ID   CDC37_DROVI             Reviewed;         399 AA.
AC   Q24740; B4LDG0; Q5G5F1;
DT   20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Hsp90 co-chaperone Cdc37;
DE   AltName: Full=Hsp90 chaperone protein kinase-targeting subunit;
GN   Name=Cdc37; ORFNames=GJ12421;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8020093; DOI=10.1016/0092-8674(94)90442-1;
RA   Cutforth T., Rubin G.M.;
RT   "Mutations in Hsp83 and cdc37 impair signaling by the sevenless receptor
RT   tyrosine kinase in Drosophila.";
RL   Cell 77:1027-1036(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 44-336.
RC   STRAIN=A11;
RX   PubMed=14738738; DOI=10.1016/j.cub.2003.12.055;
RA   Maside X., Lee A.W., Charlesworth B.;
RT   "Selection on codon usage in Drosophila americana.";
RL   Curr. Biol. 14:150-154(2004).
CC   -!- FUNCTION: Co-chaperone that binds to numerous kinases and promotes
CC       their interaction with the Hsp90 complex, resulting in stabilization
CC       and promotion of their activity. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a complex with Hsp90. Interacts with a number of kinases
CC       such as CDC2 and Sevenless (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC37 family. {ECO:0000305}.
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DR   EMBL; L37055; AAA50964.1; -; Genomic_DNA.
DR   EMBL; CH940647; EDW68898.1; -; Genomic_DNA.
DR   EMBL; AY849340; AAW59003.1; -; Genomic_DNA.
DR   RefSeq; XP_002046556.1; XM_002046520.2.
DR   AlphaFoldDB; Q24740; -.
DR   SMR; Q24740; -.
DR   STRING; 7244.FBpp0226838; -.
DR   PRIDE; Q24740; -.
DR   EnsemblMetazoa; FBtr0228346; FBpp0226838; FBgn0013067.
DR   GeneID; 6624466; -.
DR   KEGG; dvi:6624466; -.
DR   eggNOG; KOG2260; Eukaryota.
DR   HOGENOM; CLU_046495_0_0_1; -.
DR   InParanoid; Q24740; -.
DR   OMA; IWCINLE; -.
DR   OrthoDB; 786744at2759; -.
DR   PhylomeDB; Q24740; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005158; F:insulin receptor binding; IEA:EnsemblMetazoa.
DR   GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR   GO; GO:0046628; P:positive regulation of insulin receptor signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:EnsemblMetazoa.
DR   Gene3D; 1.20.58.610; -; 1.
DR   InterPro; IPR004918; Cdc37.
DR   InterPro; IPR013873; Cdc37_C.
DR   InterPro; IPR013874; Cdc37_Hsp90-bd.
DR   InterPro; IPR038189; Cdc37_Hsp90-bd_sf.
DR   InterPro; IPR013855; Cdc37_N_dom.
DR   PANTHER; PTHR12800; PTHR12800; 1.
DR   Pfam; PF08564; CDC37_C; 1.
DR   Pfam; PF08565; CDC37_M; 1.
DR   Pfam; PF03234; CDC37_N; 1.
DR   SMART; SM01069; CDC37_C; 1.
DR   SMART; SM01070; CDC37_M; 1.
DR   SMART; SM01071; CDC37_N; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Reference proteome.
FT   CHAIN           1..399
FT                   /note="Hsp90 co-chaperone Cdc37"
FT                   /id="PRO_0000195064"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          345..399
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..364
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..385
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   399 AA;  46573 MW;  D67C9D6328673AE7 CRC64;
     MVDYSKWKNI EISDDEDETH PNIDTPSLFR WRHQARVERM AESEKEKEEL KKKRQSYQAR
     LINVKELISK KEGDEVALKK ELEKIENEGK ELDRQENELL KREKKTPWNV DTISKPGFEK
     TVINKKPPRK AAEDLTEEER EQRMKQFVKE NEKLCKQYGM LRKYDDSKRF LQEHLDLVCE
     ETANYLVIWS INLEMEEKHD LMAHVAHQCI CMQYILELAK QLDVDPRACV SSFFSKIQQC
     VPEYRQQFES EIEGFKERIQ KRAQEKLQEA MAQLEEEEKQ ERMGPGGLDP ADVFESLPEE
     LKACFESRDI ELLQKTIATM PVDQAKYHMK RCVDSGLWVP NAADVQLGND ETEAKDDETT
     TATNETPTEK ENSKSQNEKS ADAAKEEPLY AGVSTDDVD