CDC42_DROPS
ID CDC42_DROPS Reviewed; 191 AA.
AC Q29HY3;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Cdc42 homolog;
DE EC=3.6.5.2 {ECO:0000250|UniProtKB:P60766, ECO:0000250|UniProtKB:P60953};
DE Flags: Precursor;
GN Name=Cdc42 {ECO:0000250|UniProtKB:P40793}; ORFNames=GA11680;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1] {ECO:0000312|EMBL:EAL31624.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Regulates mbt kinase activity and is also required to recruit
CC mbt to adherens junctions. Together with mbt, regulates photoreceptor
CC cell morphogenesis (By similarity). {ECO:0000250|UniProtKB:P40793}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000250|UniProtKB:P60766,
CC ECO:0000250|UniProtKB:P60953};
CC -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC {ECO:0000250|UniProtKB:P40793}. Cell membrane {ECO:0000250}; Lipid-
CC anchor {ECO:0000250|UniProtKB:P40793}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rho family. CDC42
CC subfamily. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL31624.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CH379064; EAL31624.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_001354570.1; XM_001354534.3.
DR RefSeq; XP_015041468.1; XM_015185982.1.
DR AlphaFoldDB; Q29HY3; -.
DR SMR; Q29HY3; -.
DR STRING; 7237.FBpp0285703; -.
DR EnsemblMetazoa; FBtr0287265; FBpp0285703; FBgn0071730.
DR EnsemblMetazoa; FBtr0367625; FBpp0330542; FBgn0071730.
DR GeneID; 4814629; -.
DR KEGG; dpo:Dpse_GA11680; -.
DR eggNOG; KOG0393; Eukaryota.
DR HOGENOM; CLU_041217_21_3_1; -.
DR InParanoid; Q29HY3; -.
DR OMA; ITHHQQK; -.
DR PhylomeDB; Q29HY3; -.
DR ChiTaRS; Cdc42; fly.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0071730; Expressed in female reproductive system and 2 other tissues.
DR GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR GO; GO:0045177; C:apical part of cell; IEA:EnsemblMetazoa.
DR GO; GO:0005938; C:cell cortex; IEA:EnsemblMetazoa.
DR GO; GO:0030426; C:growth cone; IEA:EnsemblMetazoa.
DR GO; GO:0030027; C:lamellipodium; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; IEA:EnsemblMetazoa.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016028; C:rhabdomere; IEA:EnsemblMetazoa.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0032794; F:GTPase activating protein binding; IEA:EnsemblMetazoa.
DR GO; GO:0019901; F:protein kinase binding; IEA:EnsemblMetazoa.
DR GO; GO:0031532; P:actin cytoskeleton reorganization; IEA:EnsemblMetazoa.
DR GO; GO:0030041; P:actin filament polymerization; IEA:EnsemblMetazoa.
DR GO; GO:0048675; P:axon extension; IEA:EnsemblMetazoa.
DR GO; GO:0035147; P:branch fusion, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0030031; P:cell projection assembly; IEA:EnsemblMetazoa.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:EnsemblMetazoa.
DR GO; GO:0048813; P:dendrite morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0046843; P:dorsal appendage formation; IEA:EnsemblMetazoa.
DR GO; GO:0007391; P:dorsal closure; IEA:EnsemblMetazoa.
DR GO; GO:0045200; P:establishment of neuroblast polarity; IEA:EnsemblMetazoa.
DR GO; GO:0051601; P:exocyst localization; IEA:EnsemblMetazoa.
DR GO; GO:0035099; P:hemocyte migration; IEA:EnsemblMetazoa.
DR GO; GO:0035318; P:imaginal disc-derived wing hair outgrowth; IEA:EnsemblMetazoa.
DR GO; GO:0030011; P:maintenance of cell polarity; IEA:EnsemblMetazoa.
DR GO; GO:0045185; P:maintenance of protein location; ISS:UniProtKB.
DR GO; GO:0035011; P:melanotic encapsulation of foreign target; IEA:EnsemblMetazoa.
DR GO; GO:0008045; P:motor neuron axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0097206; P:nephrocyte filtration; IEA:EnsemblMetazoa.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:EnsemblMetazoa.
DR GO; GO:0016318; P:ommatidial rotation; IEA:EnsemblMetazoa.
DR GO; GO:0006909; P:phagocytosis; IEA:EnsemblMetazoa.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:EnsemblMetazoa.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:EnsemblMetazoa.
DR GO; GO:0010592; P:positive regulation of lamellipodium assembly; IEA:EnsemblMetazoa.
DR GO; GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.
DR GO; GO:0090303; P:positive regulation of wound healing; IEA:EnsemblMetazoa.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0030833; P:regulation of actin filament polymerization; IEA:EnsemblMetazoa.
DR GO; GO:0050770; P:regulation of axonogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0008360; P:regulation of cell shape; IEA:EnsemblMetazoa.
DR GO; GO:0046928; P:regulation of neurotransmitter secretion; IEA:EnsemblMetazoa.
DR GO; GO:0008582; P:regulation of synaptic assembly at neuromuscular junction; IEA:EnsemblMetazoa.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:EnsemblMetazoa.
DR GO; GO:0050975; P:sensory perception of touch; IEA:EnsemblMetazoa.
DR GO; GO:0007286; P:spermatid development; IEA:EnsemblMetazoa.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0042060; P:wound healing; IEA:EnsemblMetazoa.
DR CDD; cd01874; Cdc42; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR037874; Cdc42.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072; PTHR24072; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51420; RHO; 1.
PE 3: Inferred from homology;
KW Cell junction; Cell membrane; Developmental protein; GTP-binding;
KW Hydrolase; Lipoprotein; Membrane; Methylation; Nucleotide-binding;
KW Prenylation; Reference proteome.
FT CHAIN 1..188
FT /note="Cdc42 homolog"
FT /evidence="ECO:0000250|UniProtKB:P61585"
FT /id="PRO_0000312821"
FT PROPEP 189..191
FT /note="Removed in mature form"
FT /evidence="ECO:0000250|UniProtKB:P61585"
FT /id="PRO_0000312822"
FT MOTIF 32..40
FT /note="Effector region"
FT /evidence="ECO:0000255"
FT BINDING 10..17
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P61585"
FT BINDING 57..61
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P61585"
FT BINDING 115..118
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:P61585"
FT MOD_RES 188
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250|UniProtKB:P61585"
FT LIPID 188
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250|UniProtKB:P61585"
SQ SEQUENCE 191 AA; 21390 MW; 944B6574B83D00F6 CRC64;
MQTIKCVVVG DGAVGKTCLL ISYTTNKFPS EYVPTVFDNY AVTVMIGGEP YTLGLFDTAG
QEDYDRLRPL SYPQTDVFLV CFSVVSPSSF ENVKEKWVPE ITHHCQKTPF LLVGTQIDLR
DETSTLEKLA KNKQKPITME QGEKLAKELK AVKYVECSAL TQKGLKNVFD EAILAALEPP
EPTKKRKCKF L
