_001133910.1.
DR   AlphaFoldDB; Q5RAQ7; -.
DR   SMR; Q5RAQ7; -.
DR   STRING; 9601.ENSPPYP00000021868; -.
DR   GeneID; 100174448; -.
DR   KEGG; pon:100174448; -.
DR   CTD; 246184; -.
DR   eggNOG; ENOG502S5GK; Eukaryota.
DR   InParanoid; Q5RAQ7; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.
DR   GO; GO:0031145; P:anaphase-promoting complex-dependent catabolic process; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
DR   GO; GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IEA:InterPro.
DR   InterPro; IPR018860; APC_suCDC26.
DR   PANTHER; PTHR28579; PTHR28579; 1.
DR   Pfam; PF10471; ANAPC_CDC26; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Coiled coil; Mitosis; Nucleus; Phosphoprotein;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..85
FT                   /note="Anaphase-promoting complex subunit CDC26"
FT                   /id="PRO_0000271196"
FT   REGION          30..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          7..38
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        71..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         42
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NHZ8"
FT   MOD_RES         82
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NHZ8"
SQ   SEQUENCE   85 AA;  9776 MW;  133E70EE68F01429 CRC64;
     MLRRKPTRLE LKLDDIEEFE NIRKDLETRK KQKEDVEVVG GSDGEGAIGL SSDPKSREQM
     IIDRIGYKPQ PKPNNRSSQF GSLEF