ID   CDC45_DICDI             Reviewed;         644 AA.
AC   Q55GA4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Cell division control protein 45 homolog;
GN   Name=cdc45; ORFNames=DDB_G0267748;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Required for initiation of chromosomal DNA replication.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CDC45 family. {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73327.1; -; Genomic_DNA.
DR   RefSeq; XP_647280.1; XM_642188.1.
DR   AlphaFoldDB; Q55GA4; -.
DR   SMR; Q55GA4; -.
DR   STRING; 44689.DDB0237549; -.
DR   PaxDb; Q55GA4; -.
DR   EnsemblProtists; EAL73327; EAL73327; DDB_G0267748.
DR   GeneID; 8616086; -.
DR   KEGG; ddi:DDB_G0267748; -.
DR   dictyBase; DDB_G0267748; cdc45.
DR   eggNOG; KOG2475; Eukaryota.
DR   HOGENOM; CLU_005871_4_0_1; -.
DR   InParanoid; Q55GA4; -.
DR   OMA; PWNLANV; -.
DR   PhylomeDB; Q55GA4; -.
DR   Reactome; R-DDI-68962; Activation of the pre-replicative complex.
DR   PRO; PR:Q55GA4; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0031261; C:DNA replication preinitiation complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR   GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR   GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR   GO; GO:1902977; P:mitotic DNA replication preinitiation complex assembly; IBA:GO_Central.
DR   InterPro; IPR003874; CDC45.
DR   PANTHER; PTHR10507; PTHR10507; 1.
DR   Pfam; PF02724; CDC45; 1.
PE   3: Inferred from homology;
KW   Cell cycle; DNA replication; Nucleus; Reference proteome.
FT   CHAIN           1..644
FT                   /note="Cell division control protein 45 homolog"
FT                   /id="PRO_0000328571"
FT   REGION          141..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..202
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..234
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..328
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   644 AA;  74212 MW;  049A8E10FC553D30 CRC64;
     MVLTTDTKFS EIYDIIKGDS VQGESVLILV ARDCDSIAAC KILTEILKSD LIAYNIKAVS
     GYEDLENVNS TLLENEEIKS IIMINCGGNI DITNVFTNLN DQQVAYIIDS HRPYSINNIT
     NESSVLIIDD GTYIEQDELQ QLSDDSEEEE EELEEEEAEE DVVEDEAEEA EEAEEAEEAE
     EAEFDPENED NPENDEDDGG SENIDENERK SKKKNKKDKK SKRKHRKKKK KKSEKLEKTY
     YGKSAAVSMY SLSTFLNKQN LDDLLWYAVL GLTDQFIHEK ITLDSYEQQY KNFKELILNN
     YPTDGDDDQE ERYRPGNDED DYDENGDLKR HPSSMFLHGD KIIPSDDFRF MLYRHWNLYE
     SLFNSRYVAC KLRVWKAKGR FQLESLFAMM GIPLDQVKQK YNSMNVHYKK QLKQLLAING
     PKFGLVNLYF NSFLKKYSNN SEISASDTVY AVTALMESDN LESDQSDQDI WEQNFWEAYD
     SISNKNIDLL KIGLKQSIQL QKEITRQVTS MIEKRSVILS GPFRYAFITE SSDLKYFIHP
     LALTKLGLFM MDAFISMGKA KRPFLIGALN ENKNSYLIVG ISGSHSTDIQ SNTFGEYFRK
     SAEYTDATFK YQSFDTSIVE VSKTDLHKFV EHLHGTMQTT QISK